Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2501779..2502397 Replicon chromosome
Accession NZ_CP022457
Organism Shigella sonnei strain 2015C-3566

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag B9128_RS13530 Protein ID WP_001291435.1
Coordinates 2501779..2501997 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0H8V4S8
Locus tag B9128_RS13535 Protein ID WP_000344804.1
Coordinates 2502023..2502397 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B9128_RS13495 (2497071) 2497071..2497643 + 573 WP_000779812.1 YbaY family lipoprotein -
B9128_RS13500 (2497674) 2497674..2497985 - 312 WP_000409911.1 MGMT family protein -
B9128_RS13510 (2498364) 2498364..2498717 + 354 WP_000878140.1 DUF1428 domain-containing protein -
B9128_RS13515 (2498759) 2498759..2500307 - 1549 Protein_2416 cyclic-guanylate-specific phosphodiesterase PdeB -
B9128_RS13520 (2500471) 2500471..2500941 - 471 WP_000136192.1 YlaC family protein -
B9128_RS13525 (2501057) 2501057..2501608 - 552 WP_000102564.1 maltose O-acetyltransferase -
B9128_RS13530 (2501779) 2501779..2501997 - 219 WP_001291435.1 HHA domain-containing protein Toxin
B9128_RS13535 (2502023) 2502023..2502397 - 375 WP_000344804.1 Hha toxicity modulator TomB Antitoxin
B9128_RS13540 (2502943) 2502943..2506092 - 3150 WP_001132464.1 efflux RND transporter permease AcrB -
B9128_RS13545 (2506115) 2506115..2507308 - 1194 WP_052938679.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T79086 WP_001291435.1 NZ_CP022457:c2501997-2501779 [Shigella sonnei]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T79086 NZ_CP022457:c2501997-2501779 [Shigella sonnei]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14615.43 Da        Isoelectric Point: 4.6232

>AT79086 WP_000344804.1 NZ_CP022457:c2502397-2502023 [Shigella sonnei]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIETFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT79086 NZ_CP022457:c2502397-2502023 [Shigella sonnei]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGAGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H8V4S8

References