Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 174698..176271 Replicon plasmid pSMR1-2
Accession NZ_CP022417
Organism Sulfitobacter pseudonitzschiae strain SMR1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag SULPSESMR1_RS20365 Protein ID WP_089422465.1
Coordinates 174949..176271 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag SULPSESMR1_RS20360 Protein ID WP_089422464.1
Coordinates 174698..174949 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SULPSESMR1_RS20345 171230..172168 + 939 WP_089422884.1 TniB family NTP-binding protein -
SULPSESMR1_RS20350 172165..173223 + 1059 WP_089422885.1 TniQ family protein -
SULPSESMR1_RS20355 173543..174520 + 978 WP_089422463.1 serine hydrolase -
SULPSESMR1_RS20360 174698..174949 + 252 WP_089422464.1 helix-turn-helix domain-containing protein Antitoxin
SULPSESMR1_RS20365 174949..176271 + 1323 WP_089422465.1 type II toxin-antitoxin system HipA family toxin Toxin
SULPSESMR1_RS25080 176485..176574 - 90 Protein_151 transposase -
SULPSESMR1_RS20375 177133..177369 - 237 WP_089422887.1 tyrosine-type recombinase/integrase -
SULPSESMR1_RS20380 177438..178028 + 591 WP_089422888.1 toxin-antitoxin system HicB family antitoxin -
SULPSESMR1_RS20385 178021..179208 + 1188 WP_089422889.1 relaxase/mobilization nuclease domain-containing protein -
SULPSESMR1_RS25085 179238..179375 - 138 WP_157729068.1 hypothetical protein -
SULPSESMR1_RS20390 179430..180479 - 1050 WP_089422890.1 permease -
SULPSESMR1_RS20395 180535..180852 - 318 WP_089422891.1 metalloregulator ArsR/SmtB family transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..292917 292917


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(155-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-66)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 48224.95 Da        Isoelectric Point: 6.9724

>T79003 WP_089422465.1 NZ_CP022417:174949-176271 [Sulfitobacter pseudonitzschiae]
MGRLPAHAPLRVYLNNRRVGTLIREANGAIAFKYDDDWLRWAHSFPISLSLPLRETSYRGEPVSVVFENLLPDSDRLRRL
VAERVGARGTDAYSMLSKIGHDCVGALQFVAGDGDAPDASGEITGEAVDADAIERILQGLGRAPLGLAPDDAFRISIAGA
QEKTALLLKDGQWFKPHGTTPTTHIIKTQIGELPGGIDLSDSVENEYYCLKLVAAFGLATNEARIETFGRTKALVIERFD
RRWTKTGRLLRLPQEDICQARSVPPTLKYQNEGGPGMVDVLNLLEGSDTPGADQETFLKAQVIFWLIGATDGHAKNFSVF
LSPGGSYRMTPLYDILTAQPALNAGLVRRSQMKMAMSAGDNRHYRFDQIHGRHFVQTAMRAGLSRKRAMQIIETVAERAQ
SALDVTAATLPTGFPEALVASVDDAVIQRLRALDMTAERT

Download         Length: 1323 bp

>T79003 NZ_CP022417:174949-176271 [Sulfitobacter pseudonitzschiae]
ATGGGGCGCCTACCGGCCCATGCACCTCTTCGCGTGTACCTGAACAATCGACGGGTCGGGACCCTGATCCGCGAAGCCAA
CGGCGCAATTGCATTCAAATATGACGACGACTGGCTGCGTTGGGCGCACAGCTTTCCGATTTCGCTGTCACTGCCGTTGC
GCGAAACATCCTATAGGGGCGAGCCGGTTTCCGTGGTGTTCGAAAACCTGCTCCCGGATTCCGACAGGCTGCGCCGGCTG
GTTGCAGAGCGGGTAGGGGCCCGTGGCACGGATGCATACAGCATGCTTTCGAAAATCGGGCATGACTGCGTGGGCGCCCT
GCAATTTGTCGCGGGCGATGGCGATGCGCCCGATGCCAGTGGTGAGATCACGGGGGAAGCGGTAGACGCAGACGCCATCG
AAAGGATACTTCAAGGGCTTGGTCGCGCGCCCCTCGGGCTTGCCCCTGATGACGCGTTCCGAATTTCCATCGCCGGAGCC
CAGGAAAAGACAGCGCTTTTGTTGAAGGACGGGCAGTGGTTCAAACCCCATGGCACGACCCCCACGACGCACATCATCAA
GACGCAGATCGGAGAGCTGCCGGGCGGTATTGATCTGTCGGACAGCGTGGAGAACGAATACTACTGCCTGAAACTGGTCG
CGGCATTCGGGTTGGCCACGAACGAGGCCAGGATCGAGACTTTCGGCAGGACAAAGGCGCTTGTCATCGAGCGTTTTGAT
CGCAGGTGGACCAAGACCGGACGCCTGCTGAGGTTGCCGCAAGAGGATATCTGCCAGGCCCGATCCGTGCCGCCGACGCT
TAAATATCAAAACGAGGGCGGGCCAGGGATGGTTGACGTCCTTAACCTGCTTGAAGGCAGCGATACACCGGGCGCGGACC
AGGAGACGTTTTTGAAGGCGCAGGTCATTTTCTGGCTCATCGGAGCAACGGATGGCCATGCAAAGAACTTCAGCGTGTTC
CTGAGCCCCGGAGGCAGCTACCGGATGACGCCGCTTTATGACATACTGACCGCGCAGCCTGCACTGAACGCGGGCCTTGT
CCGGCGCAGCCAGATGAAGATGGCGATGTCCGCAGGCGACAACAGACACTACCGTTTCGATCAGATCCACGGGCGCCATT
TCGTGCAGACGGCCATGCGTGCGGGTCTGTCTAGGAAGCGTGCCATGCAGATCATCGAAACAGTTGCAGAGCGGGCCCAG
TCCGCGCTGGATGTGACCGCCGCGACTCTGCCTACCGGGTTCCCCGAGGCGCTTGTGGCCAGCGTAGACGATGCCGTCAT
CCAGCGGTTGCGCGCGTTGGATATGACAGCCGAGCGCACGTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9226.73 Da        Isoelectric Point: 10.5847

>AT79003 WP_089422464.1 NZ_CP022417:174698-174949 [Sulfitobacter pseudonitzschiae]
MDELARTSRQLGNIILRERKKRGWTQAMLAERAGLRQATVSTIEIGETSSKLPSILAVMAALDLELRVGLRTKGSDKTIE
DIF

Download         Length: 252 bp

>AT79003 NZ_CP022417:174698-174949 [Sulfitobacter pseudonitzschiae]
ATGGATGAACTGGCACGCACATCACGGCAACTTGGGAACATCATCTTGCGCGAACGCAAGAAGCGTGGCTGGACGCAGGC
GATGCTGGCCGAGCGGGCAGGGCTGAGGCAGGCGACAGTCTCCACAATCGAGATCGGAGAGACCTCGTCAAAGCTGCCAT
CCATCCTTGCTGTCATGGCGGCATTGGATCTGGAATTGAGGGTTGGTCTGCGCACGAAAGGCAGCGACAAGACCATCGAG
GACATCTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References