Detailed information of TA system TA078931

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 900168..900751
• Replicon: chromosome
• Accession: NZ_CP022374
• Organism: Acetobacter oryzifermentans strain dm

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: F1YT37
• Locus tag: CBI36_RS04505
• Protein ID: WP_006116155.1
• Coordinates: 900168..900422 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: CBI36_RS04510
• Protein ID: WP_089178780.1
• Coordinates: 900419..900751 (+)
• Length: 111 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CBI36_RS04485	895348..895689	+	342	WP_089178778.1	hypothetical protein	-
CBI36_RS04490	896088..896429	-	342	WP_089179899.1	hypothetical protein	-
CBI36_RS04495	896789..898384	-	1596	WP_089178779.1	restriction endonuclease	-
CBI36_RS04500	898728..899928	+	1201	Protein_876	tyrosine-type recombinase/integrase	-
CBI36_RS04505	900168..900422	+	255	WP_006116155.1	type II toxin-antitoxin system HicA family toxin	Toxin
CBI36_RS04510	900419..900751	+	333	WP_089178780.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
CBI36_RS04515	901059..901397	-	339	WP_202980433.1	terminase small subunit	-
CBI36_RS04520	901470..902720	-	1251	WP_012812328.1	IS701-like element IS1452 family transposase	-
CBI36_RS04525	902815..904923	+	2109	WP_162870718.1	transglycosylase SLT domain-containing protein	-
CBI36_RS04530	904923..905186	+	264	WP_035353185.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	901470..902705	1235

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-81)

Antitoxin

• Uncharacterised protein family HicB (56-105)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9479.92 Da
• Isoelectric Point: 10.3861

>T78931 WP_006116155.1 NZ_CP022374:900168-900422 [Acetobacter oryzifermentans]
MKAKHRRTLELIFKRPVSGNVPWADIEALFVSLGAEVSEREGSRIGVFLFDEVKVFHRPHPKPDTDKGAVASVRKWLEQN
GVTP

Nucleotide

• Length: 255 bp

>T78931 NZ_CP022374:900168-900422 [Acetobacter oryzifermentans]
ATGAAAGCCAAGCACCGCCGCACATTGGAACTGATTTTCAAGCGTCCTGTTTCGGGCAATGTGCCATGGGCAGACATTGA
AGCTTTATTTGTTTCCCTAGGGGCGGAGGTGTCTGAAAGAGAAGGCTCCCGCATAGGGGTGTTCCTGTTTGATGAGGTAA
AGGTGTTTCATAGACCTCACCCCAAACCGGATACAGACAAGGGTGCTGTAGCCTCTGTAAGAAAATGGCTTGAGCAGAAT
GGAGTGACGCCATGA

Antitoxin

Protein

• Length: 111 a.a.
• Molecular weight: 12020.69 Da
• Isoelectric Point: 4.6742

>AT78931 WP_089178780.1 NZ_CP022374:900419-900751 [Acetobacter oryzifermentans]
MNNVMEIGGHRAVIQFDPEIGMFRGEFLGLNGGADFYADSVAGLQQEGETSLRVFMEMCAEKGIDPVKHYSGRFVVRLPE
DVHARVAEIAAARGISLNRLVQDVLAQVEG

Nucleotide

• Length: 333 bp

>AT78931 NZ_CP022374:900419-900751 [Acetobacter oryzifermentans]
ATGAACAACGTAATGGAAATTGGCGGCCATCGGGCTGTTATTCAGTTTGATCCTGAAATCGGGATGTTCCGGGGTGAGTT
TCTGGGGCTGAACGGAGGGGCTGATTTCTACGCAGATAGTGTGGCAGGCCTTCAGCAGGAAGGGGAAACTTCCCTCCGTG
TCTTCATGGAGATGTGTGCTGAGAAAGGCATTGATCCCGTGAAGCATTATTCAGGCCGGTTTGTTGTGAGGCTACCAGAA
GACGTTCATGCACGGGTAGCTGAGATTGCTGCAGCACGCGGGATCAGTCTTAACCGACTGGTGCAGGATGTTTTGGCACA
GGTTGAAGGATAA

Structures

Toxin

• AlphaFold DB: A0A401X5W6