Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PhRel2-ATphRel2/DUF4065(antitoxin)
Location 1066705..1068167 Replicon chromosome
Accession NZ_CP022477
Organism Bacillus licheniformis strain BL-010

Toxin (Protein)


Gene name phRel2 Uniprot ID -
Locus tag CG450_RS05410 Protein ID WP_017474550.1
Coordinates 1066705..1067415 (+) Length 237 a.a.

Antitoxin (Protein)


Gene name ATphRel2 Uniprot ID -
Locus tag CG450_RS05415 Protein ID WP_017474549.1
Coordinates 1067418..1068167 (+) Length 250 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CG450_RS05370 1061801..1061983 + 183 WP_017474916.1 XkdX family protein -
CG450_RS05375 1062084..1062917 + 834 WP_017474917.1 hypothetical protein -
CG450_RS05380 1063000..1063269 + 270 WP_017474918.1 hemolysin XhlA family protein -
CG450_RS05385 1063285..1063548 + 264 WP_017474919.1 phage holin -
CG450_RS05390 1063600..1064679 + 1080 WP_075218312.1 N-acetylmuramoyl-L-alanine amidase -
CG450_RS22490 1064687..1064833 + 147 WP_017474554.1 hypothetical protein -
CG450_RS05395 1065099..1065272 - 174 WP_017474553.1 hypothetical protein -
CG450_RS05400 1065320..1066129 - 810 WP_017474552.1 ATP-dependent DNA ligase -
CG450_RS05405 1066255..1066344 + 90 Protein_1066 peptidoglycan-binding protein -
CG450_RS22495 1066350..1066433 + 84 Protein_1067 LysM peptidoglycan-binding domain-containing protein -
CG450_RS05410 1066705..1067415 + 711 WP_017474550.1 hypothetical protein Toxin
CG450_RS05415 1067418..1068167 + 750 WP_017474549.1 DUF4065 domain-containing protein Antitoxin
CG450_RS05420 1068535..1069716 - 1182 WP_016886467.1 oxalate decarboxylase family bicupin -
CG450_RS05425 1070031..1071212 + 1182 WP_003184708.1 alanine racemase -
CG450_RS05430 1071387..1072304 + 918 WP_003184707.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1016865..1068167 51302


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(113-224)


Sequences

Toxin        


Download         Length: 237 a.a.        Molecular weight: 28189.80 Da        Isoelectric Point: 6.8925

>T79106 WP_017474550.1 NZ_CP022477:1066705-1067415 [Bacillus licheniformis]
VINCTCEVESFCYSFYNLIVEINEAHSEFSKEFASEKQDALINLKRKQVNHVTQVKNGNTFSVDNLFLQLISNYREKLLD
YIATDVDFESQYTDLILRARTKESTSIINKLKYYLVGKNEAGKLPLNKCLNDLFGFRIHPTFFDHNKECFQETCQRLKQL
YKNRIDFRDSSKGNYKAYHIYLYGESWEYFPWEIQVWRLSDREQNDLSHKQHKQEHRKWAAIYKNSTEIELEMEGV

Download         Length: 711 bp

>T79106 NZ_CP022477:1066705-1067415 [Bacillus licheniformis]
GTGATTAATTGTACGTGTGAAGTAGAGTCATTTTGTTATAGTTTTTATAACTTAATAGTTGAAATTAATGAAGCGCATAG
TGAATTTTCAAAAGAGTTCGCTTCTGAAAAACAAGATGCTCTAATTAACTTAAAAAGAAAACAAGTTAATCATGTTACTC
AAGTAAAAAATGGGAACACTTTTTCTGTTGATAATTTGTTTTTGCAGTTGATTTCAAATTATCGAGAGAAGTTGCTTGAT
TATATTGCAACTGATGTTGATTTTGAAAGTCAATATACGGATTTAATTCTAAGGGCAAGAACTAAGGAATCCACTTCAAT
CATTAATAAGCTTAAATATTATCTTGTTGGAAAAAATGAAGCAGGAAAACTACCTCTTAACAAATGCTTGAATGATTTAT
TTGGATTTAGAATACATCCAACATTTTTTGACCATAATAAGGAATGTTTTCAAGAGACATGTCAAAGGTTAAAGCAACTA
TATAAAAATCGAATTGATTTTAGGGATTCATCAAAGGGAAATTATAAAGCGTATCATATTTATTTATACGGAGAGAGTTG
GGAATACTTCCCTTGGGAAATACAAGTATGGCGCTTAAGTGATCGTGAACAGAATGATTTATCGCATAAGCAGCATAAAC
AAGAACATAGGAAATGGGCTGCAATTTACAAAAATTCAACAGAAATAGAATTAGAAATGGAAGGTGTTTAG

Antitoxin


Download         Length: 250 a.a.        Molecular weight: 29056.07 Da        Isoelectric Point: 6.4106

>AT79106 WP_017474549.1 NZ_CP022477:1067418-1068167 [Bacillus licheniformis]
MAFHFIAIVSDFSGGRRYGWHYSSEDRLDKDYIKSFMTKVKQKCGHIQFGIHKLTTEDTSWASVVRMDSFFDDVIITNRI
DDFIDVVANDQQLSAYDVAKFVLATLPTSHLKLQKLLYYIYSEFLVRTGEKLFKDRIVAYKYGPVVEDVFHKYRKHGSSE
IDYKEDATFVLRTDEQAFTPSLMKIWTSEYGVAALECIIETLEKYGDLDAFRLVDKTHQKGGPWERVYKPGQNCEITDEL
ITLYHKYVQ

Download         Length: 750 bp

>AT79106 NZ_CP022477:1067418-1068167 [Bacillus licheniformis]
ATGGCTTTTCATTTTATTGCAATCGTAAGTGACTTCTCTGGTGGGAGAAGATACGGTTGGCATTATTCAAGTGAAGACAG
GTTAGATAAAGATTATATTAAGTCTTTTATGACCAAAGTTAAACAAAAATGTGGACATATTCAATTTGGAATTCATAAAC
TAACTACTGAGGATACATCTTGGGCTTCAGTAGTAAGAATGGATTCGTTCTTTGATGATGTTATAATAACAAATCGAATT
GACGACTTTATAGATGTTGTTGCAAATGATCAACAGCTTTCCGCTTATGATGTTGCTAAATTCGTACTAGCTACGCTCCC
TACATCACATTTGAAATTGCAAAAGTTGCTATACTATATCTACTCTGAATTTCTGGTCAGAACTGGGGAAAAATTATTCA
AAGATCGGATAGTTGCTTATAAGTATGGACCTGTAGTAGAAGATGTTTTTCATAAGTATCGAAAACATGGTAGCTCGGAA
ATTGATTATAAAGAGGATGCGACTTTCGTGTTGCGAACAGATGAACAAGCATTTACACCCTCTTTAATGAAAATTTGGAC
TTCTGAATATGGAGTAGCAGCGTTAGAATGTATTATAGAAACATTGGAGAAATATGGTGATCTAGATGCATTCAGGTTAG
TTGACAAAACTCATCAAAAAGGGGGGCCATGGGAAAGAGTTTATAAACCTGGTCAAAATTGTGAAATCACTGATGAGTTA
ATAACTCTATATCATAAATATGTACAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References