Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 2054567..2055175 Replicon chromosome
Accession NZ_CP022526
Organism Pseudomonas aeruginosa strain Ocean-1155

Toxin (Protein)


Gene name PfiT Uniprot ID A0A509JBR4
Locus tag CGU45_RS09875 Protein ID WP_031638390.1
Coordinates 2054567..2054914 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag CGU45_RS09880 Protein ID WP_003114155.1
Coordinates 2054924..2055175 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGU45_RS09855 2050501..2050932 + 432 WP_019485901.1 phosphate-starvation-inducible PsiE family protein -
CGU45_RS09860 2050976..2051941 + 966 WP_003141083.1 M48 family metalloprotease -
CGU45_RS09865 2051966..2053117 + 1152 WP_012761372.1 trypsin-like peptidase domain-containing protein -
CGU45_RS09870 2053350..2054258 + 909 WP_003141085.1 LysR family transcriptional regulator -
CGU45_RS09875 2054567..2054914 - 348 WP_031638390.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CGU45_RS09880 2054924..2055175 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CGU45_RS09885 2055389..2056372 - 984 WP_034014422.1 tyrosine-type recombinase/integrase -
CGU45_RS09890 2056372..2057664 - 1293 WP_003123045.1 hypothetical protein -
CGU45_RS09895 2057923..2059185 - 1263 WP_033953311.1 hypothetical protein -
CGU45_RS09900 2059187..2059537 - 351 WP_003133726.1 DUF2523 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2035685..2068506 32821


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13018.79 Da        Isoelectric Point: 4.4212

>T79173 WP_031638390.1 NZ_CP022526:c2054914-2054567 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLVPFQGEQAAFQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEAAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

>T79173 NZ_CP022526:c2054914-2054567 [Pseudomonas aeruginosa]
ATGTCCCCGGTCGTCATTCGTTTTACTGATACCGCAGAGCAAAGCATCGAAGACCAAGTCCACCACTTGGTTCCATTCCA
AGGTGAACAGGCTGCATTCCAGTCAGTACTGAGCCTTTTGGATGAGATTGAAGAGAAGATTTCACTTGCACCTAAAGGTT
ACCCAGTCAGCCAGCAGGCGAGTCTTCTGGGGGTGCTGAGCTATCGCGAGCTTAATACCGGCCCCTATCGTGTTTTTTAC
GAATTCCACGAAGAGCAAGGCGAGGCGGCAGTGATCTTGGTTTTGCGACAGAAGCAGAGCGTTGAGCAGCAATTGATCCG
CTACTGCTTGGTGGGGCCAATCGAGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT79173 WP_003114155.1 NZ_CP022526:c2055175-2054924 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp

>AT79173 NZ_CP022526:c2055175-2054924 [Pseudomonas aeruginosa]
ATGCGAGTCGAGACAATTAGTTATTTGAAACGTCATGCGGCTGATCTGGATTTATCCGAGCCAATGGTCGTCACGCAGAA
CGGTGTTCCTGCCTATGTGGTTGAGTCATATGCTGAGCGGAAGCAGCGCGATGAAGCAATTGCGCTGGTGAAGTTGCTTG
CGATTGGCTCCCGCCAGTACGCAGAAGGCAAGCATCGCTCTGTTGATGATTTGAAAGCTCGCCTTTCCAGGAGGTTCGCT
CAGCCAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A509JBR4

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References