79114

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 5663433..5663938 Replicon chromosome
Accession NZ_CP022478
Organism Pseudomonas aeruginosa strain LW

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag CEK59_RS26840 Protein ID WP_003083773.1
Coordinates 5663433..5663714 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag CEK59_RS26845 Protein ID WP_003083775.1
Coordinates 5663711..5663938 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEK59_RS26815 5658687..5660036 + 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -
CEK59_RS26820 5660085..5660771 + 687 WP_003083762.1 FadR family transcriptional regulator -
CEK59_RS26825 5660872..5661606 + 735 WP_003128333.1 GntR family transcriptional regulator -
CEK59_RS26830 5661810..5662196 + 387 WP_003083767.1 aegerolysin family protein -
CEK59_RS26835 5662228..5663136 - 909 WP_003083769.1 LysR family transcriptional regulator -
CEK59_RS26840 5663433..5663714 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
CEK59_RS26845 5663711..5663938 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
CEK59_RS26850 5664114..5664734 - 621 WP_003101226.1 hypothetical protein -
CEK59_RS26855 5664835..5665335 + 501 WP_003083778.1 LEA type 2 family protein -
CEK59_RS26860 5665408..5665749 + 342 WP_014603467.1 alkylphosphonate utilization protein -
CEK59_RS26865 5665831..5667258 - 1428 WP_003083784.1 GABA permease -
CEK59_RS26870 5667427..5668920 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T79114 WP_003083773.1 NZ_CP022478:c5663714-5663433 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T79114 NZ_CP022478:c5663714-5663433 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCCCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCTTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT79114 WP_003083775.1 NZ_CP022478:c5663938-5663711 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT79114 NZ_CP022478:c5663938-5663711 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCGTATCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References