79142

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2620865..2621436 Replicon chromosome
Accession NZ_CP022488
Organism Enterococcus faecalis ARO1/DG

Toxin (Protein)


Gene name mazF Uniprot ID R3GRA7
Locus tag CG806_RS14220 Protein ID WP_002360937.1
Coordinates 2620865..2621206 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID S4CGQ1
Locus tag CG806_RS14225 Protein ID WP_002367500.1
Coordinates 2621206..2621436 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CG806_RS14210 2616729..2620343 - 3615 WP_010712913.1 DNA-directed RNA polymerase subunit beta -
CG806_RS14220 2620865..2621206 - 342 WP_002360937.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
CG806_RS14225 2621206..2621436 - 231 WP_002367500.1 hypothetical protein Antitoxin
CG806_RS14230 2621843..2622058 - 216 WP_002358974.1 zinc ribbon domain-containing protein -
CG806_RS14235 2622197..2623189 + 993 WP_002367501.1 biotin--[acetyl-CoA-carboxylase] ligase -
CG806_RS14240 2623453..2624091 - 639 WP_002378863.1 lytic polysaccharide monooxygenase -
CG806_RS14250 2624777..2626393 + 1617 WP_002372620.1 phosphatase PAP2/LCP family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13165.41 Da        Isoelectric Point: 9.3988

>T79142 WP_002360937.1 NZ_CP022488:c2621206-2620865 [Enterococcus faecalis ARO1/DG]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETHGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

>T79142 NZ_CP022488:c2621206-2620865 [Enterococcus faecalis ARO1/DG]
ATGAACGTTGAAAAGAAGTACATTCCCAAAAAAGGAGATATTGTATGGATTGATTTTGATCCTGCTGCAGGTAAAGAAAT
TCAGAAGAGACGCCCTGGTTTAGTCGTGTCAAGATATGAATTTAATCGGAAAACCATGTTTGCTGTGATTTGCCCGATTA
CTTCCACCATTAAAAATATTCCCACTCGATATACGTTGCCCGATGACATAGAAACCCATGGGCAAGTAGTGATCTCACAA
CTGAAATCTTTGGACTTCACTGAAAGAAAATTAAGTCAAATTGAGCATTTGCCATTAAAAGATATGGCGAAAATTGACCA
AATAATTGAATATATTTTCTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8704.69 Da        Isoelectric Point: 4.3313

>AT79142 WP_002367500.1 NZ_CP022488:c2621436-2621206 [Enterococcus faecalis ARO1/DG]
MLTTKSRRQGNSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp

>AT79142 NZ_CP022488:c2621436-2621206 [Enterococcus faecalis ARO1/DG]
ATGCTAACAACTAAATCAAGAAGACAAGGAAACTCGGTCGTTTTAACTTTACCCACTGATAATGGTAAAAAACCAAAAGT
CGACCAAGAATATATTGTGATGTATTCTGACGACGGTACAATTACATTAGTCCCTAAAATTCAGGATCCATTTAGTGAAG
GTCCAGAAGGTGAGTATTATGAAAAAGATGAGTGGCATGATCTTGCACCTGAGGGGAGAGAACTTTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2A7G9

Antitoxin

Source ID Structure
AlphaFold DB S4CGQ1

References