Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1372315..1372874 Replicon chromosome
Accession NZ_CP022473
Organism Vibrio parahaemolyticus strain MAVP-Q

Toxin (Protein)


Gene name relE Uniprot ID A0A347UR22
Locus tag BGM07_RS15710 Protein ID WP_005398411.1
Coordinates 1372315..1372593 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR21
Locus tag BGM07_RS15715 Protein ID WP_005398409.1
Coordinates 1372590..1372874 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BGM07_RS15655 1367377..1367874 + 498 WP_021448757.1 DNA topology modulation protein -
BGM07_RS15660 1367903..1367981 + 79 Protein_1222 DUF3265 domain-containing protein -
BGM07_RS15665 1368356..1368445 + 90 WP_079765069.1 DUF3265 domain-containing protein -
BGM07_RS15670 1368473..1368931 + 459 WP_025613401.1 hypothetical protein -
BGM07_RS15675 1368959..1369051 + 93 WP_079765067.1 DUF3265 domain-containing protein -
BGM07_RS15680 1369506..1369598 + 93 WP_193386937.1 DUF3265 domain-containing protein -
BGM07_RS15690 1370110..1370652 + 543 WP_079765068.1 hypothetical protein -
BGM07_RS15700 1370803..1371681 + 879 WP_021448752.1 hypothetical protein -
BGM07_RS15705 1371820..1372179 + 360 WP_021448750.1 DUF2750 domain-containing protein -
BGM07_RS15710 1372315..1372593 - 279 WP_005398411.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
BGM07_RS15715 1372590..1372874 - 285 WP_005398409.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BGM07_RS15725 1373063..1373401 + 339 WP_021448749.1 hypothetical protein -
BGM07_RS15730 1373930..1374052 + 123 WP_108702465.1 DUF3265 domain-containing protein -
BGM07_RS15735 1374082..1374543 + 462 WP_021448746.1 DUF1851 domain-containing protein -
BGM07_RS15740 1375308..1375865 + 558 WP_021448745.1 hypothetical protein -
BGM07_RS26605 1375957..1376130 + 174 WP_021448744.1 hypothetical protein -
BGM07_RS15745 1376343..1376756 + 414 WP_021448743.1 hypothetical protein -
BGM07_RS15750 1377399..1377716 + 318 WP_021448742.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 1307049..1428121 121072


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10891.57 Da        Isoelectric Point: 4.3430

>T79105 WP_005398411.1 NZ_CP022473:c1372593-1372315 [Vibrio parahaemolyticus]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPTD

Download         Length: 279 bp

>T79105 NZ_CP022473:c1372593-1372315 [Vibrio parahaemolyticus]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAAATCTTCGAGTTTCTCTATGACTTCAACCCTGATGCGGC
AGAGAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGTGTACAACGAGATGGCA
TCCGCGGACGATTGCTCATTATTCCTGAGATTTCGATGATTGTCTCTTACTGGGTCGAGGGCGATATCATCCGAGTTATG
CGTGTACTCCACCAGAAACAAAAATTCCCTACGGATTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11069.40 Da        Isoelectric Point: 9.2167

>AT79105 WP_005398409.1 NZ_CP022473:c1372874-1372590 [Vibrio parahaemolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ

Download         Length: 285 bp

>AT79105 NZ_CP022473:c1372874-1372590 [Vibrio parahaemolyticus]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGCAC
TCTGAGTGACGCATGCCGTGAACTTACTGAGCAACTTGCTGAACAACAAAGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAGTCCGTTTTCGTTGAGCACCAAACTGCTAAATCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGCAATCGAGGTAAGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR22

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR21

References