Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 428693..429285 Replicon chromosome
Accession NZ_CP022423
Organism Vitreoscilla filiformis strain ATCC 15551

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag VITFI_RS01965 Protein ID WP_089415580.1
Coordinates 428693..428878 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag VITFI_RS01970 Protein ID WP_089415581.1
Coordinates 428890..429285 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VITFI_RS01950 423854..424705 + 852 WP_198301575.1 MoxR family ATPase -
VITFI_RS01955 424737..425912 + 1176 WP_089415578.1 VWA domain-containing protein -
VITFI_RS01960 425928..427811 + 1884 WP_089415579.1 CRISPR-associated endonuclease Cas3'' -
VITFI_RS01965 428693..428878 + 186 WP_089415580.1 type II toxin-antitoxin system HicA family toxin Toxin
VITFI_RS01970 428890..429285 + 396 WP_089415581.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
VITFI_RS01975 429317..431119 + 1803 WP_157725523.1 type I-E CRISPR-associated protein Cse1/CasA -
VITFI_RS01980 431145..431720 + 576 WP_157725524.1 type I-E CRISPR-associated protein Cse2/CasB -
VITFI_RS01985 431752..432822 + 1071 WP_089415584.1 type I-E CRISPR-associated protein Cas7/Cse4/CasC -
VITFI_RS01990 432828..433637 + 810 WP_157725525.1 type I-E CRISPR-associated protein Cas5/CasD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-125)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 7019.07 Da        Isoelectric Point: 10.7495

>T79007 WP_089415580.1 NZ_CP022423:428693-428878 [Vitreoscilla filiformis]
MNSKQVIKRLEADGWYLARVKGSHHQFKHPNKPGLVTVKHPDGDIPTPTLYSIERQAGWRK

Download         Length: 186 bp

>T79007 NZ_CP022423:428693-428878 [Vitreoscilla filiformis]
ATGAACAGCAAACAGGTCATCAAACGACTGGAGGCGGATGGTTGGTATCTGGCTCGTGTGAAGGGTTCACATCACCAGTT
CAAGCATCCGAACAAACCCGGGTTAGTCACGGTCAAACACCCGGACGGAGACATCCCCACCCCGACCCTCTACAGCATTG
AACGGCAAGCCGGTTGGCGAAAGTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14134.00 Da        Isoelectric Point: 5.1167

>AT79007 WP_089415581.1 NZ_CP022423:428890-429285 [Vitreoscilla filiformis]
MKFTVVLHTDDGQHYGVIVPDLPGCFSGGHGIDDALASVQEAIDLHVETLLDDGVDIPPRQPITVHQANPDYAGGVWAVV
DVPIEKYLGPAEKVNITIPRRLLARIDEYARAHGATRSGFLAEAARQAMRG

Download         Length: 396 bp

>AT79007 NZ_CP022423:428890-429285 [Vitreoscilla filiformis]
ATGAAATTCACCGTGGTTTTGCACACCGATGACGGTCAGCATTACGGCGTCATCGTCCCGGATTTGCCGGGGTGTTTTTC
GGGCGGCCATGGCATTGACGACGCTCTTGCGAGTGTTCAAGAGGCCATTGACCTGCACGTTGAAACACTGCTCGACGATG
GCGTAGACATTCCGCCACGCCAACCCATCACCGTCCACCAAGCCAATCCCGACTACGCCGGGGGGGTGTGGGCGGTGGTG
GACGTACCGATCGAGAAGTACTTGGGGCCTGCCGAAAAAGTCAACATCACCATTCCGCGCCGTTTGCTGGCACGCATTGA
CGAATACGCCCGGGCGCATGGTGCCACCCGCAGCGGTTTTCTGGCAGAAGCTGCACGGCAAGCCATGCGCGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References