Detailed information of TA system TA078991

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 574966..575590
• Replicon: chromosome
• Accession: NZ_CP022409
• Organism: Helicobacter pylori strain G272

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CGC32_RS02900
• Protein ID: WP_089482459.1
• Coordinates: 575324..575590 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: CGC32_RS02895
• Protein ID: WP_089482458.1
• Coordinates: 574966..575343 (+)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CGC32_RS02865	570652..571173	-	522	WP_089482455.1	hypothetical protein	-
CGC32_RS02885	571798..574023	+	2226	WP_089482456.1	Hop family adhesin BabA	-
CGC32_RS02895	574966..575343	+	378	WP_089482458.1	hypothetical protein	Antitoxin
CGC32_RS02900	575324..575590	+	267	WP_089482459.1	type II toxin-antitoxin system YafQ family toxin	Toxin
CGC32_RS02905	575699..576223	-	525	WP_089482460.1	acyl-CoA thioesterase	-
CGC32_RS02910	576363..577211	+	849	WP_089482461.1	SDR family oxidoreductase	-
CGC32_RS02915	577204..578184	+	981	WP_015644926.1	iron ABC transporter permease	-
CGC32_RS02920	578184..578951	+	768	WP_075653295.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10333.20 Da
• Isoelectric Point: 9.6292

>T78991 WP_089482459.1 NZ_CP022409:575324-575590 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSILNKVILSLRKKEPLDPQFQDHALKGKWKPFRECHIKSDILLVYLVKDDELILVR
LGSHSELF

Nucleotide

• Length: 267 bp

>T78991 NZ_CP022409:575324-575590 [Helicobacter pylori]
GTGTTAAAACTCAATCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTACTTTTGAATGGGTTTGATGATAGTATTTT
GAATAAGGTCATTCTGTCTTTGAGAAAGAAAGAACCGCTAGACCCACAATTTCAAGATCATGCTTTGAAAGGAAAGTGGA
AGCCTTTTAGGGAATGCCACATCAAATCTGATATTTTGCTTGTGTATTTGGTGAAAGATGATGAGCTTATTTTAGTAAGG
TTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 14713.68 Da
• Isoelectric Point: 7.8106

>AT78991 WP_089482458.1 NZ_CP022409:574966-575343 [Helicobacter pylori]
MPNTTAKKDYTQYSEKQLFNLIHQLEQKIKKMQNDRVSFKEKMAKELDKRDQNFKDKIDALNELLQKISQAFDNKRDCCL
GYEIPNIETQQAMRDALNKETDLIVEDFSSYSDERKKALGVKTQS

Nucleotide

• Length: 378 bp

>AT78991 NZ_CP022409:574966-575343 [Helicobacter pylori]
ATGCCTAACACCACCGCCAAAAAAGACTACACCCAATACAGCGAAAAACAGCTTTTTAACTTAATCCATCAATTAGAGCA
AAAGATCAAAAAGATGCAAAATGATAGAGTTTCTTTTAAAGAAAAAATGGCTAAAGAATTAGACAAAAGGGATCAAAACT
TTAAGGATAAAATAGATGCATTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATAATAAAAGAGATTGTTGTTTG
GGGTATGAGATCCCAAACATTGAAACGCAACAAGCCATGAGAGATGCGTTAAACAAAGAAACCGATTTGATTGTTGAGGA
TTTCTCTAGTTATAGCGATGAAAGAAAAAAGGCGTTAGGTGTTAAAACTCAATCTTAA