Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3013387..3013900 Replicon chromosome
Accession NZ_CP022444
Organism Klebsiella sp. LY

Toxin (Protein)


Gene name relE Uniprot ID A0A663BE04
Locus tag CE636_RS17640 Protein ID WP_017900571.1
Coordinates 3013619..3013900 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag CE636_RS17635 Protein ID WP_002886901.1
Coordinates 3013387..3013629 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CE636_RS17620 3009417..3010157 + 741 WP_017900574.1 KDGP aldolase family protein -
CE636_RS17625 3010225..3011376 + 1152 WP_017900573.1 lactonase family protein -
CE636_RS17630 3011399..3013309 + 1911 WP_017900572.1 BglG family transcription antiterminator -
CE636_RS17635 3013387..3013629 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CE636_RS17640 3013619..3013900 + 282 WP_017900571.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CE636_RS17645 3013904..3014368 - 465 WP_004206512.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
CE636_RS17650 3014679..3016817 - 2139 WP_004206513.1 anaerobic ribonucleoside-triphosphate reductase -
CE636_RS17655 3017203..3018858 - 1656 WP_017900569.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(18-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11082.93 Da        Isoelectric Point: 10.4123

>T79044 WP_017900571.1 NZ_CP022444:3013619-3013900 [Klebsiella sp. LY]
MTYELEFDPRAWREWQLGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDRVVVVYVIAIGKR
EKAAVYHQANKRL

Download         Length: 282 bp

>T79044 NZ_CP022444:3013619-3013900 [Klebsiella sp. LY]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGCTTGGCGAGACGGTCAAAAAACAGTTCAAAAA
TAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTGCCGGATTGCTACAAAATCAAGC
TTAAGGCGTCAGGTTATCGGCTGGTGTATCAAGTACGAGATAGGGTGGTGGTGGTTTACGTTATTGCCATTGGCAAAAGA
GAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT79044 WP_002886901.1 NZ_CP022444:3013387-3013629 [Klebsiella sp. LY]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT79044 NZ_CP022444:3013387-3013629 [Klebsiella sp. LY]
ATGGCCACGCTCAACGTTCGACTGGATGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACGCC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGCGATG
GCGAAGCGGCGTTGTTACGCACCGTTCGCGAGCGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663BE04

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References