Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 6480699..6481264 Replicon chromosome
Accession NZ_CP022464
Organism Enterocloster bolteae strain ATCC BAA-613

Toxin (Protein)


Gene name relE Uniprot ID C7H6P5
Locus tag CGC65_RS30210 Protein ID WP_002596328.1
Coordinates 6480974..6481264 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID C7H6P4
Locus tag CGC65_RS30205 Protein ID WP_005924829.1
Coordinates 6480699..6480977 (+) Length 93 a.a.

Genomic Context

CGC65_RS30205CGC65_RS30210CGC65_RS30165CGC65_RS30170CGC65_RS30175CGC65_RS30180CGC65_RS30185CGC65_RS30190CGC65_RS30195CGC65_RS30200CGC65_RS30215CGC65_RS30220CGC65_RS30225CGC65_RS30230CGC65_RS30235CGC65_RS30240
Location: 6480699..6480977 (279 bp)
Type: Antitoxin
Protein ID: WP_005924829.1
Location: 6480974..6481264 (291 bp)
Type: Toxin
Protein ID: WP_002596328.1
Location: 6476033..6476338 (306 bp)
Type: Others
Protein ID: WP_002569240.1
Location: 6476502..6476642 (141 bp)
Type: Others
Protein ID: WP_007037419.1
Location: 6476861..6477676 (816 bp)
Type: Others
Protein ID: Protein_5862
Location: 6477770..6478135 (366 bp)
Type: Others
Protein ID: WP_014080225.1
Location: 6478213..6478407 (195 bp)
Type: Others
Protein ID: WP_005933543.1
Location: 6478451..6479314 (864 bp)
Type: Others
Protein ID: WP_005933545.1
Location: 6479311..6480060 (750 bp)
Type: Others
Protein ID: WP_005933547.1
Location: 6480174..6480572 (399 bp)
Type: Others
Protein ID: WP_005933550.1
Location: 6481372..6482817 (1446 bp)
Type: Others
Protein ID: WP_007037415.1
Location: 6483004..6483294 (291 bp)
Type: Others
Protein ID: WP_005933556.1
Location: 6483323..6483784 (462 bp)
Type: Others
Protein ID: WP_035394327.1
Location: 6483795..6484247 (453 bp)
Type: Others
Protein ID: WP_005933558.1
Location: 6484351..6484764 (414 bp)
Type: Others
Protein ID: WP_035394329.1
Location: 6485218..6485679 (462 bp)
Type: Others
Protein ID: WP_038259777.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CGC65_RS301656476033..6476338-306WP_002569240.1hypothetical protein-
CGC65_RS301706476502..6476642-141WP_007037419.1membrane protein-
CGC65_RS301756476861..6477676-816Protein_5862type IV secretory system conjugative DNA transfer family protein-
CGC65_RS301806477770..6478135-366WP_014080225.1hypothetical protein-
CGC65_RS301856478213..6478407-195WP_005933543.1transposon-encoded TnpW family protein-
CGC65_RS301906478451..6479314-864WP_005933545.1ATP-binding protein-
CGC65_RS301956479311..6480060-750WP_005933547.1phage replisome organizer N-terminal domain-containing protein-
CGC65_RS302006480174..6480572-399WP_005933550.1cysteine-rich VLP domain-containing protein-
CGC65_RS302056480699..6480977+279WP_005924829.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
CGC65_RS302106480974..6481264+291WP_002596328.1type II toxin-antitoxin system YafQ family toxinToxin
CGC65_RS302156481372..6482817-1446WP_007037415.1MobA/MobL family protein-
CGC65_RS302206483004..6483294-291WP_005933556.1DUF3847 domain-containing protein-
CGC65_RS302256483323..6483784-462WP_035394327.1sigma-70 family RNA polymerase sigma factor-
CGC65_RS302306483795..6484247-453WP_005933558.1hypothetical protein-
CGC65_RS302356484351..6484764-414WP_035394329.1hypothetical protein-
CGC65_RS302406485218..6485679-462WP_038259777.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-94)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-90)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11112.87 Da        Isoelectric Point: 8.0630

>T79096 WP_002596328.1 NZ_CP022464:6480974-6481264 [Enterocloster bolteae]
MKETKYTVKYTTSFKKDYKRAIKRGLKIELLEQVVALLAMGEPLPDKNRDHDLSGDWAGHRECHILPDWLLVYRIEDDVL
VLTLARTGTHSDLFGK

Download         Length: 291 bp

>T79096 NZ_CP022464:6480974-6481264 [Enterocloster bolteae]
ATGAAAGAAACCAAATATACCGTCAAGTACACGACCAGTTTCAAAAAGGACTACAAACGAGCCATCAAGCGTGGCTTGAA
GATTGAGCTGCTGGAGCAGGTCGTAGCATTGCTGGCAATGGGCGAACCGCTGCCGGATAAGAACCGTGACCATGACCTGT
CCGGCGATTGGGCAGGTCATCGGGAATGTCATATTCTCCCGGACTGGCTGCTTGTCTATCGCATAGAGGATGATGTTCTG
GTGCTGACGCTGGCCCGCACCGGCACACACAGCGACTTGTTCGGCAAATAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10247.66 Da        Isoelectric Point: 4.4692

>AT79096 WP_005924829.1 NZ_CP022464:6480699-6480977 [Enterocloster bolteae]
MAGNTTNISIRMDADLKAQADALFTELGMNLTTAFNIFVRQSLREGGIPFEVRLEQPNKETVAAMLEAERIAKDPSVKGY
NDLDELFADLKR

Download         Length: 279 bp

>AT79096 NZ_CP022464:6480699-6480977 [Enterocloster bolteae]
ATGGCTGGAAATACCACAAACATCAGTATCCGCATGGACGCAGATTTGAAAGCGCAGGCGGACGCACTGTTTACGGAACT
TGGCATGAACCTGACTACGGCGTTTAACATCTTTGTGCGCCAGTCGCTTCGTGAAGGCGGCATTCCCTTTGAAGTAAGGC
TGGAACAGCCGAACAAAGAAACGGTTGCTGCCATGCTGGAAGCGGAAAGGATTGCAAAAGACCCGTCTGTAAAGGGCTAC
AATGACCTTGACGAGTTATTTGCTGACCTGAAAAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A1M4XBM1

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1M4XB19

References