Detailed information of TA system TA078996

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1818369..1818988
• Replicon: chromosome
• Accession: NZ_CP022411
• Organism: Pseudomonas sp. RU47

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: CCX46_RS08285
• Protein ID: WP_127926334.1
• Coordinates: 1818369..1818584 (+)
• Length: 72 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: CCX46_RS08290
• Protein ID: WP_123374656.1
• Coordinates: 1818584..1818988 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCX46_RS08260	1813547..1815535	+	1989	WP_127926331.1	heme lyase CcmF/NrfE family subunit	-
CCX46_RS08265	1815532..1816068	+	537	WP_007919961.1	DsbE family thiol:disulfide interchange protein	-
CCX46_RS08270	1816065..1816535	+	471	WP_127926332.1	cytochrome c-type biogenesis protein CcmH	-
CCX46_RS08275	1816532..1817734	+	1203	WP_127926333.1	c-type cytochrome biogenesis protein CcmI	-
CCX46_RS08280	1817760..1818164	+	405	WP_016987493.1	hypothetical protein	-
CCX46_RS08285	1818369..1818584	+	216	WP_127926334.1	type II toxin-antitoxin system HicA family toxin	Toxin
CCX46_RS08290	1818584..1818988	+	405	WP_123374656.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
CCX46_RS08295	1819058..1820245	-	1188	WP_127926335.1	MFS transporter	-
CCX46_RS08300	1820490..1821110	+	621	WP_127926336.1	hypothetical protein	-
CCX46_RS08305	1821350..1822348	-	999	WP_034151535.1	sulfate ABC transporter substrate-binding protein	-
CCX46_RS08310	1822453..1823277	-	825	WP_038363916.1	ion transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 72 a.a.
• Molecular weight: 8105.28 Da
• Isoelectric Point: 10.0381

>T78996 WP_127926334.1 NZ_CP022411:1818369-1818584 [Pseudomonas sp. RU47]
MVQSRQLIKELEEAGWALDRITGSHHIFTHRYNPYTIPVPHPKKDLPLGTVKSIRRRAGLYNPPASFEGDP

Nucleotide

• Length: 216 bp

>T78996 NZ_CP022411:1818369-1818584 [Pseudomonas sp. RU47]
TTGGTACAAAGCAGGCAATTGATCAAGGAGCTGGAGGAGGCTGGCTGGGCGCTGGATCGGATCACCGGCAGTCATCACAT
CTTCACTCACCGATACAACCCGTACACGATTCCCGTCCCTCACCCGAAAAAGGATTTGCCGCTGGGGACGGTCAAAAGCA
TCAGGAGGCGTGCCGGGTTGTACAACCCGCCAGCCAGTTTCGAAGGAGATCCATAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14803.78 Da
• Isoelectric Point: 4.3945

>AT78996 WP_123374656.1 NZ_CP022411:1818584-1818988 [Pseudomonas sp. RU47]
MQYPICIEWGDENTAIGIQIPDIPGAVTAGDSFEDAYKAAVEVAHIMLQEIAADGESIPMPTSASAHRSNPEFADMGWGM
LELDISPYLGKTEKVNVTLPGYVIQRIDRYVREHNVKSRSSFLADAAMEKLVRY

Nucleotide

• Length: 405 bp

>AT78996 NZ_CP022411:1818584-1818988 [Pseudomonas sp. RU47]
ATGCAATATCCAATCTGCATCGAGTGGGGTGACGAAAATACCGCCATCGGTATTCAGATCCCCGATATTCCCGGCGCCGT
TACAGCAGGGGATAGCTTTGAAGATGCCTACAAGGCGGCGGTTGAAGTCGCCCACATCATGCTGCAGGAGATTGCGGCGG
ACGGGGAGTCGATTCCTATGCCGACTTCGGCATCCGCTCATCGCAGTAATCCCGAATTTGCCGATATGGGCTGGGGCATG
CTTGAGTTGGACATTTCGCCCTATCTCGGCAAGACCGAGAAGGTCAACGTAACGCTGCCCGGTTACGTGATTCAGCGCAT
CGATCGTTATGTGCGCGAGCACAACGTCAAAAGCCGCTCCTCCTTTCTGGCGGATGCGGCGATGGAAAAACTGGTTCGTT
ATTAA