Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /GNAT-DUF1778 |
| Location | 930250..931016 | Replicon | chromosome |
| Accession | NZ_CP022469 | ||
| Organism | Vibrio anguillarum strain MHK3 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A290PTK1 |
| Locus tag | CG015_RS17665 | Protein ID | WP_017045788.1 |
| Coordinates | 930519..931016 (+) | Length | 166 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A853R804 |
| Locus tag | CG015_RS17660 | Protein ID | WP_017045787.1 |
| Coordinates | 930250..930522 (+) | Length | 91 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CG015_RS17625 | 925293..925418 | - | 126 | WP_129533123.1 | DUF3265 domain-containing protein | - |
| CG015_RS17630 | 925400..926116 | - | 717 | WP_129533124.1 | aminoglycoside phosphotransferase family protein | - |
| CG015_RS17635 | 926252..927367 | - | 1116 | WP_129533125.1 | SEC-C domain-containing protein | - |
| CG015_RS17640 | 927967..928572 | - | 606 | WP_129533218.1 | DUF922 domain-containing protein | - |
| CG015_RS17645 | 928713..928994 | - | 282 | WP_088733334.1 | hypothetical protein | - |
| CG015_RS17655 | 930049..930210 | - | 162 | WP_129533219.1 | DUF3265 domain-containing protein | - |
| CG015_RS17660 | 930250..930522 | + | 273 | WP_017045787.1 | DUF1778 domain-containing protein | Antitoxin |
| CG015_RS17665 | 930519..931016 | + | 498 | WP_017045788.1 | GNAT family N-acetyltransferase | Toxin |
| CG015_RS17675 | 932176..932361 | + | 186 | WP_129533126.1 | hypothetical protein | - |
| CG015_RS17685 | 932700..932987 | - | 288 | WP_000221356.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| CG015_RS17690 | 932977..933228 | - | 252 | WP_001250181.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| CG015_RS17695 | 933436..933900 | - | 465 | WP_094144821.1 | ASCH domain-containing protein | - |
| CG015_RS17710 | 935068..935550 | - | 483 | WP_094128441.1 | tetratricopeptide repeat protein | - |
| CG015_RS17715 | 935478..935690 | - | 213 | WP_129533221.1 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 852173..1046590 | 194417 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 166 a.a. Molecular weight: 18524.30 Da Isoelectric Point: 9.2813
>T79098 WP_017045788.1 NZ_CP022469:930519-931016 [Vibrio anguillarum]
MMKTVLLDKDKHDRNRFNCGIDALNNYLKVMASQQAKKDNTRTFVLEDENNTSLIIGFYTLTMTPIDLKTLPDKLQKKHQ
SSTSGGLIARLAIDDSYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFKAFQDAENKLFITISDI
RASLG
MMKTVLLDKDKHDRNRFNCGIDALNNYLKVMASQQAKKDNTRTFVLEDENNTSLIIGFYTLTMTPIDLKTLPDKLQKKHQ
SSTSGGLIARLAIDDSYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFKAFQDAENKLFITISDI
RASLG
Download Length: 498 bp
>T79098 NZ_CP022469:930519-931016 [Vibrio anguillarum]
ATGATGAAAACGGTATTACTCGATAAAGATAAACACGACAGAAACCGATTCAACTGCGGAATTGATGCGCTTAATAACTA
TTTGAAAGTCATGGCAAGTCAGCAAGCTAAAAAAGATAATACCCGAACATTTGTTTTAGAGGATGAAAATAACACTTCAC
TTATCATCGGTTTTTACACTTTAACAATGACACCCATTGACCTAAAAACATTGCCTGATAAGTTACAGAAAAAGCATCAG
TCATCAACTTCTGGCGGACTCATTGCTCGCTTAGCTATCGATGATAGCTATAAAGGTAAAGGATTTGGCGAGTGGTTACT
TATCGATGCTCTACGAAAACTACTAGCAGCTAGTGATAGCGTGGCATTTCCCGTCGTTATTGTTGACGCAAAAGATGGCG
CCAAACATTTCTATGAGCGCTATGGTTTTAAAGCGTTTCAAGATGCAGAAAATAAGCTATTTATCACCATTTCAGATATT
AGGGCAAGTTTAGGCTAG
ATGATGAAAACGGTATTACTCGATAAAGATAAACACGACAGAAACCGATTCAACTGCGGAATTGATGCGCTTAATAACTA
TTTGAAAGTCATGGCAAGTCAGCAAGCTAAAAAAGATAATACCCGAACATTTGTTTTAGAGGATGAAAATAACACTTCAC
TTATCATCGGTTTTTACACTTTAACAATGACACCCATTGACCTAAAAACATTGCCTGATAAGTTACAGAAAAAGCATCAG
TCATCAACTTCTGGCGGACTCATTGCTCGCTTAGCTATCGATGATAGCTATAAAGGTAAAGGATTTGGCGAGTGGTTACT
TATCGATGCTCTACGAAAACTACTAGCAGCTAGTGATAGCGTGGCATTTCCCGTCGTTATTGTTGACGCAAAAGATGGCG
CCAAACATTTCTATGAGCGCTATGGTTTTAAAGCGTTTCAAGATGCAGAAAATAAGCTATTTATCACCATTTCAGATATT
AGGGCAAGTTTAGGCTAG
Antitoxin
Download Length: 91 a.a. Molecular weight: 9889.46 Da Isoelectric Point: 9.7681
>AT79098 WP_017045787.1 NZ_CP022469:930250-930522 [Vibrio anguillarum]
MATTLPRITARVDVDTQNLLTKAAALAGMSSINSFVLNAAIEKAKQVIEREQTLKLSQTDAILLMEALDKPTTLNQKLKT
AAERYETKTQ
MATTLPRITARVDVDTQNLLTKAAALAGMSSINSFVLNAAIEKAKQVIEREQTLKLSQTDAILLMEALDKPTTLNQKLKT
AAERYETKTQ
Download Length: 273 bp
>AT79098 NZ_CP022469:930250-930522 [Vibrio anguillarum]
ATGGCTACCACTTTACCTCGTATCACTGCGAGAGTTGATGTCGATACACAAAACTTATTAACCAAAGCGGCTGCTCTCGC
TGGCATGTCTAGTATTAACTCATTTGTACTCAATGCTGCAATCGAAAAAGCAAAACAAGTGATTGAACGCGAGCAAACAC
TAAAATTAAGCCAAACAGACGCCATTTTACTTATGGAAGCTCTCGATAAACCAACAACATTAAATCAAAAGCTTAAAACT
GCCGCCGAACGCTATGAGACCAAAACCCAATGA
ATGGCTACCACTTTACCTCGTATCACTGCGAGAGTTGATGTCGATACACAAAACTTATTAACCAAAGCGGCTGCTCTCGC
TGGCATGTCTAGTATTAACTCATTTGTACTCAATGCTGCAATCGAAAAAGCAAAACAAGTGATTGAACGCGAGCAAACAC
TAAAATTAAGCCAAACAGACGCCATTTTACTTATGGAAGCTCTCGATAAACCAACAACATTAAATCAAAAGCTTAAAACT
GCCGCCGAACGCTATGAGACCAAAACCCAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A290PTK1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A853R804 |