Detailed information of TA system TA078992

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 273637..274280
• Replicon: chromosome
• Accession: NZ_CP022411
• Organism: Pseudomonas sp. RU47

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A4R7VCK5
• Locus tag: CCX46_RS01205
• Protein ID: WP_026000492.1
• Coordinates: 273637..273819 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: CCX46_RS01210
• Protein ID: WP_174245096.1
• Coordinates: 273849..274280 (+)
• Length: 144 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCX46_RS01190	269675..270601	+	927	WP_016983653.1	serine acetyltransferase	-
CCX46_RS01195	271003..272964	+	1962	WP_174245095.1	choline transporter BetT	-
CCX46_RS01200	272988..273248	-	261	WP_127925434.1	hypothetical protein	-
CCX46_RS01205	273637..273819	+	183	WP_026000492.1	type II toxin-antitoxin system HicA family toxin	Toxin
CCX46_RS01210	273849..274280	+	432	WP_174245096.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
CCX46_RS01215	274286..275323	-	1038	WP_127925435.1	LacI family DNA-binding transcriptional regulator	-
CCX46_RS01220	275529..277754	+	2226	WP_127925436.1	TonB-dependent receptor	-
CCX46_RS01225	277756..279075	+	1320	WP_127925437.1	LLM class flavin-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (13-137)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6903.02 Da
• Isoelectric Point: 10.5417

>T78992 WP_026000492.1 NZ_CP022411:273637-273819 [Pseudomonas sp. RU47]
MRSREMIRMIEDDGWYLVAVKGSHHQYKHPHKPGRVTIKHPDSDLPKGTINSILKQAGLK

Nucleotide

• Length: 183 bp

>T78992 NZ_CP022411:273637-273819 [Pseudomonas sp. RU47]
ATGCGCAGTCGGGAAATGATCAGGATGATCGAAGACGATGGTTGGTATCTCGTGGCGGTGAAAGGCAGCCACCACCAATA
CAAGCATCCGCACAAGCCAGGAAGGGTGACGATCAAGCACCCTGATTCGGATCTGCCCAAGGGCACGATCAACAGCATTT
TGAAACAGGCGGGCTTGAAATGA

Antitoxin

Protein

• Length: 144 a.a.
• Molecular weight: 15723.63 Da
• Isoelectric Point: 4.4225

>AT78992 WP_174245096.1 NZ_CP022411:273849-274280 [Pseudomonas sp. RU47]
MGLSEEGLTHMKFPVVLHKDADSDYGVIIPDVPGCFSAGTTVAEAFENTQEALALHYEGLVADSAPLPQVRDIDAHLDNP
DYAGGIWGVVDFDITPYFGKSVRFNATLPEQLLERIDQTVRRDQRYRSRSGFLAAAALRELSV

Nucleotide

• Length: 432 bp

>AT78992 NZ_CP022411:273849-274280 [Pseudomonas sp. RU47]
ATGGGCCTGTCAGAGGAAGGACTCACTCATATGAAATTCCCGGTCGTTCTGCACAAGGATGCCGACTCAGACTACGGAGT
GATCATCCCGGATGTCCCGGGTTGTTTCTCCGCAGGCACTACGGTCGCTGAGGCGTTTGAAAATACTCAGGAGGCATTGG
CGCTTCACTATGAGGGGTTGGTAGCCGACAGCGCGCCGTTACCGCAAGTGCGGGACATTGATGCTCATCTCGATAACCCG
GATTACGCGGGAGGGATCTGGGGCGTGGTCGATTTTGATATCACCCCGTATTTCGGCAAGTCAGTGCGTTTTAACGCCAC
GCTGCCGGAGCAGTTGCTTGAGCGTATTGACCAGACAGTCCGCCGTGACCAGCGCTATCGATCCCGTTCCGGATTTCTCG
CGGCGGCCGCCTTGCGCGAACTGTCGGTATAG

Structures

Toxin

• AlphaFold DB: A0A4R7VCK5