Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3725722..3726358 Replicon chromosome
Accession NZ_CP022477
Organism Bacillus licheniformis strain BL-010

Toxin (Protein)


Gene name mazF Uniprot ID M5P3Q9
Locus tag CG450_RS19655 Protein ID WP_003179128.1
Coordinates 3725722..3726072 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID M5PDU2
Locus tag CG450_RS19660 Protein ID WP_006638778.1
Coordinates 3726077..3726358 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CG450_RS19615 3720763..3721362 - 600 WP_003179145.1 SpoIIE family protein phosphatase -
CG450_RS19620 3721359..3722150 - 792 WP_003179144.1 RNA polymerase sigma factor SigB -
CG450_RS19625 3722116..3722601 - 486 WP_003179142.1 anti-sigma B factor RsbW -
CG450_RS19630 3722601..3722927 - 327 WP_003179140.1 anti-sigma factor antagonist -
CG450_RS19635 3722986..3723993 - 1008 WP_003179137.1 PP2C family protein-serine/threonine phosphatase -
CG450_RS19640 3724004..3724405 - 402 WP_003179135.1 anti-sigma regulatory factor -
CG450_RS19645 3724408..3724773 - 366 WP_003179132.1 STAS domain-containing protein -
CG450_RS19650 3724777..3725604 - 828 WP_003179130.1 RsbT co-antagonist protein RsbRA -
CG450_RS19655 3725722..3726072 - 351 WP_003179128.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
CG450_RS19660 3726077..3726358 - 282 WP_006638778.1 hypothetical protein Antitoxin
CG450_RS19665 3726470..3727639 - 1170 WP_026080763.1 alanine racemase -
CG450_RS19670 3727864..3728823 - 960 WP_152847888.1 outer membrane lipoprotein carrier protein LolA -
CG450_RS19675 3729166..3729765 + 600 WP_003179118.1 rhomboid family intramembrane serine protease -
CG450_RS19680 3729762..3731243 - 1482 WP_009330132.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12990.03 Da        Isoelectric Point: 5.7234

>T79108 WP_003179128.1 NZ_CP022477:c3726072-3725722 [Bacillus licheniformis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNNIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVNEALQISLALIDF

Download         Length: 351 bp

>T79108 NZ_CP022477:c3726072-3725722 [Bacillus licheniformis]
TTGATTGTTAAACGCGGCGATGTTTATTTTGCTGACCTATCTCCTGTTGTTGGCTCAGAACAAGGCGGGGTGCGCCCGGT
TTTAGTGATTCAAAACAACATCGGCAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CAAAATTACCTACCCACGTCGAAATTGATGCGAAACGCTACGGTTTTGAAAGAGACTCCGTTATATTGCTCGAACAAATT
CGGACGATTGACAAGCAAAGATTAACGGACAAAATCACCCATCTCGATGATGAAATGATGGAAAAGGTCAACGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10649.03 Da        Isoelectric Point: 4.6920

>AT79108 WP_006638778.1 NZ_CP022477:c3726358-3726077 [Bacillus licheniformis]
MSESSATTEILIRLPEALVSELDGVVMQDNGSRNELIYQATKMYLRERKNRQIRESMRRGYMEMAKINLNISSEAQFAEY
EAENTVERLVSGG

Download         Length: 282 bp

>AT79108 NZ_CP022477:c3726358-3726077 [Bacillus licheniformis]
TTGTCTGAATCCAGCGCAACAACTGAAATATTGATTCGCTTGCCAGAAGCTTTAGTATCAGAACTGGATGGTGTCGTCAT
GCAAGATAACGGGAGCAGAAATGAACTGATTTACCAAGCCACAAAAATGTATTTACGCGAACGCAAAAATCGACAAATTC
GGGAATCGATGAGACGCGGTTATATGGAGATGGCCAAGATCAATTTGAACATCTCTTCTGAGGCTCAATTTGCAGAGTAT
GAGGCTGAAAACACAGTAGAGCGCTTAGTAAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I7FHI4

Antitoxin

Source ID Structure
AlphaFold DB M5PDU2

References