Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4296803..4297421 Replicon chromosome
Accession NZ_CP022455
Organism Shigella sonnei strain 2015C-3794

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag B9129_RS23645 Protein ID WP_001291435.1
Coordinates 4296803..4297021 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0H8V4S8
Locus tag B9129_RS23650 Protein ID WP_000344804.1
Coordinates 4297047..4297421 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B9129_RS23610 (4292095) 4292095..4292667 + 573 WP_000779812.1 YbaY family lipoprotein -
B9129_RS23615 (4292698) 4292698..4293009 - 312 WP_000409911.1 MGMT family protein -
B9129_RS23625 (4293388) 4293388..4293741 + 354 WP_000878140.1 DUF1428 domain-containing protein -
B9129_RS23630 (4293783) 4293783..4295331 - 1549 Protein_4242 cyclic-guanylate-specific phosphodiesterase PdeB -
B9129_RS23635 (4295495) 4295495..4295965 - 471 WP_000136192.1 YlaC family protein -
B9129_RS23640 (4296081) 4296081..4296632 - 552 WP_000102564.1 maltose O-acetyltransferase -
B9129_RS23645 (4296803) 4296803..4297021 - 219 WP_001291435.1 HHA domain-containing protein Toxin
B9129_RS23650 (4297047) 4297047..4297421 - 375 WP_000344804.1 Hha toxicity modulator TomB Antitoxin
B9129_RS23655 (4297967) 4297967..4301116 - 3150 WP_001132464.1 efflux RND transporter permease AcrB -
B9129_RS23660 (4301139) 4301139..4302332 - 1194 WP_011310152.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T79074 WP_001291435.1 NZ_CP022455:c4297021-4296803 [Shigella sonnei]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T79074 NZ_CP022455:c4297021-4296803 [Shigella sonnei]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14615.43 Da        Isoelectric Point: 4.6232

>AT79074 WP_000344804.1 NZ_CP022455:c4297421-4297047 [Shigella sonnei]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIETFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT79074 NZ_CP022455:c4297421-4297047 [Shigella sonnei]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGAGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H8V4S8

References