Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 29665..30211 Replicon plasmid unnamed
Accession NZ_CP022465
Organism Enterocloster bolteae strain ATCC BAA-613

Toxin (Protein)


Gene name relE Uniprot ID A8S0R9
Locus tag CGC65_RS30750 Protein ID WP_007038024.1
Coordinates 29665..29943 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A414AJ69
Locus tag CGC65_RS30755 Protein ID WP_007038025.1
Coordinates 29936..30211 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGC65_RS30735 26673..27509 + 837 WP_007038019.1 hypothetical protein -
CGC65_RS30740 28744..29043 - 300 WP_039897589.1 helix-turn-helix domain-containing protein -
CGC65_RS30745 29180..29515 + 336 WP_039897591.1 hypothetical protein -
CGC65_RS30750 29665..29943 - 279 WP_007038024.1 type II toxin-antitoxin system YafQ family toxin Toxin
CGC65_RS30755 29936..30211 - 276 WP_007038025.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CGC65_RS30760 30642..30899 + 258 WP_007038026.1 hypothetical protein -
CGC65_RS30765 30883..31095 + 213 WP_007038027.1 hypothetical protein -
CGC65_RS30770 31169..31912 + 744 WP_039897592.1 AAA family ATPase -
CGC65_RS30775 32317..32568 + 252 WP_007038030.1 hypothetical protein -
CGC65_RS30780 32599..32943 + 345 WP_007038031.1 hypothetical protein -
CGC65_RS30785 33000..33257 + 258 WP_007038032.1 hypothetical protein -
CGC65_RS30790 33369..34166 + 798 WP_007038033.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..43860 43860


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10942.65 Da        Isoelectric Point: 8.4737

>T79097 WP_007038024.1 NZ_CP022465:c29943-29665 [Enterocloster bolteae]
MLKIEYQGQFKKDYKLALKRGCNPELLTEVISMLANEQELPEKYRDHNLMNSRSYKNARECHIQPDWLLIYQTNKDILTL
KLLRTGSHSDLF

Download         Length: 279 bp

>T79097 NZ_CP022465:c29943-29665 [Enterocloster bolteae]
ATGCTTAAGATTGAGTATCAAGGCCAGTTTAAGAAAGATTATAAATTAGCATTAAAACGTGGATGTAATCCTGAACTACT
TACAGAGGTTATATCTATGTTGGCCAATGAGCAAGAACTCCCCGAAAAATATAGGGACCATAACCTTATGAACTCACGGA
GCTATAAAAATGCGAGAGAGTGCCACATACAGCCTGATTGGTTACTCATCTATCAGACAAATAAAGATATCTTAACGCTA
AAATTGTTGCGGACTGGTTCACATAGTGATTTATTTTAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10209.60 Da        Isoelectric Point: 4.5388

>AT79097 WP_007038025.1 NZ_CP022465:c30211-29936 [Enterocloster bolteae]
MSEKNTSMNIRMNKDVKLQAQKVFSDLGIDLTTAVNVFLRQSIRYQGFPFDVTLRQEPNATTMAAIENADKGIDMHGPFE
SVEALMEDLNA

Download         Length: 276 bp

>AT79097 NZ_CP022465:c30211-29936 [Enterocloster bolteae]
ATGTCTGAAAAAAACACAAGTATGAATATCAGAATGAATAAAGATGTGAAACTACAGGCACAGAAAGTTTTTAGTGACCT
TGGAATTGATTTAACCACTGCAGTAAACGTATTTCTGCGCCAATCTATACGTTACCAGGGTTTTCCCTTCGATGTAACCT
TGCGCCAGGAACCAAACGCAACAACTATGGCTGCTATAGAAAATGCGGATAAAGGGATAGACATGCATGGTCCGTTTGAA
TCTGTAGAGGCCCTAATGGAGGACCTTAATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A8S0R9

Antitoxin

Source ID Structure
AlphaFold DB A0A414AJ69

References