Detailed information of TA system TA078999

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 2921565..2922084
• Replicon: chromosome
• Accession: NZ_CP022411
• Organism: Pseudomonas sp. RU47

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CCX46_RS13240
• Protein ID: WP_127927109.1
• Coordinates: 2921803..2922084 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A4R7V066
• Locus tag: CCX46_RS13235
• Protein ID: WP_038368375.1
• Coordinates: 2921565..2921813 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCX46_RS13225	2916615..2919251	+	2637	WP_127927105.1	hypothetical protein	-
CCX46_RS13230	2919710..2921269	+	1560	WP_127927107.1	TerC family protein	-
CCX46_RS13235	2921565..2921813	+	249	WP_038368375.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CCX46_RS13240	2921803..2922084	+	282	WP_127927109.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CCX46_RS13245	2922126..2922593	-	468	WP_127927111.1	hypothetical protein	-
CCX46_RS13250	2922650..2923081	-	432	WP_127927113.1	thioredoxin family protein	-
CCX46_RS13255	2923250..2923576	-	327	WP_127927115.1	hypothetical protein	-
CCX46_RS13260	2924001..2924849	+	849	WP_064117896.1	transporter substrate-binding domain-containing protein	-
CCX46_RS13265	2924901..2925563	+	663	WP_038368362.1	amino acid ABC transporter permease	-
CCX46_RS13270	2925573..2926235	+	663	WP_127927117.1	amino acid ABC transporter permease	-
CCX46_RS13275	2926232..2927023	+	792	WP_127927119.1	amino acid ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2906945..2922593	15648

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10723.58 Da
• Isoelectric Point: 10.5377

>T78999 WP_127927109.1 NZ_CP022411:2921803-2922084 [Pseudomonas sp. RU47]
MTYELEFSEKAWKEWEKLGAGLRDQFKKKLAERLLNPHVPADRLKGLGNAYKIKLRSAGYRMVYRVKDEVLVVAVIAVGK
RARGEIYTEAAKR

Nucleotide

• Length: 282 bp

>T78999 NZ_CP022411:2921803-2922084 [Pseudomonas sp. RU47]
ATGACCTATGAGCTGGAATTTTCTGAAAAGGCCTGGAAAGAGTGGGAGAAGCTGGGCGCAGGTCTACGAGATCAGTTCAA
GAAAAAACTAGCGGAGCGGCTGCTTAATCCACATGTACCGGCGGATCGACTCAAAGGCCTCGGTAATGCATACAAAATTA
AGCTGCGGAGCGCCGGATATCGGATGGTGTATCGGGTCAAGGATGAAGTATTGGTGGTCGCGGTGATAGCCGTTGGCAAG
CGAGCGCGAGGCGAAATCTATACAGAGGCTGCCAAGCGCTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8971.41 Da
• Isoelectric Point: 5.0492

>AT78999 WP_038368375.1 NZ_CP022411:2921565-2921813 [Pseudomonas sp. RU47]
MAHIVLSHVVASISELKKNPMGTVAAGGGRSVAILNRNEPAFYCVPAKEYEAMMTRLDDLELIALCKERENDPTIKVSID
DL

Nucleotide

• Length: 249 bp

>AT78999 NZ_CP022411:2921565-2921813 [Pseudomonas sp. RU47]
ATGGCACACATCGTTCTTTCTCACGTAGTAGCGAGTATTTCCGAATTGAAAAAAAATCCGATGGGCACTGTAGCTGCTGG
AGGTGGACGCTCTGTAGCGATTCTCAACCGAAATGAACCAGCGTTTTATTGCGTACCTGCCAAAGAATACGAGGCAATGA
TGACGCGCCTTGATGATCTGGAGTTGATCGCGCTTTGCAAGGAGCGAGAAAACGACCCCACCATCAAGGTCTCAATAGAT
GACCTATGA

Structures

Antitoxin

• AlphaFold DB: A0A4R7V066