Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 5656169..5656785 Replicon chromosome
Accession NZ_CP022521
Organism Actinoalloteichus hoggarensis strain DSM 45943

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag AHOG_RS24075 Protein ID WP_093943359.1
Coordinates 5656169..5656579 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag AHOG_RS24080 Protein ID WP_093943360.1
Coordinates 5656576..5656785 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AHOG_RS24055 5651795..5653195 - 1401 WP_093943356.1 AAA family ATPase -
AHOG_RS24060 5653227..5654744 - 1518 WP_093943357.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA -
AHOG_RS24065 5654741..5655040 - 300 WP_093943358.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC -
AHOG_RS28910 5655111..5655308 - 198 WP_157737022.1 hypothetical protein -
AHOG_RS24070 5655403..5656056 + 654 WP_093944761.1 amino acid-binding protein -
AHOG_RS24075 5656169..5656579 - 411 WP_093943359.1 PIN domain nuclease Toxin
AHOG_RS24080 5656576..5656785 - 210 WP_093943360.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
AHOG_RS24085 5656860..5657405 - 546 WP_093943361.1 GNAT family N-acetyltransferase -
AHOG_RS24090 5657723..5659840 - 2118 Protein_4611 NAD-dependent DNA ligase LigA -
AHOG_RS24095 5660051..5661406 + 1356 WP_093943362.1 hemolysin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-41)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15271.54 Da        Isoelectric Point: 6.2361

>T79153 WP_093943359.1 NZ_CP022521:c5656579-5656169 [Actinoalloteichus hoggarensis]
MKAYLIDSSVWIDVLTDRPGAAQDRFVELAAEPDQIVTTEPVLMELRAGANGLRRLRIESVLNRLRLRGIDPAIDFHYAA
DLYRNVRISGHTVRSMVDCLIASVAVRTEAILVHRDRDFERIAAVASDLRSESLLT

Download         Length: 411 bp

>T79153 NZ_CP022521:c5656579-5656169 [Actinoalloteichus hoggarensis]
ATGAAGGCCTATCTGATCGACAGCTCGGTATGGATCGACGTCCTGACCGACCGTCCCGGTGCGGCCCAGGACAGGTTCGT
CGAACTGGCGGCGGAACCCGATCAGATCGTCACGACCGAACCGGTGCTCATGGAGCTGCGCGCCGGGGCGAACGGGCTGC
GGCGGCTGCGCATCGAATCGGTGCTCAACCGGCTGCGACTTCGTGGAATCGACCCGGCGATCGACTTTCACTACGCGGCG
GATCTGTATCGGAACGTGCGGATCTCCGGGCATACGGTGCGTTCGATGGTCGACTGCCTGATCGCCTCGGTGGCGGTGCG
CACCGAGGCGATCCTGGTGCACAGAGACCGTGATTTCGAACGGATCGCCGCGGTCGCCTCAGATCTTCGATCCGAGTCAC
TGCTGACCTGA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7787.76 Da        Isoelectric Point: 4.4550

>AT79153 WP_093943360.1 NZ_CP022521:c5656785-5656576 [Actinoalloteichus hoggarensis]
MSRTNIDLDDELVSEAMRRYDLTTKREAVDLALRRLVGPRVSTEELLALRGVGWDGDLDELRAGPPEHP

Download         Length: 210 bp

>AT79153 NZ_CP022521:c5656785-5656576 [Actinoalloteichus hoggarensis]
ATGAGTCGCACCAATATTGATCTCGACGACGAGCTGGTCAGCGAGGCGATGAGACGGTACGACCTCACCACGAAGCGTGA
AGCCGTGGACCTGGCATTGCGGCGGCTCGTGGGGCCGAGGGTCTCCACCGAGGAACTGCTCGCACTCCGAGGCGTCGGCT
GGGACGGCGACCTGGACGAGTTGCGCGCCGGGCCGCCCGAGCATCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References