Detailed information of TA system TA079054

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 56009..56601
• Replicon: plasmid pD90-2
• Accession: NZ_CP022452
• Organism: Salmonella enterica subsp. enterica serovar Indiana strain D90

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A1I9ZJC5
• Locus tag: CGL53_RS25990
• Protein ID: WP_000513532.1
• Coordinates: 56009..56257 (+)
• Length: 83 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A1I9ZJ49
• Locus tag: CGL53_RS25995
• Protein ID: WP_000681609.1
• Coordinates: 56254..56601 (+)
• Length: 116 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CGL53_RS25945	51021..51686	-	666	WP_000532149.1	P-loop NTPase	-
CGL53_RS25955	52275..52604	+	330	WP_001542022.1	hypothetical protein	-
CGL53_RS25960	53005..53520	+	516	WP_001025393.1	J domain-containing protein	-
CGL53_RS25965	53624..54166	+	543	WP_001083904.1	hypothetical protein	-
CGL53_RS25970	54163..54417	+	255	WP_001230709.1	hypothetical protein	-
CGL53_RS25975	54414..54656	+	243	WP_000151456.1	hypothetical protein	-
CGL53_RS25985	55227..55520	+	294	WP_000673428.1	hypothetical protein	-
CGL53_RS25990	56009..56257	+	249	WP_000513532.1	type II toxin-antitoxin system HicA family toxin	Toxin
CGL53_RS25995	56254..56601	+	348	WP_000681609.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
CGL53_RS26000	56689..56871	-	183	WP_001428470.1	hypothetical protein	-
CGL53_RS26005	57373..57672	+	300	WP_034169410.1	type II toxin-antitoxin system HicB family antitoxin	-
CGL53_RS26010	57932..58258	-	327	WP_000206697.1	hypothetical protein	-
CGL53_RS26015	58260..58619	-	360	WP_024147837.1	hypothetical protein	-
CGL53_RS26020	58720..59427	-	708	WP_000108794.1	hypothetical protein	-
CGL53_RS26025	59429..60181	-	753	WP_000797966.1	conjugal transfer protein TraL	-
CGL53_RS26030	60199..60600	-	402	WP_021575837.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..60860	60860

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-103)

Antitoxin

• HigA2-like, helix-turn-helix domain (35-98)

Sequences

Toxin

Protein

• Length: 83 a.a.
• Molecular weight: 10656.47 Da
• Isoelectric Point: 12.7138

>T79054 WP_000513532.1 NZ_CP022452:56009-56257 [Salmonella enterica subsp. enterica serovar Indiana]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKK

Nucleotide

• Length: 249 bp

>T79054 NZ_CP022452:56009-56257 [Salmonella enterica subsp. enterica serovar Indiana]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAA

Antitoxin

Protein

• Length: 116 a.a.
• Molecular weight: 14886.21 Da
• Isoelectric Point: 12.8607

>AT79054 WP_000681609.1 NZ_CP022452:56254-56601 [Salmonella enterica subsp. enterica serovar Indiana]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 348 bp

>AT79054 NZ_CP022452:56254-56601 [Salmonella enterica subsp. enterica serovar Indiana]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: A0A1I9ZJC5

Antitoxin

• AlphaFold DB: A0A1I9ZJ49