Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1793316..1793794 Replicon chromosome
Accession NZ_CP022407
Organism Escherichia coli O121:H19 strain 16-9255

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag CGC46_RS09950 Protein ID WP_001303876.1
Coordinates 1793507..1793794 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag CGC46_RS09945 Protein ID WP_000536233.1
Coordinates 1793316..1793507 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGC46_RS09910 1788699..1789469 - 771 WP_000450862.1 DUF1627 domain-containing protein -
CGC46_RS09915 1789495..1790235 - 741 WP_000788752.1 ATP-binding protein -
CGC46_RS09920 1790232..1791356 - 1125 WP_072097015.1 DNA-binding protein -
CGC46_RS09925 1791435..1791890 + 456 WP_000273724.1 hypothetical protein -
CGC46_RS09930 1792097..1792522 - 426 WP_000693855.1 Rha family transcriptional regulator -
CGC46_RS09935 1792506..1792778 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
CGC46_RS09940 1792887..1793288 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
CGC46_RS09945 1793316..1793507 + 192 WP_000536233.1 hypothetical protein Antitoxin
CGC46_RS09950 1793507..1793794 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CGC46_RS09955 1794071..1794226 + 156 WP_000379575.1 DUF1391 family protein -
CGC46_RS09965 1794368..1794757 + 390 WP_000394511.1 hypothetical protein -
CGC46_RS09970 1794944..1795129 - 186 WP_001133046.1 hypothetical protein -
CGC46_RS09980 1795703..1795891 + 189 WP_000413705.1 cell division inhibition protein DicB -
CGC46_RS09985 1795888..1796079 + 192 WP_001098307.1 DUF1482 family protein -
CGC46_RS09990 1796173..1798644 + 2472 WP_054626455.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T78973 WP_001303876.1 NZ_CP022407:1793507-1793794 [Escherichia coli O121:H19]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T78973 NZ_CP022407:1793507-1793794 [Escherichia coli O121:H19]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT78973 WP_000536233.1 NZ_CP022407:1793316-1793507 [Escherichia coli O121:H19]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT78973 NZ_CP022407:1793316-1793507 [Escherichia coli O121:H19]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References