Detailed information of TA system TA078978

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 3399282..3400270
• Replicon: chromosome
• Accession: NZ_CP022407
• Organism: Escherichia coli O121:H19 strain 16-9255

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: CGC46_RS18235
• Protein ID: WP_014640052.1
• Coordinates: 3399282..3399668 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: A0A0A1AFM1
• Locus tag: CGC46_RS18240
• Protein ID: WP_000458583.1
• Coordinates: 3399698..3400270 (-)
• Length: 191 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CGC46_RS18195	3395441..3395776	+	336	WP_000543621.1	hypothetical protein	-
CGC46_RS18200	3395767..3396117	+	351	WP_001242740.1	hypothetical protein	-
CGC46_RS18205	3396114..3396587	+	474	WP_000145671.1	class I SAM-dependent methyltransferase	-
CGC46_RS18210	3396734..3397201	+	468	WP_000829413.1	hypothetical protein	-
CGC46_RS18215	3397203..3397394	+	192	WP_001014294.1	hypothetical protein	-
CGC46_RS18220	3397397..3398131	+	735	WP_001094871.1	DUF551 domain-containing protein	-
CGC46_RS18225	3398131..3398703	+	573	WP_001061339.1	3'-5' exoribonuclease	-
CGC46_RS18230	3398740..3399021	+	282	WP_001093921.1	pyocin activator PrtN family protein	-
CGC46_RS29950	3399069..3399242	-	174	WP_000390069.1	hypothetical protein	-
CGC46_RS18235	3399282..3399668	-	387	WP_014640052.1	hypothetical protein	Toxin
CGC46_RS18240	3399698..3400270	-	573	WP_000458583.1	SocA family protein	Antitoxin
CGC46_RS18245	3400505..3400627	-	123	WP_001300034.1	hypothetical protein	-
CGC46_RS18250	3400990..3401976	-	987	WP_000912572.1	DUF2713 domain-containing protein	-
CGC46_RS18255	3402294..3402809	+	516	WP_001295691.1	zinc uptake transcriptional repressor Zur	-
CGC46_RS18260	3402851..3403060	-	210	WP_001030593.1	CsbD family protein	-
CGC46_RS18265	3403176..3404501	-	1326	WP_001370252.1	MATE family efflux transporter DinF	-
CGC46_RS18270	3404574..3405182	-	609	WP_000646078.1	transcriptional repressor LexA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	nleG7'	3347376..3405182	57806

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (27-137)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14465.40 Da
• Isoelectric Point: 5.4833

>T78978 WP_014640052.1 NZ_CP022407:c3399668-3399282 [Escherichia coli O121:H19]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Nucleotide

• Length: 387 bp

>T78978 NZ_CP022407:c3399668-3399282 [Escherichia coli O121:H19]
GTGCTTGCCCCAACTGGGCCATGCAATCATCTTCATGTGATTTGTAATGATCCTGTTTATTACCCCGTTAACGATTGTTA
TTGTGTTTTAGTTGTTAATATTTCTAGTATCAAGGATGGGGTCCCCCACGATCCGTCTTGCGTCTTGAATTCCGGTGATC
ATCGCTTTATCAAGCATCCAAGTTATGTTGTTTACGCTGAAGCTATAATTTGGCGAGTGGATAACATGGTTAGAAAGCAG
CGATCGGGTGAGATTTCTGTTCATGATGATATGCCAGAAGCTACATTCAATAGAATTCTGGACGGTTTTGATATATCTGA
TGAAGTTACGCCAAAGAACCTTAAATTTAAAAATAAATATTGCGTATCATCTATTGATGATGAGTAA

Antitoxin

Protein

• Length: 191 a.a.
• Molecular weight: 21956.30 Da
• Isoelectric Point: 6.0283

>AT78978 WP_000458583.1 NZ_CP022407:c3400270-3399698 [Escherichia coli O121:H19]
MFCEEKVAQMAAYLLLKRGGRMAYLKLMKLLYLSNRKSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYN
LIETNGHDVLLRSDPREMDADEVFDELSRADIRILDEIYSLYGHMNRFDLANMTHLESVCPEWHNPGNSRKPIDLKEMLI
SEGKSEDEANRIIGKMEESQKLKEFSLQLS

Nucleotide

• Length: 573 bp

>AT78978 NZ_CP022407:c3400270-3399698 [Escherichia coli O121:H19]
ATGTTTTGCGAAGAAAAAGTAGCTCAAATGGCTGCATACCTACTTCTTAAGCGAGGTGGGCGCATGGCATATCTGAAATT
GATGAAGCTGCTCTATCTGTCTAACCGCAAGTCGATTTTGAAGCATGGCAGGATGATCGGCGAAGATAGCCTTTACTCTA
TGAAATTTGGTCCAGTCATGTCGAATACGCTGAACTTGATTCGTGGTAAGGCTGAAGGCATTGGTGACTACTGGTACAAC
TTGATAGAGACGAACGGGCATGATGTGTTGTTGCGTTCAGATCCGAGGGAAATGGATGCAGACGAGGTCTTTGATGAGTT
GAGCCGTGCAGATATCCGGATTTTAGATGAAATCTATTCTCTGTATGGGCATATGAACCGATTTGATCTCGCAAACATGA
CGCATTTAGAAAGCGTTTGTCCAGAGTGGCACAATCCTGGCAATTCTCGTAAGCCTATAGACCTGAAAGAAATGCTGATC
AGTGAGGGTAAAAGCGAGGATGAGGCTAATCGCATAATTGGCAAAATGGAAGAATCTCAGAAACTTAAGGAATTTTCTTT
GCAATTATCATGA

Structures

Antitoxin

• AlphaFold DB: A0A0A1AFM1