Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 1700853..1701358 Replicon chromosome
Accession NZ_CP022525
Organism Pseudomonas aeruginosa strain Ocean-1175

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag CGU46_RS08125 Protein ID WP_003083773.1
Coordinates 1701077..1701358 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag CGU46_RS08120 Protein ID WP_003083775.1
Coordinates 1700853..1701080 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGU46_RS08095 1695870..1697363 + 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
CGU46_RS08100 1697532..1698959 + 1428 WP_003083784.1 GABA permease -
CGU46_RS08105 1699042..1699383 - 342 WP_003101229.1 alkylphosphonate utilization protein -
CGU46_RS08110 1699456..1699956 - 501 WP_003162763.1 LEA type 2 family protein -
CGU46_RS08115 1700057..1700677 + 621 WP_003101226.1 hypothetical protein -
CGU46_RS08120 1700853..1701080 + 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
CGU46_RS08125 1701077..1701358 + 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
CGU46_RS08130 1701658..1702566 + 909 WP_003083769.1 LysR family transcriptional regulator -
CGU46_RS08135 1702598..1702984 - 387 WP_003083767.1 aegerolysin family protein -
CGU46_RS08140 1703188..1703922 - 735 WP_003110658.1 GntR family transcriptional regulator -
CGU46_RS08145 1704023..1704709 - 687 WP_003083762.1 FadR family transcriptional regulator -
CGU46_RS08150 1704758..1706107 - 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T79166 WP_003083773.1 NZ_CP022525:1701077-1701358 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T79166 NZ_CP022525:1701077-1701358 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGTAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCCCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCTTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT79166 WP_003083775.1 NZ_CP022525:1700853-1701080 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT79166 NZ_CP022525:1700853-1701080 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCGTATCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References