Detailed information of TA system TA079032

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 594381..595033
• Replicon: chromosome
• Accession: NZ_CP022434
• Organism: Nocardiopsis dassonvillei strain HZNU_N_1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: CGQ36_RS02645
• Protein ID: WP_094800647.1
• Coordinates: 594381..594815 (-)
• Length: 145 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A223Q7A9
• Locus tag: CGQ36_RS02650
• Protein ID: WP_036552950.1
• Coordinates: 594812..595033 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CGQ36_RS02630	589490..592108	+	2619	WP_094800643.1	L-aspartate oxidase	-
CGQ36_RS02635	592173..592955	+	783	WP_013155972.1	type III pantothenate kinase	-
CGQ36_RS02640	593140..594312	+	1173	WP_174547202.1	transposase	-
CGQ36_RS02645	594381..594815	-	435	WP_094800647.1	PIN domain nuclease	Toxin
CGQ36_RS02650	594812..595033	-	222	WP_036552950.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
CGQ36_RS02655	595136..596092	-	957	WP_019610452.1	cation diffusion facilitator family transporter	-
CGQ36_RS02660	596189..597793	+	1605	WP_081461785.1	bifunctional lysylphosphatidylglycerol synthetase/lysine--tRNA ligase LysX	-
CGQ36_RS02665	598496..598819	+	324	WP_026338554.1	LuxR family transcriptional regulator	-
CGQ36_RS02670	599013..599651	+	639	WP_094800649.1	amino-acid N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-126)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (2-40)

Sequences

Toxin

Protein

• Length: 145 a.a.
• Molecular weight: 16365.53 Da
• Isoelectric Point: 7.1174

>T79032 WP_094800647.1 NZ_CP022434:c594815-594381 [Nocardiopsis dassonvillei]
VNTVYLVDSSAWVEYLRKTGSETHVFVRELIERGVHLATTEPVAAEILSGAKSSTELQQLERLTDGLIQLSLDNRLDFHH
SAGIYREARSRGKTIRKLYDCLIAAVALRTDAVLVHCDRDFDHLAEVFPRLRVQRHDRESASRP

Nucleotide

• Length: 435 bp

>T79032 NZ_CP022434:c594815-594381 [Nocardiopsis dassonvillei]
GTGAACACCGTCTATCTGGTGGACAGCTCCGCCTGGGTGGAGTACCTGCGCAAGACCGGCTCCGAGACCCACGTCTTCGT
CAGGGAACTCATCGAGCGCGGCGTCCACCTGGCCACGACCGAACCCGTCGCCGCCGAGATCCTGAGCGGGGCGAAGAGCT
CCACCGAGCTCCAGCAGCTGGAACGCCTCACCGACGGCCTGATCCAGCTGTCCCTGGACAACAGGCTCGACTTCCACCAT
TCGGCGGGCATCTACCGTGAGGCCCGCTCCAGGGGTAAGACGATCCGCAAGCTCTACGACTGCCTCATCGCGGCCGTCGC
CCTGCGCACCGACGCGGTCCTCGTGCACTGCGACCGCGACTTCGACCACCTCGCCGAGGTGTTCCCCCGGCTGCGCGTGC
AGCGGCACGACCGGGAGTCAGCTTCTCGGCCCTGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8026.00 Da
• Isoelectric Point: 4.2958

>AT79032 WP_036552950.1 NZ_CP022434:c595033-594812 [Nocardiopsis dassonvillei]
VSRTNIDIDDELVTTAMERFQVSTKREAVDIALRRAVGTPLTKEFLLSLEGIGWEGDLDEMRRSGFEGGAPAS

Nucleotide

• Length: 222 bp

>AT79032 NZ_CP022434:c595033-594812 [Nocardiopsis dassonvillei]
GTGAGTCGCACAAACATTGACATCGACGACGAGCTGGTCACTACCGCCATGGAACGCTTCCAGGTGAGCACCAAGCGCGA
AGCCGTGGACATCGCCCTTCGCCGGGCCGTGGGCACACCTCTCACCAAGGAGTTCCTCCTCAGCCTGGAGGGCATCGGCT
GGGAGGGCGACCTGGACGAGATGCGCCGCTCCGGCTTCGAGGGCGGAGCGCCCGCCTCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A223Q7A9