Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2872280..2872897 Replicon chromosome
Accession NZ_CP022427
Organism Pantoea ananatis strain YJ76

Toxin (Protein)


Gene name Hha Uniprot ID D4GLR0
Locus tag B7764_RS13675 Protein ID WP_013024903.1
Coordinates 2872682..2872897 (+) Length 72 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A8A4KA49
Locus tag B7764_RS13670 Protein ID WP_015700827.1
Coordinates 2872280..2872657 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7764_RS13640 2868561..2868815 + 255 WP_014606427.1 type B 50S ribosomal protein L31 -
B7764_RS13645 2868827..2868967 + 141 WP_014606428.1 type B 50S ribosomal protein L36 -
B7764_RS13650 2869027..2869905 - 879 WP_019106635.1 metal ABC transporter substrate-binding protein -
B7764_RS13655 2869918..2870757 - 840 WP_013024907.1 metal ABC transporter permease -
B7764_RS13660 2870754..2871425 - 672 WP_089517536.1 ATP-binding cassette domain-containing protein -
B7764_RS13665 2871780..2872133 + 354 WP_013024905.1 hypothetical protein -
B7764_RS13670 2872280..2872657 + 378 WP_015700827.1 Hha toxicity modulator TomB Antitoxin
B7764_RS13675 2872682..2872897 + 216 WP_013024903.1 hemolysin expression modulator Hha Toxin
B7764_RS13685 2873295..2873606 + 312 WP_089517537.1 MGMT family protein -
B7764_RS13690 2873655..2874212 - 558 WP_013024901.1 YbaY family lipoprotein -
B7764_RS13695 2874405..2875268 + 864 WP_014606434.1 acyl-CoA thioesterase II -
B7764_RS13700 2875315..2876604 - 1290 WP_014606435.1 ammonium transporter AmtB -
B7764_RS13705 2876639..2876977 - 339 WP_013024898.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(12-68)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 72 a.a.        Molecular weight: 8552.98 Da        Isoelectric Point: 9.4825

>T79029 WP_013024903.1 NZ_CP022427:2872682-2872897 [Pantoea ananatis]
MNKTLTKTDYLMRLRRCRSIDTLERVIEKNKYELPDEELAVFYSAADHRLAELTMNKLYDKVPVSVWKFVR

Download         Length: 216 bp

>T79029 NZ_CP022427:2872682-2872897 [Pantoea ananatis]
ATGAACAAAACCCTAACTAAAACTGATTATTTGATGCGACTGAGGCGCTGTCGCTCTATTGACACGCTGGAACGCGTGAT
TGAAAAAAATAAGTACGAATTACCCGATGAAGAATTAGCAGTATTTTACTCAGCAGCCGATCACCGCCTGGCTGAACTGA
CGATGAACAAGCTCTATGACAAAGTCCCGGTGTCAGTCTGGAAATTTGTACGCTAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14722.35 Da        Isoelectric Point: 4.3976

>AT79029 WP_015700827.1 NZ_CP022427:2872280-2872657 [Pantoea ananatis]
MDEYSPKRHDIAQLKYLCENLFDDSMATLTDSHHGWVNDPTAESNLQLNDLIEHIASFTMNYKIKHVEDEALITQIDEYL
DDTFMLFSNYSVNTQDLQRWQRSAKRLFNVFTEECAFLQQPSHSL

Download         Length: 378 bp

>AT79029 NZ_CP022427:2872280-2872657 [Pantoea ananatis]
ATGGACGAATACTCACCGAAACGGCATGATATTGCCCAGCTTAAATACTTGTGTGAGAATCTGTTTGACGACAGCATGGC
GACATTAACTGACAGTCATCACGGCTGGGTTAATGACCCCACTGCCGAAAGCAATTTACAGCTAAACGATTTGATTGAGC
ACATCGCCTCTTTCACCATGAATTACAAAATTAAGCACGTTGAAGACGAAGCACTGATTACCCAAATCGATGAATATCTT
GATGATACCTTTATGCTGTTTAGCAACTACAGTGTAAATACTCAGGATCTTCAGCGCTGGCAACGCTCAGCGAAACGTTT
ATTTAATGTGTTTACTGAAGAGTGCGCTTTTCTTCAACAGCCAAGCCATTCATTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References