Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 83060..84633 Replicon plasmid pSMR1-1
Accession NZ_CP022416
Organism Sulfitobacter pseudonitzschiae strain SMR1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag SULPSESMR1_RS17975 Protein ID WP_089422465.1
Coordinates 83311..84633 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag SULPSESMR1_RS17970 Protein ID WP_089422464.1
Coordinates 83060..83311 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SULPSESMR1_RS17955 79203..79559 - 357 WP_089422461.1 hypothetical protein -
SULPSESMR1_RS17960 79667..81613 + 1947 WP_089422462.1 cache domain-containing protein -
SULPSESMR1_RS17965 81905..82882 + 978 WP_089422463.1 serine hydrolase -
SULPSESMR1_RS17970 83060..83311 + 252 WP_089422464.1 helix-turn-helix domain-containing protein Antitoxin
SULPSESMR1_RS17975 83311..84633 + 1323 WP_089422465.1 type II toxin-antitoxin system HipA family toxin Toxin
SULPSESMR1_RS17980 84928..85197 - 270 WP_089422466.1 hypothetical protein -
SULPSESMR1_RS17985 85194..86765 - 1572 WP_089422467.1 IS66 family transposase -
SULPSESMR1_RS17990 86834..87187 - 354 WP_089422468.1 IS66 family insertion sequence element accessory protein TnpB -
SULPSESMR1_RS17995 87184..87615 - 432 WP_089422469.1 transposase -
SULPSESMR1_RS18005 88029..88370 + 342 WP_089422470.1 DUF2853 family protein -
SULPSESMR1_RS18010 88439..88735 + 297 WP_089422471.1 hypothetical protein -
SULPSESMR1_RS18015 88827..89384 - 558 Protein_87 IS6 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - gmd / fcl 1..428095 428095


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(155-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-66)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 48224.95 Da        Isoelectric Point: 6.9724

>T79002 WP_089422465.1 NZ_CP022416:83311-84633 [Sulfitobacter pseudonitzschiae]
MGRLPAHAPLRVYLNNRRVGTLIREANGAIAFKYDDDWLRWAHSFPISLSLPLRETSYRGEPVSVVFENLLPDSDRLRRL
VAERVGARGTDAYSMLSKIGHDCVGALQFVAGDGDAPDASGEITGEAVDADAIERILQGLGRAPLGLAPDDAFRISIAGA
QEKTALLLKDGQWFKPHGTTPTTHIIKTQIGELPGGIDLSDSVENEYYCLKLVAAFGLATNEARIETFGRTKALVIERFD
RRWTKTGRLLRLPQEDICQARSVPPTLKYQNEGGPGMVDVLNLLEGSDTPGADQETFLKAQVIFWLIGATDGHAKNFSVF
LSPGGSYRMTPLYDILTAQPALNAGLVRRSQMKMAMSAGDNRHYRFDQIHGRHFVQTAMRAGLSRKRAMQIIETVAERAQ
SALDVTAATLPTGFPEALVASVDDAVIQRLRALDMTAERT

Download         Length: 1323 bp

>T79002 NZ_CP022416:83311-84633 [Sulfitobacter pseudonitzschiae]
ATGGGGCGCCTACCGGCCCATGCACCTCTTCGCGTGTACCTGAACAATCGACGGGTCGGGACCCTGATCCGCGAAGCCAA
CGGCGCAATTGCATTCAAATATGACGACGACTGGCTGCGTTGGGCGCACAGCTTTCCGATTTCGCTGTCACTGCCGTTGC
GCGAAACATCCTATAGGGGCGAGCCGGTTTCCGTGGTGTTCGAAAACCTGCTCCCGGATTCCGACAGGCTGCGCCGGCTG
GTTGCAGAGCGGGTAGGGGCCCGTGGCACGGATGCATACAGCATGCTTTCGAAAATCGGGCATGACTGCGTGGGCGCCCT
GCAATTTGTCGCGGGCGATGGCGATGCGCCCGATGCCAGTGGTGAGATCACGGGGGAAGCGGTAGACGCAGACGCCATCG
AAAGGATACTTCAAGGGCTTGGTCGCGCGCCCCTCGGGCTTGCCCCTGATGACGCGTTCCGAATTTCCATCGCCGGAGCC
CAGGAAAAGACAGCGCTTTTGTTGAAGGACGGGCAGTGGTTCAAACCCCATGGCACGACCCCCACGACGCACATCATCAA
GACGCAGATCGGAGAGCTGCCGGGCGGTATTGATCTGTCGGACAGCGTGGAGAACGAATACTACTGCCTGAAACTGGTCG
CGGCATTCGGGTTGGCCACGAACGAGGCCAGGATCGAGACTTTCGGCAGGACAAAGGCGCTTGTCATCGAGCGTTTTGAT
CGCAGGTGGACCAAGACCGGACGCCTGCTGAGGTTGCCGCAAGAGGATATCTGCCAGGCCCGATCCGTGCCGCCGACGCT
TAAATATCAAAACGAGGGCGGGCCAGGGATGGTTGACGTCCTTAACCTGCTTGAAGGCAGCGATACACCGGGCGCGGACC
AGGAGACGTTTTTGAAGGCGCAGGTCATTTTCTGGCTCATCGGAGCAACGGATGGCCATGCAAAGAACTTCAGCGTGTTC
CTGAGCCCCGGAGGCAGCTACCGGATGACGCCGCTTTATGACATACTGACCGCGCAGCCTGCACTGAACGCGGGCCTTGT
CCGGCGCAGCCAGATGAAGATGGCGATGTCCGCAGGCGACAACAGACACTACCGTTTCGATCAGATCCACGGGCGCCATT
TCGTGCAGACGGCCATGCGTGCGGGCCTGTCTAGGAAGCGTGCCATGCAGATCATCGAAACAGTTGCAGAGCGGGCCCAG
TCCGCGCTGGATGTGACCGCCGCGACCCTGCCTACCGGGTTCCCCGAGGCGCTTGTGGCCAGCGTAGACGATGCCGTCAT
CCAGCGGTTGCGCGCGTTGGATATGACAGCCGAGCGCACGTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9226.73 Da        Isoelectric Point: 10.5847

>AT79002 WP_089422464.1 NZ_CP022416:83060-83311 [Sulfitobacter pseudonitzschiae]
MDELARTSRQLGNIILRERKKRGWTQAMLAERAGLRQATVSTIEIGETSSKLPSILAVMAALDLELRVGLRTKGSDKTIE
DIF

Download         Length: 252 bp

>AT79002 NZ_CP022416:83060-83311 [Sulfitobacter pseudonitzschiae]
ATGGATGAACTGGCACGCACATCACGGCAACTTGGGAACATCATCTTGCGCGAACGCAAGAAGCGTGGCTGGACGCAGGC
GATGCTGGCCGAGCGGGCAGGGCTGAGGCAGGCGACAGTCTCCACAATCGAGATCGGAGAGACCTCGTCAAAGCTGCCAT
CCATCCTTGCTGTCATGGCGGCATTGGATCTGGAATTGAGGGTTGGTCTGCGCACGAAAGGCAGCGACAAGACCATCGAG
GACATCTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References