Detailed information of TA system TA079149

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 1058841..1059382
• Replicon: chromosome
• Accession: NZ_CP022515
• Organism: Arenibacter algicola strain SMS7

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: AREALGSMS7_RS04575
• Protein ID: WP_093977416.1
• Coordinates: 1059080..1059382 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A221UT16
• Locus tag: AREALGSMS7_RS04570
• Protein ID: WP_031445645.1
• Coordinates: 1058841..1059083 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AREALGSMS7_RS04545	1054061..1054672	-	612	WP_093977413.1	dethiobiotin synthase	-
AREALGSMS7_RS04550	1054674..1055057	-	384	WP_031445641.1	DUF2007 domain-containing protein	-
AREALGSMS7_RS04555	1055054..1056211	-	1158	WP_093977414.1	8-amino-7-oxononanoate synthase	-
AREALGSMS7_RS04560	1056341..1058149	+	1809	WP_093980473.1	M61 family metallopeptidase	-
AREALGSMS7_RS04565	1058150..1058683	+	534	WP_093977415.1	GNAT family N-acetyltransferase	-
AREALGSMS7_RS04570	1058841..1059083	+	243	WP_031445645.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
AREALGSMS7_RS04575	1059080..1059382	+	303	WP_093977416.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AREALGSMS7_RS04580	1059716..1061356	+	1641	WP_198319202.1	hypothetical protein	-
AREALGSMS7_RS04585	1061582..1061791	+	210	WP_093977417.1	helix-turn-helix transcriptional regulator	-
AREALGSMS7_RS04590	1061788..1062123	+	336	WP_093977418.1	HipA N-terminal domain-containing protein	-
AREALGSMS7_RS04595	1062113..1063057	+	945	WP_093980475.1	HipA domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-94)

Antitoxin

• Antitoxin ParD (1-77)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 12144.01 Da
• Isoelectric Point: 10.1946

>T79149 WP_093977416.1 NZ_CP022515:1059080-1059382 [Arenibacter algicola]
MSNNRFRISKQATNDLNDIWIYTLRKWSKDQADRYYNLIIEEIEFVADNFMTGKSVEQTRKGYRVTKIKSHLIFYKKAED
DIVEIIRILHQRMDIKKRLS

Nucleotide

• Length: 303 bp

>T79149 NZ_CP022515:1059080-1059382 [Arenibacter algicola]
ATGAGTAACAACAGATTTCGAATCAGTAAACAAGCAACTAATGATTTAAATGACATTTGGATCTATACATTGCGAAAATG
GTCCAAAGACCAGGCAGATAGATACTATAATTTAATTATTGAAGAAATTGAGTTTGTTGCAGACAATTTTATGACTGGAA
AATCTGTGGAGCAGACTCGCAAGGGCTATCGGGTAACCAAAATAAAATCGCATCTAATTTTTTACAAAAAAGCTGAAGAC
GACATTGTAGAAATCATCAGAATTCTACATCAAAGAATGGATATTAAAAAGAGGCTGTCATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9334.41 Da
• Isoelectric Point: 5.9815

>AT79149 WP_031445645.1 NZ_CP022515:1058841-1059083 [Arenibacter algicola]
MSKNTSISLGNHFEEFVNDEVKSGRYSSVSEVIRSALRLLEHEEKKERELIKALEIGERSGFVDNFDPEQHLKDLHQRHL

Nucleotide

• Length: 243 bp

>AT79149 NZ_CP022515:1058841-1059083 [Arenibacter algicola]
ATGAGTAAAAACACATCAATATCACTCGGAAATCATTTTGAAGAATTTGTCAATGATGAAGTTAAATCTGGGAGATACAG
TTCTGTTAGTGAAGTAATACGCTCCGCATTAAGGTTATTGGAGCATGAAGAAAAAAAAGAAAGGGAATTGATTAAGGCTC
TCGAGATTGGAGAAAGAAGTGGGTTTGTGGACAACTTCGATCCTGAACAACATCTGAAAGACTTACATCAGCGACACTTA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A221UT16