79116

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) toxT-higA/Tad-HTH_37
Location 522942..523579 Replicon chromosome
Accession NZ_CP022479
Organism Faecalibacterium prausnitzii strain A2165

Toxin (Protein)


Gene name toxT Uniprot ID -
Locus tag CG447_RS02660 Protein ID WP_099357206.1
Coordinates 523220..523579 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CG447_RS02655 Protein ID WP_035394514.1
Coordinates 522942..523223 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CG447_RS02630 518540..519691 - 1152 WP_099357205.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -
CG447_RS02635 519708..520568 - 861 WP_005933875.1 phosphatidate cytidylyltransferase -
CG447_RS02640 520599..521312 - 714 WP_035394393.1 di-trans,poly-cis-decaprenylcistransferase -
CG447_RS02645 521425..521979 - 555 WP_005933879.1 ribosome recycling factor -
CG447_RS02650 522067..522777 - 711 WP_005933880.1 UMP kinase -
CG447_RS02655 522942..523223 - 282 WP_035394514.1 helix-turn-helix domain-containing protein Antitoxin
CG447_RS02660 523220..523579 - 360 WP_099357206.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CG447_RS02670 523833..524174 - 342 WP_005933882.1 hypothetical protein -
CG447_RS02675 524321..524719 - 399 WP_005933883.1 hypothetical protein -
CG447_RS02680 524748..526043 - 1296 WP_035394396.1 diaminopimelate decarboxylase -
CG447_RS02685 526218..528071 - 1854 WP_035394516.1 polysaccharide biosynthesis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(20-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-82)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13724.79 Da        Isoelectric Point: 9.2962

>T79116 WP_099357206.1 NZ_CP022479:c523579-523220 [Faecalibacterium prausnitzii]
VQEYEIEFYDKADGSEPAKEFILALDAKMRAKVVRTVGLLREEGPSLREPYSKHLEDGIFEIRTKFGSDITRVLYFFVIG
RRIILTNGFVKKTQKTPASEIALAKQYRADYLSRKECSQ

Download         Length: 360 bp

>T79116 NZ_CP022479:c523579-523220 [Faecalibacterium prausnitzii]
GTGCAGGAATACGAGATCGAATTTTATGACAAAGCCGATGGCTCCGAACCGGCGAAAGAGTTTATTCTGGCTCTGGATGC
GAAAATGCGGGCCAAGGTCGTGCGCACGGTCGGGCTTCTCCGGGAGGAAGGGCCTTCACTGCGGGAGCCGTACTCCAAGC
ATCTGGAGGATGGCATTTTTGAGATCCGCACCAAGTTCGGCTCCGACATTACCCGTGTGCTGTACTTTTTTGTGATCGGC
AGAAGGATCATCCTTACGAACGGCTTTGTCAAAAAGACGCAGAAGACACCTGCTTCCGAGATCGCACTTGCAAAGCAGTA
CCGTGCCGATTATCTCAGCCGAAAGGAGTGCTCGCAATGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10424.87 Da        Isoelectric Point: 4.8279

>AT79116 WP_035394514.1 NZ_CP022479:c523223-522942 [Faecalibacterium prausnitzii]
MTNFNDFLNEQMKDPEFKAEWDALDPEFAVIEAILAARKESGLTQQQLSERTGIAQTDISKLERGNGNPSLRTLQRLAAG
MGMRVKIEFVPAK

Download         Length: 282 bp

>AT79116 NZ_CP022479:c523223-522942 [Faecalibacterium prausnitzii]
ATGACCAATTTCAATGATTTTCTCAACGAACAGATGAAAGATCCTGAGTTTAAGGCAGAGTGGGATGCCCTTGACCCCGA
ATTTGCTGTGATCGAGGCGATCCTTGCCGCCCGGAAGGAAAGCGGACTGACCCAGCAGCAGCTTTCCGAGCGCACCGGCA
TTGCCCAGACAGACATCAGCAAGCTGGAGCGCGGCAACGGAAATCCTTCGCTTCGCACCCTGCAGCGGCTGGCTGCCGGT
ATGGGGATGCGGGTCAAGATCGAATTTGTTCCGGCAAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References