Detailed information of TA system TA078933

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): BrnTA/BrnT-BrnA
• Location: 3118386..3118941
• Replicon: chromosome
• Accession: NZ_CP022374
• Organism: Acetobacter oryzifermentans strain dm

Toxin (Protein)

• Gene name: brnT
• Uniprot ID: F1YWD7
• Locus tag: CBI36_RS14925
• Protein ID: WP_006117339.1
• Coordinates: 3118678..3118941 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: brnA
• Uniprot ID: -
• Locus tag: CBI36_RS14920
• Protein ID: WP_081461476.1
• Coordinates: 3118386..3118670 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CBI36_RS14890	3113432..3115024	+	1593	WP_089179849.1	hypothetical protein	-
CBI36_RS14895	3115024..3115833	+	810	WP_089179850.1	hypothetical protein	-
CBI36_RS14900	3115867..3116079	+	213	WP_003628621.1	hypothetical protein	-
CBI36_RS14905	3116666..3117124	+	459	WP_035354359.1	lysozyme	-
CBI36_RS15410	3117167..3117325	+	159	WP_162784330.1	hypothetical protein	-
CBI36_RS14910	3117390..3118082	+	693	WP_006117341.1	hypothetical protein	-
CBI36_RS14915	3118160..3118369	+	210	WP_035354356.1	hypothetical protein	-
CBI36_RS14920	3118386..3118670	-	285	WP_081461476.1	BrnA antitoxin family protein	Antitoxin
CBI36_RS14925	3118678..3118941	-	264	WP_006117339.1	BrnT family toxin	Toxin
CBI36_RS14935	3119377..3119961	-	585	WP_006116589.1	TIGR00730 family Rossman fold protein	-
CBI36_RS14940	3120010..3121242	-	1233	WP_006116590.1	MFS transporter	-
CBI36_RS14945	3121339..3121914	+	576	WP_063354804.1	NUDIX hydrolase	-
CBI36_RS14950	3121948..3122400	-	453	WP_035353112.1	protoporphyrinogen oxidase HemJ	-
CBI36_RS14955	3122403..3123104	-	702	WP_089179851.1	HAD family phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-79)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (19-90)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10074.56 Da
• Isoelectric Point: 9.7308

>T78933 WP_006117339.1 NZ_CP022374:c3118941-3118678 [Acetobacter oryzifermentans]
MRYDWDEAKRQSNIAKHGVDFADAEDFEWDVAFVMTSRSANEPRLVAIAPINLRLHVLVFSIETRIVRIISLRKANKREA
KLYAAQT

Nucleotide

• Length: 264 bp

>T78933 NZ_CP022374:c3118941-3118678 [Acetobacter oryzifermentans]
ATGAGATACGATTGGGACGAAGCAAAGCGTCAAAGTAACATCGCCAAGCATGGCGTTGATTTTGCTGATGCTGAAGACTT
CGAATGGGATGTGGCTTTTGTCATGACAAGTCGTAGCGCAAACGAGCCCCGCCTTGTTGCTATTGCCCCAATCAATCTCC
GCCTGCATGTGCTGGTTTTCAGCATTGAAACACGCATTGTCCGCATCATCAGCCTACGAAAGGCCAACAAACGGGAGGCA
AAGCTTTATGCCGCGCAAACCTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10284.66 Da
• Isoelectric Point: 4.7435

>AT78933 WP_081461476.1 NZ_CP022374:c3118670-3118386 [Acetobacter oryzifermentans]
MPTDEEDALINQGILQDADNPELTDQDFLNAKPASVAVPALAAQRRVRGPQKAPTKKLVSIRLDPDLIDRLKQDGPGWQG
RVNDMLRQAIGLTS

Nucleotide

• Length: 285 bp

>AT78933 NZ_CP022374:c3118670-3118386 [Acetobacter oryzifermentans]
ATGCCTACGGATGAAGAAGATGCCCTGATCAATCAGGGCATCTTGCAAGATGCAGATAACCCCGAGCTAACGGATCAAGA
TTTTCTCAATGCCAAACCTGCATCTGTAGCTGTGCCAGCATTAGCAGCACAGCGTAGAGTAAGAGGGCCACAAAAAGCTC
CCACAAAGAAGCTTGTATCGATTCGTCTTGACCCCGATTTGATTGACCGGCTGAAACAGGACGGCCCTGGTTGGCAAGGG
CGCGTTAACGATATGCTACGGCAAGCCATAGGCCTAACCAGTTAG

Structures

Toxin

• AlphaFold DB: A0A346DWK5