Detailed information of TA system TA079031

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 5066850..5067375
• Replicon: chromosome
• Accession: NZ_CP022433
• Organism: Streptomyces pluripotens strain MUSC 137

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A221P2S4
• Locus tag: LK07_RS22785
• Protein ID: WP_039658108.1
• Coordinates: 5066850..5067113 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A221P2F9
• Locus tag: LK07_RS22790
• Protein ID: WP_039658109.1
• Coordinates: 5067106..5067375 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LK07_RS22755	5061879..5062508	-	630	WP_078858898.1	hypothetical protein	-
LK07_RS22760	5062512..5063243	-	732	WP_039658202.1	HEAT repeat domain-containing protein	-
LK07_RS22765	5063240..5063626	-	387	WP_039658200.1	hypothetical protein	-
LK07_RS22770	5064763..5065155	-	393	WP_039658199.1	PIN domain-containing protein	-
LK07_RS22775	5065152..5065418	-	267	WP_039658197.1	hypothetical protein	-
LK07_RS22780	5066113..5066832	+	720	WP_078858834.1	tyrosine-type recombinase/integrase	-
LK07_RS22785	5066850..5067113	-	264	WP_039658108.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LK07_RS22790	5067106..5067375	-	270	WP_039658109.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
LK07_RS22795	5067853..5068260	-	408	Protein_4437	DNA-binding protein	-
LK07_RS34855	5068340..5068687	-	348	WP_167747928.1	hypothetical protein	-
LK07_RS33635	5068818..5068910	-	93	Protein_4439	MerR family transcriptional regulator	-
LK07_RS22805	5069098..5069286	+	189	WP_043433455.1	hypothetical protein	-
LK07_RS22810	5069283..5069969	+	687	WP_052318911.1	cytochrome b N-terminal domain-containing protein	-
LK07_RS22815	5069966..5070928	+	963	WP_043408952.1	hypothetical protein	-
LK07_RS22820	5070993..5071967	-	975	WP_039658112.1	SMP-30/gluconolactonase/LRE family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	5049158..5087118	37960

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-58)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10026.46 Da
• Isoelectric Point: 8.5041

>T79031 WP_039658108.1 NZ_CP022433:c5067113-5066850 [Streptomyces pluripotens]
VTDYRTAFRPEAQAELRKIPRDMALRILAKLAELESDPLGFNTTALVSQPERRRLRVGDYRVVYTIDNGELVVWIVHVGH
RSTVYDT

Nucleotide

• Length: 264 bp

>T79031 NZ_CP022433:c5067113-5066850 [Streptomyces pluripotens]
GTGACTGACTACCGGACCGCCTTCCGGCCCGAGGCGCAGGCCGAACTCCGGAAGATCCCCCGCGACATGGCGCTGCGCAT
CCTGGCGAAACTGGCCGAGCTGGAGAGCGACCCCCTGGGCTTCAACACCACCGCGCTCGTGTCGCAGCCAGAACGCCGTC
GGCTCCGAGTCGGCGACTACCGCGTCGTCTACACGATCGACAACGGAGAGCTGGTGGTGTGGATCGTGCACGTCGGGCAC
CGCTCCACCGTCTACGACACCTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10202.66 Da
• Isoelectric Point: 4.7473

>AT79031 WP_039658109.1 NZ_CP022433:c5067375-5067106 [Streptomyces pluripotens]
MTQPLPIESIRNVRAHLAEVVERADRDDVPTVITRRGKEVAAVVSIEVLRKYQEWEEREINRIIDERMANPAPGIPIEDV
MKETLARGD

Nucleotide

• Length: 270 bp

>AT79031 NZ_CP022433:c5067375-5067106 [Streptomyces pluripotens]
ATGACGCAGCCACTCCCCATAGAGTCCATCCGCAATGTGCGCGCGCACTTGGCCGAGGTCGTGGAGCGCGCCGATCGGGA
CGACGTACCAACGGTGATCACGCGCCGCGGCAAGGAAGTCGCCGCCGTGGTGTCGATCGAGGTGCTGCGCAAGTACCAGG
AATGGGAAGAGCGCGAGATCAACCGGATCATCGACGAGCGCATGGCCAACCCGGCACCCGGCATCCCGATCGAGGACGTC
ATGAAGGAGACGCTGGCGCGCGGTGACTGA

Structures

Toxin

• AlphaFold DB: A0A221P2S4

Antitoxin

• AlphaFold DB: A0A221P2F9