79175

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 3913231..3913736 Replicon chromosome
Accession NZ_CP022526
Organism Pseudomonas aeruginosa strain Ocean-1155

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag CGU45_RS18695 Protein ID WP_003083773.1
Coordinates 3913231..3913512 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag CGU45_RS18700 Protein ID WP_003083775.1
Coordinates 3913509..3913736 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGU45_RS18670 3908482..3909831 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
CGU45_RS18675 3909880..3910566 + 687 WP_003083762.1 FadR family transcriptional regulator -
CGU45_RS18680 3910667..3911401 + 735 WP_003110658.1 GntR family transcriptional regulator -
CGU45_RS18685 3911605..3911991 + 387 WP_003083767.1 aegerolysin family protein -
CGU45_RS18690 3912023..3912931 - 909 WP_003083769.1 LysR family transcriptional regulator -
CGU45_RS18695 3913231..3913512 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
CGU45_RS18700 3913509..3913736 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
CGU45_RS18705 3913912..3914532 - 621 WP_003101226.1 hypothetical protein -
CGU45_RS18710 3914633..3915133 + 501 WP_003162763.1 LEA type 2 family protein -
CGU45_RS18715 3915206..3915547 + 342 WP_003101229.1 alkylphosphonate utilization protein -
CGU45_RS18720 3915630..3917057 - 1428 WP_003083784.1 GABA permease -
CGU45_RS18725 3917226..3918719 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T79175 WP_003083773.1 NZ_CP022526:c3913512-3913231 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T79175 NZ_CP022526:c3913512-3913231 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGTAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCCCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCTTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT79175 WP_003083775.1 NZ_CP022526:c3913736-3913509 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT79175 NZ_CP022526:c3913736-3913509 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCGTATCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References