Detailed information of TA system TA079065

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): paaR-paaA-parE/-
• Location: 656474..656958
• Replicon: chromosome
• Accession: NZ_CP022455
• Organism: Shigella sonnei strain 2015C-3794

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: A0A377EAU1
• Locus tag: B9129_RS03880
• Protein ID: WP_014334020.1
• Coordinates: 656474..656764 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: paaA
• Uniprot ID: A0A376K4R9
• Locus tag: B9129_RS03885
• Protein ID: WP_005142544.1
• Coordinates: 656764..656958 (-)
• Length: 65 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B9129_RS03830 (651674)	651674..652750	-	1077	Protein_683	molybdopterin-dependent oxidoreductase	-
B9129_RS03840 (652808)	652808..653505	+	698	WP_094096600.1	IS1-like element IS1A family transposase	-
B9129_RS03845 (653499)	653499..654287	-	789	Protein_685	Rha family transcriptional regulator	-
B9129_RS03865 (654820)	654820..655517	+	698	WP_094096600.1	IS1-like element IS1A family transposase	-
B9129_RS03870 (655665)	655665..656030	-	366	WP_024174355.1	hypothetical protein	-
B9129_RS03875 (656042)	656042..656194	-	153	WP_000379558.1	DUF1391 family protein	-
B9129_RS03880 (656474)	656474..656764	-	291	WP_014334020.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
B9129_RS03885 (656764)	656764..656958	-	195	WP_005142544.1	hypothetical protein	Antitoxin
B9129_RS03890 (656978)	656978..657463	-	486	WP_053002468.1	helix-turn-helix domain-containing protein	-
B9129_RS03895 (657590)	657590..657853	+	264	WP_001048456.1	helix-turn-helix transcriptional regulator	-
B9129_RS03900 (657850)	657850..658275	+	426	WP_000693826.1	toxin YdaT family protein	-
B9129_RS03905 (658347)	658347..659411	+	1065	WP_039063478.1	phage replisome organizer	-
B9129_RS03910 (659418)	659418..660164	+	747	WP_000788740.1	ATP-binding protein	-
B9129_RS03915 (660186)	660186..660911	+	726	WP_000450631.1	DUF1627 domain-containing protein	-
B9129_RS03920 (660927)	660927..661349	+	423	WP_001151171.1	DUF977 family protein	-
B9129_RS03925 (661407)	661407..661763	+	357	WP_005140877.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	653499..680784	27285

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11062.93 Da
• Isoelectric Point: 10.2013

>T79065 WP_014334020.1 NZ_CP022455:c656764-656474 [Shigella sonnei]
MLPVLWLPSARDDLRQIVAYIAKENPAAARRMKIRIETSVLPLTEHPYLYPPSERVLGLREIVTHPNYIILYRVTASSIE
VVNIVHSRRQYPGKNS

Nucleotide

• Length: 291 bp

>T79065 NZ_CP022455:c656764-656474 [Shigella sonnei]
ATGTTACCCGTTTTATGGCTACCATCTGCTCGTGATGATTTGCGCCAGATCGTAGCCTACATAGCTAAAGAAAATCCCGC
GGCAGCACGCAGAATGAAAATTCGAATTGAAACATCCGTTTTGCCGCTCACAGAGCATCCTTACCTGTATCCTCCAAGCG
AGCGAGTTCTTGGTCTTCGTGAAATTGTAACTCATCCTAACTACATCATCCTTTACCGAGTAACAGCATCAAGCATAGAA
GTAGTAAATATTGTGCATTCTCGAAGACAGTATCCAGGCAAAAACAGTTAA

Antitoxin

Protein

• Length: 65 a.a.
• Molecular weight: 7097.98 Da
• Isoelectric Point: 4.1759

>AT79065 WP_005142544.1 NZ_CP022455:c656958-656764 [Shigella sonnei]
MSTVLSPMVSEFETVEQENSYNEWLRAKVAASLADPRPAIPHDEVMAEMEQIIAQIAAATHRGE

Nucleotide

• Length: 195 bp

>AT79065 NZ_CP022455:c656958-656764 [Shigella sonnei]
ATGAGTACAGTCCTTTCCCCAATGGTTTCAGAATTTGAGACAGTTGAGCAAGAAAATAGTTACAACGAATGGCTGCGGGC
CAAAGTAGCAGCAAGCCTCGCGGATCCCCGCCCGGCGATTCCGCATGATGAGGTAATGGCGGAAATGGAACAAATTATTG
CCCAAATTGCTGCTGCAACTCACAGAGGTGAATAA

Structures

Toxin

• AlphaFold DB: A0A377EAU1

Antitoxin

• AlphaFold DB: A0A376K4R9