Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 7699..8224 Replicon plasmid unnamed2
Accession NZ_CP022502
Organism Salmonella enterica subsp. enterica serovar Kentucky str. SA20030505

Toxin (Protein)


Gene name ccdB Uniprot ID F0JY91
Locus tag LFZ21_RS24185 Protein ID WP_001159869.1
Coordinates 7699..8004 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID H9TJP1
Locus tag LFZ21_RS24190 Protein ID WP_000813630.1
Coordinates 8006..8224 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LFZ21_RS24155 3180..3614 + 435 WP_000525034.1 IS200/IS605 family transposase -
LFZ21_RS24160 3826..5199 + 1374 WP_000244368.1 IS4 family transposase -
LFZ21_RS24165 5299..6348 - 1050 Protein_6 IS4 family transposase -
LFZ21_RS24170 6348..6485 - 138 Protein_7 Lrp/AsnC family transcriptional regulator -
LFZ21_RS24175 6602..7513 + 912 WP_000549737.1 DMT family transporter -
LFZ21_RS24180 7498..7698 - 201 Protein_9 phage integrase family protein -
LFZ21_RS24185 7699..8004 - 306 WP_001159869.1 type II toxin-antitoxin system toxin CcdB Toxin
LFZ21_RS24190 8006..8224 - 219 WP_000813630.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
LFZ21_RS24205 9283..9738 + 456 WP_024133208.1 hypothetical protein -
LFZ21_RS24210 9801..10397 + 597 Protein_13 IS66 family transposase -
LFZ21_RS24220 10633..11052 - 420 WP_094890042.1 transposase -
LFZ21_RS24245 12202..12535 + 334 Protein_15 IS66 family insertion sequence element accessory protein TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..66760 66760


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 15030.03 Da        Isoelectric Point: 5.5500

>T79147 WP_001159869.1 NZ_CP022502:c8004-7699 [Salmonella enterica subsp. enterica serovar Kentucky str.]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Download         Length: 306 bp

>T79147 NZ_CP022502:c8004-7699 [Salmonella enterica subsp. enterica serovar Kentucky str.]
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TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 10761.91 Da        Isoelectric Point: 5.5500

>AT79147 WP_000813630.1 NZ_CP022502:c8224-8006 [Salmonella enterica subsp. enterica serovar Kentucky str.]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 219 bp

>AT79147 NZ_CP022502:c8224-8006 [Salmonella enterica subsp. enterica serovar Kentucky str.]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
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Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2SIB9

Antitoxin

Source ID Structure
AlphaFold DB A0A829CEF5

References