Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) toxT-higA/Tad-HTH_37
Location 522942..523579 Replicon chromosome
Accession NZ_CP022479
Organism Faecalibacterium prausnitzii strain A2165

Toxin (Protein)


Gene name toxT Uniprot ID -
Locus tag CG447_RS02660 Protein ID WP_099357206.1
Coordinates 523220..523579 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CG447_RS02655 Protein ID WP_035394514.1
Coordinates 522942..523223 (-) Length 94 a.a.

Genomic Context

CG447_RS02630CG447_RS02635CG447_RS02640CG447_RS02645CG447_RS02650CG447_RS02655CG447_RS02660CG447_RS02670CG447_RS02675CG447_RS02680CG447_RS02685
Location: 518540..519691 (1152 bp)
Type: Others
Protein ID: WP_099357205.1
Location: 519708..520568 (861 bp)
Type: Others
Protein ID: WP_005933875.1
Location: 520599..521312 (714 bp)
Type: Others
Protein ID: WP_035394393.1
Location: 521425..521979 (555 bp)
Type: Others
Protein ID: WP_005933879.1
Location: 522067..522777 (711 bp)
Type: Others
Protein ID: WP_005933880.1
Location: 522942..523223 (282 bp)
Type: Antitoxin
Protein ID: WP_035394514.1
Location: 523220..523579 (360 bp)
Type: Toxin
Protein ID: WP_099357206.1
Location: 523833..524174 (342 bp)
Type: Others
Protein ID: WP_005933882.1
Location: 524321..524719 (399 bp)
Type: Others
Protein ID: WP_005933883.1
Location: 524748..526043 (1296 bp)
Type: Others
Protein ID: WP_035394396.1
Location: 526218..528071 (1854 bp)
Type: Others
Protein ID: WP_035394516.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CG447_RS02630518540..519691-1152WP_099357205.11-deoxy-D-xylulose-5-phosphate reductoisomerase-
CG447_RS02635519708..520568-861WP_005933875.1phosphatidate cytidylyltransferase-
CG447_RS02640520599..521312-714WP_035394393.1di-trans,poly-cis-decaprenylcistransferase-
CG447_RS02645521425..521979-555WP_005933879.1ribosome recycling factor-
CG447_RS02650522067..522777-711WP_005933880.1UMP kinase-
CG447_RS02655522942..523223-282WP_035394514.1helix-turn-helix domain-containing proteinAntitoxin
CG447_RS02660523220..523579-360WP_099357206.1type II toxin-antitoxin system RelE/ParE family toxinToxin
CG447_RS02670523833..524174-342WP_005933882.1hypothetical protein-
CG447_RS02675524321..524719-399WP_005933883.1hypothetical protein-
CG447_RS02680524748..526043-1296WP_035394396.1diaminopimelate decarboxylase-
CG447_RS02685526218..528071-1854WP_035394516.1polysaccharide biosynthesis protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(20-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-82)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13724.79 Da        Isoelectric Point: 9.2962

>T79116 WP_099357206.1 NZ_CP022479:c523579-523220 [Faecalibacterium prausnitzii]
VQEYEIEFYDKADGSEPAKEFILALDAKMRAKVVRTVGLLREEGPSLREPYSKHLEDGIFEIRTKFGSDITRVLYFFVIG
RRIILTNGFVKKTQKTPASEIALAKQYRADYLSRKECSQ

Download         Length: 360 bp

>T79116 NZ_CP022479:c523579-523220 [Faecalibacterium prausnitzii]
GTGCAGGAATACGAGATCGAATTTTATGACAAAGCCGATGGCTCCGAACCGGCGAAAGAGTTTATTCTGGCTCTGGATGC
GAAAATGCGGGCCAAGGTCGTGCGCACGGTCGGGCTTCTCCGGGAGGAAGGGCCTTCACTGCGGGAGCCGTACTCCAAGC
ATCTGGAGGATGGCATTTTTGAGATCCGCACCAAGTTCGGCTCCGACATTACCCGTGTGCTGTACTTTTTTGTGATCGGC
AGAAGGATCATCCTTACGAACGGCTTTGTCAAAAAGACGCAGAAGACACCTGCTTCCGAGATCGCACTTGCAAAGCAGTA
CCGTGCCGATTATCTCAGCCGAAAGGAGTGCTCGCAATGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10424.87 Da        Isoelectric Point: 4.8279

>AT79116 WP_035394514.1 NZ_CP022479:c523223-522942 [Faecalibacterium prausnitzii]
MTNFNDFLNEQMKDPEFKAEWDALDPEFAVIEAILAARKESGLTQQQLSERTGIAQTDISKLERGNGNPSLRTLQRLAAG
MGMRVKIEFVPAK

Download         Length: 282 bp

>AT79116 NZ_CP022479:c523223-522942 [Faecalibacterium prausnitzii]
ATGACCAATTTCAATGATTTTCTCAACGAACAGATGAAAGATCCTGAGTTTAAGGCAGAGTGGGATGCCCTTGACCCCGA
ATTTGCTGTGATCGAGGCGATCCTTGCCGCCCGGAAGGAAAGCGGACTGACCCAGCAGCAGCTTTCCGAGCGCACCGGCA
TTGCCCAGACAGACATCAGCAAGCTGGAGCGCGGCAACGGAAATCCTTCGCTTCGCACCCTGCAGCGGCTGGCTGCCGGT
ATGGGGATGCGGGTCAAGATCGAATTTGTTCCGGCAAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References