Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 413697..414351 Replicon chromosome
Accession NZ_CP022457
Organism Shigella sonnei strain 2015C-3566

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag B9128_RS02275 Protein ID WP_000244777.1
Coordinates 413697..414104 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag B9128_RS02280 Protein ID WP_000354046.1
Coordinates 414085..414351 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B9128_RS02255 (409654) 409654..411387 - 1734 WP_000813167.1 single-stranded-DNA-specific exonuclease RecJ -
B9128_RS02260 (411393) 411393..412103 - 711 WP_000715206.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
B9128_RS02265 (412128) 412128..413024 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
B9128_RS02270 (413136) 413136..413657 + 522 WP_001055874.1 flavodoxin FldB -
B9128_RS02275 (413697) 413697..414104 - 408 WP_000244777.1 protein YgfX Toxin
B9128_RS02280 (414085) 414085..414351 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
B9128_RS02285 (414594) 414594..415574 + 981 WP_000886060.1 tRNA-modifying protein YgfZ -
B9128_RS02290 (415770) 415770..416429 - 660 WP_000250274.1 hemolysin III family protein -
B9128_RS02295 (416593) 416593..416904 - 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
B9128_RS02300 (416949) 416949..418382 + 1434 WP_005137189.1 6-phospho-beta-glucosidase BglA -
B9128_RS02305 (418439) 418439..419182 - 744 WP_000951937.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T79081 WP_000244777.1 NZ_CP022457:c414104-413697 [Shigella sonnei]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T79081 NZ_CP022457:c414104-413697 [Shigella sonnei]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT79081 WP_000354046.1 NZ_CP022457:c414351-414085 [Shigella sonnei]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT79081 NZ_CP022457:c414351-414085 [Shigella sonnei]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References