Detailed information of TA system TA079178

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1291892..1292438
• Replicon: chromosome
• Accession: NZ_CP022527
• Organism: Neisseria sp. KEM232

Toxin (Protein)

• Gene name: relE
• Uniprot ID: L1NU40
• Locus tag: CGZ77_RS06425
• Protein ID: WP_009425682.1
• Coordinates: 1292124..1292438 (+)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: L1NTU0
• Locus tag: CGZ77_RS06420
• Protein ID: WP_009425683.1
• Coordinates: 1291892..1292134 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CGZ77_RS06405	1287352..1288098	+	747	WP_094031037.1	1-acyl-sn-glycerol-3-phosphate acyltransferase	-
CGZ77_RS06410	1288394..1290769	+	2376	WP_094031038.1	TonB-dependent hemoglobin/transferrin/lactoferrin family receptor	-
CGZ77_RS06415	1291113..1291730	+	618	WP_094031039.1	biliverdin-producing heme oxygenase	-
CGZ77_RS06420	1291892..1292134	+	243	WP_009425683.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CGZ77_RS06425	1292124..1292438	+	315	WP_009425682.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CGZ77_RS06430	1292513..1293352	-	840	WP_094031040.1	methylenetetrahydrofolate reductase [NAD(P)H]	-
CGZ77_RS12070	1293379..1293576	-	198	WP_009425680.1	hypothetical protein	-
CGZ77_RS06435	1293604..1294251	+	648	WP_094031041.1	adenylate kinase	-
CGZ77_RS06440	1294344..1294523	-	180	WP_094031042.1	hypothetical protein	-
CGZ77_RS06445	1294608..1295744	+	1137	WP_094031043.1	homoserine O-acetyltransferase	-
CGZ77_RS06450	1295741..1296325	+	585	WP_094031044.1	methionine biosynthesis protein MetW	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (17-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (7-74)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 12129.11 Da
• Isoelectric Point: 10.1480

>T79178 WP_009425682.1 NZ_CP022527:1292124-1292438 [Neisseria sp. KEM232]
MIYKVYKPEYKLAFCIEAKDEWNKLDDDVRQQLGKKLKKRLENLHAPSEALRNLSGFYKIKLRHAGCRLIYQMHGETLTV
VLVGIVGRQDRDAARKKAENRPDS

Nucleotide

• Length: 315 bp

>T79178 NZ_CP022527:1292124-1292438 [Neisseria sp. KEM232]
ATGATTTATAAAGTTTATAAGCCGGAATATAAACTGGCATTTTGCATTGAGGCGAAAGACGAATGGAACAAACTGGATGA
CGACGTCAGGCAGCAGTTGGGCAAGAAACTCAAAAAGCGTTTGGAAAACCTGCATGCGCCTTCGGAAGCCCTGCGTAATC
TGTCGGGCTTCTACAAAATCAAACTCCGCCACGCGGGATGCCGCCTTATTTATCAGATGCACGGCGAAACACTCACAGTT
GTCTTGGTCGGTATCGTCGGCAGGCAGGATAGGGACGCAGCCCGCAAGAAAGCGGAAAACAGGCCGGACAGTTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9204.48 Da
• Isoelectric Point: 4.3547

>AT79178 WP_009425683.1 NZ_CP022527:1291892-1292134 [Neisseria sp. KEM232]
MHTIFAEHAVSVTELKRNFSAIVQEAEGVVIVLNHNRPEAYLVPARFYEKLISYMEDFEDAKIVLERQDSPIIEVSIDDL

Nucleotide

• Length: 243 bp

>AT79178 NZ_CP022527:1291892-1292134 [Neisseria sp. KEM232]
ATGCACACTATATTTGCCGAACATGCCGTCAGCGTTACCGAACTCAAACGTAATTTCAGCGCGATCGTGCAGGAGGCCGA
AGGTGTCGTGATCGTACTCAACCACAACCGTCCGGAAGCCTATCTTGTCCCTGCCCGTTTTTACGAAAAGCTGATTTCTT
ATATGGAAGATTTCGAAGACGCCAAAATCGTGTTGGAGCGCCAGGATTCCCCGATCATAGAGGTATCTATCGATGATTTA
TAA

Structures

Toxin

• AlphaFold DB: L1NU40

Antitoxin

• AlphaFold DB: L1NTU0