Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 88493..89058 Replicon chromosome
Accession NZ_CP022479
Organism Faecalibacterium prausnitzii strain A2165

Toxin (Protein)


Gene name relE Uniprot ID C7H6P5
Locus tag CG447_RS00505 Protein ID WP_002596328.1
Coordinates 88493..88783 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID C7H6P4
Locus tag CG447_RS00510 Protein ID WP_005924829.1
Coordinates 88780..89058 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CG447_RS00480 84993..85406 + 414 WP_035394329.1 hypothetical protein -
CG447_RS00485 85510..85962 + 453 WP_005933558.1 hypothetical protein -
CG447_RS00490 85973..86434 + 462 WP_035394327.1 sigma-70 family RNA polymerase sigma factor -
CG447_RS00495 86463..86753 + 291 WP_005933556.1 DUF3847 domain-containing protein -
CG447_RS00500 86940..88385 + 1446 WP_007037415.1 MobA/MobL family protein -
CG447_RS00505 88493..88783 - 291 WP_002596328.1 type II toxin-antitoxin system YafQ family toxin Toxin
CG447_RS00510 88780..89058 - 279 WP_005924829.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CG447_RS00515 89185..89583 + 399 WP_005933550.1 cysteine-rich VLP domain-containing protein -
CG447_RS00520 89697..90446 + 750 WP_005933547.1 phage replisome organizer N-terminal domain-containing protein -
CG447_RS00525 90443..91306 + 864 WP_005933545.1 ATP-binding protein -
CG447_RS00530 91350..91544 + 195 WP_005933543.1 transposon-encoded TnpW family protein -
CG447_RS00535 91622..91987 + 366 WP_014080225.1 hypothetical protein -
CG447_RS00540 92095..92409 - 315 WP_050762801.1 hypothetical protein -
CG447_RS00545 92449..92895 - 447 WP_005933531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 76181..92424 16243


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-94)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-90)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11112.87 Da        Isoelectric Point: 8.0630

>T79115 WP_002596328.1 NZ_CP022479:c88783-88493 [Faecalibacterium prausnitzii]
MKETKYTVKYTTSFKKDYKRAIKRGLKIELLEQVVALLAMGEPLPDKNRDHDLSGDWAGHRECHILPDWLLVYRIEDDVL
VLTLARTGTHSDLFGK

Download         Length: 291 bp

>T79115 NZ_CP022479:c88783-88493 [Faecalibacterium prausnitzii]
ATGAAAGAAACCAAATATACCGTCAAGTACACGACCAGTTTCAAAAAGGACTACAAACGAGCCATCAAGCGTGGCTTGAA
GATTGAGCTGCTGGAGCAGGTCGTAGCATTGCTGGCAATGGGCGAACCGCTGCCGGATAAGAACCGTGACCATGACCTGT
CCGGCGATTGGGCAGGTCATCGGGAATGTCATATTCTCCCGGACTGGCTGCTTGTCTATCGCATAGAGGATGATGTTCTG
GTGCTGACGCTGGCCCGCACCGGCACACACAGCGACTTGTTCGGCAAATAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10247.66 Da        Isoelectric Point: 4.4692

>AT79115 WP_005924829.1 NZ_CP022479:c89058-88780 [Faecalibacterium prausnitzii]
MAGNTTNISIRMDADLKAQADALFTELGMNLTTAFNIFVRQSLREGGIPFEVRLEQPNKETVAAMLEAERIAKDPSVKGY
NDLDELFADLKR

Download         Length: 279 bp

>AT79115 NZ_CP022479:c89058-88780 [Faecalibacterium prausnitzii]
ATGGCTGGAAATACCACAAACATCAGTATCCGCATGGACGCAGATTTGAAAGCGCAGGCGGACGCACTGTTTACGGAACT
TGGCATGAACCTGACTACGGCGTTTAACATCTTTGTGCGCCAGTCGCTTCGTGAAGGCGGCATTCCCTTTGAAGTAAGGC
TGGAACAGCCGAACAAAGAAACGGTTGCTGCCATGCTGGAAGCGGAAAGGATTGCAAAAGACCCGTCTGTAAAGGGCTAC
AATGACCTTGACGAGTTATTTGCTGACCTGAAAAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M4XBM1

Antitoxin

Source ID Structure
AlphaFold DB A0A1M4XB19

References