Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1776749..1778097 Replicon chromosome
Accession NZ_CP022427
Organism Pantoea ananatis strain YJ76

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag B7764_RS08445 Protein ID WP_014605802.1
Coordinates 1776988..1778097 (+) Length 370 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag B7764_RS08440 Protein ID WP_014605801.1
Coordinates 1776749..1776988 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7764_RS08425 1772341..1773729 + 1389 WP_089517337.1 MFS transporter -
B7764_RS08430 1773752..1776127 + 2376 WP_089517338.1 glycoside hydrolase family 3 C-terminal domain-containing protein -
B7764_RS08435 1776191..1776634 - 444 WP_014605800.1 GNAT family N-acetyltransferase -
B7764_RS08440 1776749..1776988 + 240 WP_014605801.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
B7764_RS08445 1776988..1778097 + 1110 WP_014605802.1 HipA domain-containing protein Toxin
B7764_RS08450 1778143..1778559 - 417 WP_014605803.1 GFA family protein -
B7764_RS08460 1779013..1780881 - 1869 WP_013025825.1 low affinity potassium transporter Kup -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(9-55)


Sequences

Toxin        


Download         Length: 370 a.a.        Molecular weight: 40921.24 Da        Isoelectric Point: 7.4551

>T79027 WP_014605802.1 NZ_CP022427:1776988-1778097 [Pantoea ananatis]
MAKLIAWINGERTGTLTLHHNGALHFQYDANWLQHPLARPLSLSLPLQRAAMHSEKVVHFFENLLYPSALIEKDFYPTHP
IKSCEVFATLQKVGHTLPGALSLLPAKRQPVAPDQATHSIFTPADEAQQFDIDNAYLCLSLARELTIPVPDAVLVHENGI
RKLRTERYDRRWRHDGQHLYHLPEEDVCQALGVPLSGRDEQQGGPGIDDIMALLMGSSSAMKDREDLMRCLVFQWLTGIT
RVNAKHLSLLIARGGSFRLAPFKHLLSACPGLSLRTTDRRDFQLGMGLTGPEGKQHHIDAIGPAHFLALAGSVGFSQAAM
RQILAAFIPGLPAAIIKVRDSLPDDYPLTLADAVFSHAMMMLERVRQAT

Download         Length: 1110 bp

>T79027 NZ_CP022427:1776988-1778097 [Pantoea ananatis]
ATGGCAAAGCTCATTGCCTGGATAAACGGCGAGCGTACGGGAACGCTGACGCTGCATCACAACGGCGCGCTGCATTTCCA
GTATGACGCCAACTGGCTTCAGCATCCGCTTGCCAGACCTCTCTCGCTTTCGTTGCCCTTACAGCGCGCCGCGATGCATT
CTGAGAAAGTCGTGCACTTTTTCGAAAACCTTCTCTATCCCAGCGCGTTGATCGAAAAGGATTTTTACCCGACTCACCCG
ATAAAATCCTGTGAGGTCTTTGCAACATTGCAGAAAGTGGGACACACATTACCCGGGGCGCTCAGTCTGCTGCCGGCAAA
GCGGCAGCCCGTCGCGCCGGACCAGGCAACGCACAGCATCTTCACCCCCGCCGATGAGGCACAGCAGTTCGATATCGATA
ATGCGTATCTGTGTCTGTCCCTGGCCCGGGAGCTGACTATCCCGGTGCCGGATGCCGTATTAGTTCATGAGAACGGCATC
CGTAAATTGAGAACAGAACGATACGATCGCCGTTGGCGTCACGACGGACAACACCTTTATCATCTTCCTGAAGAAGACGT
GTGTCAGGCGCTCGGCGTGCCGCTCTCTGGCCGCGATGAGCAGCAGGGCGGTCCGGGAATTGATGACATCATGGCCTTGC
TGATGGGCTCAAGCTCCGCCATGAAAGACCGTGAGGATCTGATGCGCTGTCTGGTATTTCAGTGGCTGACGGGCATCACG
CGCGTCAACGCTAAACATCTCTCGCTGCTGATTGCTCGCGGTGGCAGCTTCCGGCTCGCGCCTTTTAAGCATCTCCTTTC
CGCCTGCCCGGGCCTTTCTCTACGCACAACAGACAGACGGGATTTCCAGCTGGGGATGGGCCTGACAGGCCCTGAGGGCA
AACAGCATCACATTGACGCGATTGGGCCCGCGCATTTTCTTGCCCTTGCGGGGAGCGTGGGGTTCAGTCAGGCAGCGATG
CGGCAGATACTGGCGGCCTTTATTCCGGGCTTGCCTGCCGCGATTATTAAGGTGCGGGACAGCCTGCCCGATGATTATCC
CCTGACGCTCGCCGATGCGGTTTTCAGCCACGCAATGATGATGCTGGAAAGGGTGCGCCAGGCGACCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8773.03 Da        Isoelectric Point: 7.2012

>AT79027 WP_014605801.1 NZ_CP022427:1776749-1776988 [Pantoea ananatis]
MIYSPRQLANQVRLLRQQNGWTQVELAKKVGLKQATLSHFENAPDTTSLATLFKILQALDLALLLHENSASSAPAEDAW

Download         Length: 240 bp

>AT79027 NZ_CP022427:1776749-1776988 [Pantoea ananatis]
ATGATTTACAGTCCCCGCCAGTTGGCAAATCAGGTCAGGCTACTGCGGCAGCAAAACGGCTGGACCCAGGTCGAACTGGC
GAAAAAAGTGGGCCTGAAACAGGCAACCCTGTCTCACTTCGAAAATGCCCCGGATACAACCTCACTGGCAACGTTGTTCA
AAATCTTACAGGCGCTCGATCTTGCTCTGTTGCTTCATGAAAACAGCGCATCCTCAGCCCCGGCTGAGGATGCCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References