Detailed information of TA system TA079001

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 876623..877173
• Replicon: chromosome
• Accession: NZ_CP022413
• Organism: Blautia hansenii DSM 20583

Toxin (Protein)

• Gene name: relE
• Uniprot ID: C9LBU6
• Locus tag: CGC63_RS04450
• Protein ID: WP_004223437.1
• Coordinates: 876892..877173 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: C9LBU7
• Locus tag: CGC63_RS04445
• Protein ID: WP_004223440.1
• Coordinates: 876623..876895 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CGC63_RS04425	871955..873475	+	1521	WP_009246857.1	ABC transporter ATP-binding protein	-
CGC63_RS04430	873477..874565	+	1089	WP_040351279.1	ABC transporter permease	-
CGC63_RS04435	874565..875512	+	948	WP_089438666.1	ABC transporter permease	-
CGC63_RS04440	875521..876480	+	960	WP_004223441.1	biotin--[acetyl-CoA-carboxylase] ligase	-
CGC63_RS04445	876623..876895	+	273	WP_004223440.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
CGC63_RS04450	876892..877173	+	282	WP_004223437.1	type II toxin-antitoxin system YafQ family toxin	Toxin
CGC63_RS04455	877239..877733	-	495	WP_004223436.1	VanZ family protein	-
CGC63_RS04460	877877..878728	+	852	WP_004223433.1	thymidylate synthase	-
CGC63_RS04465	878742..879230	+	489	WP_004223430.1	dihydrofolate reductase	-
CGC63_RS04470	879381..880214	-	834	WP_004223427.1	LarC family nickel insertion protein	-
CGC63_RS04475	880233..881267	-	1035	WP_004223424.1	LacI family DNA-binding transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (6-92)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (6-78)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10925.81 Da
• Isoelectric Point: 7.2752

>T79001 WP_004223437.1 NZ_CP022413:876892-877173 [Blautia hansenii DSM 20583]
MMYDLILTGKFKKSLKLAKKRGLNISLLEEVVNILQSGEELDKKYRDHELKGKYKNFRECHIQPDWLLIYLIENDILTLT
LVDTGTHADLFNM

Nucleotide

• Length: 282 bp

>T79001 NZ_CP022413:876892-877173 [Blautia hansenii DSM 20583]
ATGATGTATGATTTAATTTTAACGGGAAAGTTTAAAAAGAGTTTAAAGCTCGCCAAAAAAAGAGGACTAAATATTAGTTT
ATTAGAAGAAGTAGTAAATATACTTCAAAGTGGAGAAGAACTTGATAAAAAATATCGTGACCATGAGTTGAAAGGAAAAT
ATAAAAATTTTCGTGAATGTCATATACAACCAGATTGGCTGCTTATTTATCTGATCGAGAATGATATTTTGACGCTTACA
TTAGTTGATACGGGAACACATGCGGATTTGTTTAATATGTAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 9965.38 Da
• Isoelectric Point: 4.5358

>AT79001 WP_004223440.1 NZ_CP022413:876623-876895 [Blautia hansenii DSM 20583]
MKNVTTSIRIDSNTKQAATELLNELGLDLSSAVNIFLKQVVLQGGLPFQVKYPQYKPEVLAAMEEAEALSKNPNTKKYSS
FSEALEDMDI

Nucleotide

• Length: 273 bp

>AT79001 NZ_CP022413:876623-876895 [Blautia hansenii DSM 20583]
ATGAAAAATGTTACAACCAGCATCCGAATAGATAGTAATACAAAACAGGCAGCAACAGAGCTATTAAATGAGTTAGGACT
TGACTTGAGCAGTGCAGTAAATATTTTTTTGAAACAGGTTGTCCTGCAAGGAGGATTACCATTTCAAGTAAAATATCCTC
AATATAAACCAGAAGTGCTTGCAGCTATGGAAGAAGCAGAAGCTTTGAGCAAAAATCCAAATACAAAAAAATATTCAAGT
TTCTCTGAAGCATTAGAGGATATGGATATATGA

Structures

Toxin

• AlphaFold DB: C9LBU6

Antitoxin

• AlphaFold DB: C9LBU7