Detailed information of TA system TA079051

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /SpoIISA(toxin)
• Location: 2360006..2360984
• Replicon: chromosome
• Accession: NZ_CP022445
• Organism: Bacillus cereus C1L

Toxin (Protein)

• Gene name: spoIISA
• Uniprot ID: W8Y388
• Locus tag: CGZ63_RS12655
• Protein ID: WP_000624977.1
• Coordinates: 2360006..2360743 (+)
• Length: 246 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: M1PKC2
• Locus tag: CGZ63_RS12660
• Protein ID: WP_000237819.1
• Coordinates: 2360856..2360984 (+)
• Length: 43 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CGZ63_RS12630	2355647..2356429	+	783	WP_000355673.1	class I SAM-dependent methyltransferase	-
CGZ63_RS12635	2356587..2358264	-	1678	Protein_2332	alpha-keto acid decarboxylase family protein	-
CGZ63_RS12640	2358381..2358863	+	483	WP_000191889.1	MarR family winged helix-turn-helix transcriptional regulator	-
CGZ63_RS12645	2359030..2359767	+	738	WP_000594152.1	2,3-diphosphoglycerate-dependent phosphoglycerate mutase	-
CGZ63_RS12655	2360006..2360743	+	738	WP_000624977.1	stage II sporulation protein SA	Toxin
CGZ63_RS12660	2360856..2360984	+	129	WP_000237819.1	hypothetical protein	Antitoxin
CGZ63_RS12665	2361057..2361233	+	177	WP_000852629.1	stage II sporulation protein SB	-
CGZ63_RS12670	2361252..2361641	-	390	WP_025687525.1	YxeA family protein	-
CGZ63_RS12675	2361853..2363322	+	1470	WP_000287548.1	beta-Ala-His dipeptidase	-
CGZ63_RS12680	2363568..2364377	+	810	WP_000678369.1	C39 family peptidase	-
CGZ63_RS12685	2364403..2365005	+	603	WP_000517271.1	hypothetical protein	-
CGZ63_RS12690	2365249..2365500	-	252	WP_000827560.1	response regulator transcription factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SpoIISA, type II toxin-antitoxin system (10-243)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 246 a.a.
• Molecular weight: 28307.03 Da
• Isoelectric Point: 8.2998

>T79051 WP_000624977.1 NZ_CP022445:2360006-2360743 [Bacillus cereus C1L]
MISNIRIGLFVLAIVFVVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Nucleotide

• Length: 738 bp

>T79051 NZ_CP022445:2360006-2360743 [Bacillus cereus C1L]
ATGATCTCTAACATTCGAATTGGCTTATTTGTTTTAGCGATTGTCTTTGTAGTCCTTGTTTTCTTTTATTGGAAAAATGA
GGAGTTGTACGAGGAGAAAAAGCAACGTATTAGAAAGACTTGGTATGGTTTGTTTATCATATCTGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTTACTGCAATGGTTATTTTTGTTGATATTGCGTTC
ATTTTAACGCCTAATATTTCAGAAATATGGGGTGCGAAATTTAGCGATATTGGCAAGACAGTTCAATCAATAAAACGATC
ATTAATTGCATCTAAAGCGAGAGGGGAAATATACACGACAATTATTCAAAATGTTAATCCAGCAGTATTCGGTACGATGG
AATGGCATACGGAAGAGGAATATACAAAGAGCTTAAATGCATTTTTAGATTCATATGGGGAAAAGATTGGCGCGAAAATT
GTTGTTTTTGAAGCCGCGAAGGAATTAAATACAAACTTTCGTGGTATTCGCTCGCAATTTAGTATTATCGTTCCGTTAGA
ACATATCGAGCAATTGAATGAGCAGAAAGCGGTGCAAGTAGAAAATGTCGGGATTATACCAGCAAAAATAGTAAGTGACG
TTTTCATTGTTATTGATGGAAAGAAAAATAACCTGCAAGATCGGGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin

Protein

• Length: 43 a.a.
• Molecular weight: 4953.36 Da
• Isoelectric Point: 3.9798

>AT79051 WP_000237819.1 NZ_CP022445:2360856-2360984 [Bacillus cereus C1L]
VVKDYDNDFFKEGNEDTTDFSLIKGDTLQQVEELEEELKRKS

Nucleotide

• Length: 129 bp

>AT79051 NZ_CP022445:2360856-2360984 [Bacillus cereus C1L]
GTGGTAAAAGATTATGACAATGATTTTTTTAAAGAAGGTAACGAAGATACAACAGATTTCTCTTTAATAAAAGGGGATAC
GTTGCAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATCATAA

Structures

Toxin

• AlphaFold DB: W8Y388

Antitoxin

• AlphaFold DB: M1PKC2