Detailed information of TA system TA078932

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1560362..1560997
• Replicon: chromosome
• Accession: NZ_CP022374
• Organism: Acetobacter oryzifermentans strain dm

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: CBI36_RS07530
• Protein ID: WP_014106242.1
• Coordinates: 1560362..1560772 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G2I1D7
• Locus tag: CBI36_RS07535
• Protein ID: WP_010511771.1
• Coordinates: 1560773..1560997 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CBI36_RS07510	1555489..1557411	+	1923	WP_035362735.1	threonine--tRNA ligase	-
CBI36_RS07515	1557408..1559141	+	1734	WP_003626794.1	ABC transporter ATP-binding protein/permease	-
CBI36_RS07520	1559242..1559592	+	351	WP_197051011.1	metalloregulator ArsR/SmtB family transcription factor	-
CBI36_RS07525	1559589..1559759	+	171	WP_075624995.1	metallothionein	-
CBI36_RS07530	1560362..1560772	-	411	WP_014106242.1	tRNA(fMet)-specific endonuclease VapC	Toxin
CBI36_RS07535	1560773..1560997	-	225	WP_010511771.1	hypothetical protein	Antitoxin
CBI36_RS07540	1561177..1561596	+	420	WP_052051562.1	hypothetical protein	-
CBI36_RS07545	1561822..1562718	-	897	WP_014106240.1	NAD-dependent epimerase/dehydratase family protein	-
CBI36_RS07550	1562768..1563424	-	657	WP_052051561.1	alpha-ketoglutarate-dependent dioxygenase AlkB	-
CBI36_RS07555	1563618..1564727	-	1110	WP_014106238.1	NADH:flavin oxidoreductase/NADH oxidase	-
CBI36_RS07560	1564923..1565810	+	888	WP_014106237.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1535046..1560997	25951

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (9-55)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15558.79 Da
• Isoelectric Point: 6.4680

>T78932 WP_014106242.1 NZ_CP022374:c1560772-1560362 [Acetobacter oryzifermentans]
MLRYLLDTNLCIRVLRDRPQGLRPRFNSCAEELCISDVVLYELLYGAERSSDPVRTRREVERFAARLAVLPFDSEAAAHT
ADIRAELERNGRIIGPYDLMIAGHARSRGLIVVTGNLREFQRVEGLRTEDWLTDTV

Nucleotide

• Length: 411 bp

>T78932 NZ_CP022374:c1560772-1560362 [Acetobacter oryzifermentans]
ATGCTGCGTTATCTGCTGGATACGAACCTCTGTATCCGGGTATTGCGGGATCGACCACAAGGGCTGCGTCCGAGGTTCAA
CAGCTGTGCGGAGGAACTCTGCATCTCGGACGTGGTTCTGTATGAGCTGCTTTATGGCGCAGAACGCTCGTCCGATCCCG
TGCGCACAAGGCGTGAAGTCGAGCGCTTCGCGGCAAGGCTGGCGGTCCTGCCATTCGACAGTGAAGCAGCCGCCCATACG
GCAGACATTCGGGCCGAACTTGAACGGAATGGCCGTATCATAGGTCCGTATGATCTCATGATTGCCGGGCATGCCCGGAG
CAGAGGGCTGATTGTTGTGACCGGCAATCTGCGGGAATTTCAGCGGGTGGAGGGTCTTCGAACCGAGGACTGGCTGACTG
ACACGGTCTGA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8217.39 Da
• Isoelectric Point: 4.9816

>AT78932 WP_010511771.1 NZ_CP022374:c1560997-1560773 [Acetobacter oryzifermentans]
MLTRTTLFLSNRSQAVRLPKMVAFGEQVRDVVIVSEGSRRIIAPADAAWDDFFAAPGVDLGERNQPAMQEREAL

Nucleotide

• Length: 225 bp

>AT78932 NZ_CP022374:c1560997-1560773 [Acetobacter oryzifermentans]
ATGCTGACCCGTACGACACTCTTTCTATCCAACCGCTCGCAGGCAGTGCGCCTGCCGAAGATGGTCGCCTTCGGGGAGCA
GGTGCGTGACGTCGTCATTGTGTCCGAAGGTTCACGACGCATCATCGCCCCCGCTGACGCAGCGTGGGATGATTTCTTTG
CGGCTCCCGGCGTGGATCTGGGGGAGCGGAACCAGCCGGCCATGCAGGAACGTGAGGCGCTCTGA

Structures

Antitoxin

• AlphaFold DB: A0A094ZE42