Detailed information of TA system TA079101

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 960706..961265
• Replicon: chromosome
• Accession: NZ_CP022469
• Organism: Vibrio anguillarum strain MHK3

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CG015_RS17900
• Protein ID: WP_017038685.1
• Coordinates: 960987..961265 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0F2IS73
• Locus tag: CG015_RS17895
• Protein ID: WP_045569188.1
• Coordinates: 960706..960990 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CG015_RS17875	956248..957150	-	903	WP_129533139.1	hypothetical protein	-
CG015_RS17880	957359..957594	-	236	Protein_825	hypothetical protein	-
CG015_RS17885	957846..958361	-	516	WP_129533140.1	hypothetical protein	-
CG015_RS17890	958497..959462	-	966	WP_129533141.1	RelA/SpoT domain-containing protein	-
CG015_RS17895	960706..960990	+	285	WP_045569188.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
CG015_RS17900	960987..961265	+	279	WP_017038685.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
CG015_RS17905	962303..963258	-	956	Protein_830	hypothetical protein	-
CG015_RS17910	963446..963556	-	111	WP_094165685.1	DUF3265 domain-containing protein	-
CG015_RS17915	964135..964227	-	93	WP_207204987.1	DUF3265 domain-containing protein	-
CG015_RS17920	964242..965168	-	927	WP_129533143.1	hypothetical protein	-
CG015_RS17925	965319..965735	-	417	WP_129533227.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	852173..1046590	194417

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-44)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10892.60 Da
• Isoelectric Point: 4.3535

>T79101 WP_017038685.1 NZ_CP022469:960987-961265 [Vibrio anguillarum]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDEIIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGSIIRIM
RVLHQKQKFPTD

Nucleotide

• Length: 279 bp

>T79101 NZ_CP022469:960987-961265 [Vibrio anguillarum]
ATGATTTTATGGGAAGAAGAATCGCTAAATGATCGAGAGAAGATCTTTGAGTTTCTTTATGACTTTAACCCTGATGCGGC
TGAAAAAACTGATGAAATTATTGAGGCTAAAGTAGAAAACTTACTCGAACAACCATTGATGGGTGTTCAACGGGATGGAA
TTCGAGGACGATTACTCATTATTCCCGAAATCTCAATGATCGTTTCGTACTGGGTAGAAGGTTCAATTATTCGCATAATG
CGAGTTCTACACCAGAAGCAGAAATTCCCTACCGATTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10987.31 Da
• Isoelectric Point: 9.2173

>AT79101 WP_045569188.1 NZ_CP022469:960706-960990 [Vibrio anguillarum]
MDTRIQFRVDDEIKRLAQQMAESQGRTLSDACRELTEQMAEQQRKTLSHDAWLTEQINLAFEKFDSGKSSFVEHNSAKAR
MTERKAKIRNRGQQ

Nucleotide

• Length: 285 bp

>AT79101 NZ_CP022469:960706-960990 [Vibrio anguillarum]
ATGGACACTAGAATTCAATTTCGTGTTGATGACGAAATTAAACGTTTAGCCCAACAAATGGCTGAGAGCCAAGGTCGCAC
ACTCAGCGATGCTTGCCGTGAACTTACTGAACAAATGGCTGAGCAACAAAGAAAAACATTATCTCATGACGCTTGGTTAA
CTGAACAAATAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCTTCATTTGTTGAACATAATTCAGCTAAAGCACGA
ATGACTGAACGAAAGGCCAAAATTCGTAATCGAGGCCAGCAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0F2IS73