Detailed information of TA system TA079104

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 1033163..1033710
• Replicon: chromosome
• Accession: NZ_CP022469
• Organism: Vibrio anguillarum strain MHK3

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A347UR19
• Locus tag: CG015_RS18520
• Protein ID: WP_025548916.1
• Coordinates: 1033163..1033465 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: CG015_RS18525
• Protein ID: WP_129533177.1
• Coordinates: 1033453..1033710 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CG015_RS19025	1028296..1028430	-	135	WP_164996854.1	DUF3265 domain-containing protein	-
CG015_RS18465	1028685..1029038	-	354	WP_207204989.1	hypothetical protein	-
CG015_RS18475	1029659..1029919	-	261	Protein_912	Txe/YoeB family addiction module toxin	-
CG015_RS18480	1029912..1030163	-	252	WP_129533173.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
CG015_RS18505	1031461..1032429	+	969	WP_129533176.1	IS30 family transposase	-
CG015_RS18510	1032455..1033015	-	561	WP_207204990.1	hypothetical protein	-
CG015_RS18515	1033035..1033127	-	93	WP_081324545.1	DUF3265 domain-containing protein	-
CG015_RS18520	1033163..1033465	-	303	WP_025548916.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CG015_RS18525	1033453..1033710	-	258	WP_129533177.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CG015_RS18530	1033901..1034722	-	822	WP_129533178.1	NAD(P)-dependent oxidoreductase	-
CG015_RS18540	1035461..1036063	-	603	WP_164996844.1	hypothetical protein	-
CG015_RS18550	1037084..1037200	-	117	Protein_921	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1031461..1032429	968
	-	inside	Integron	-	-	852173..1046590	194417

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11669.57 Da
• Isoelectric Point: 5.1765

>T79104 WP_025548916.1 NZ_CP022469:c1033465-1033163 [Vibrio anguillarum]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLSKQ

Nucleotide

• Length: 303 bp

>T79104 NZ_CP022469:c1033465-1033163 [Vibrio anguillarum]
ATGGCTGAAATAATCTGGACTGAGCCAGCGTTATCTGACCTCAACGATATCGCAGAATACATCGCACTTGAAAATATTGT
CGCTGCAAAGCAGTTAGTACAAACGATCTTCTCCAAAGTCGAACGACTACAAACTTTCCCAGAGTCAGGTCGTATTCCAC
CCGAACTAGAACATTTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTCTATAAGCAAGACGGCGACAAGGTG
TTTATTCTGTTTGTTATGCGTGCTGAGAGAGATTTGCGTAAGTTCCTGTTGAGTAAGCAGTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9520.01 Da
• Isoelectric Point: 7.3177

>AT79104 WP_129533177.1 NZ_CP022469:c1033710-1033453 [Vibrio anguillarum]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKAVSHDEAKGKM
SKWLK

Nucleotide

• Length: 258 bp

>AT79104 NZ_CP022469:c1033710-1033453 [Vibrio anguillarum]
ATGAAAGTAGAACTAGTTACATCACTCAAACGTCAAGCAACTAAGATCCTCGCCGATCTCCACGACACCAAAGAACCAGT
GTTAATTACTGAGCATGGTAAGCCATCCGCGTATCTAGTTGATGTTGATGACTACGAGTTTATGCAAAATCGTTTAGCTA
TTCTTGAGGGGATCGCACGAGGTGAACGCGCACTAGCTGACGGTAAAGCGGTAAGTCATGATGAAGCCAAGGGCAAAATG
TCAAAATGGCTGAAATAA

Structures

Toxin

• AlphaFold DB: A0A347UR19