Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-relE/YoeB-YefM
Location 489718..490223 Replicon chromosome
Accession NZ_CP022372
Organism Bosea sp. AS-1

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag CE453_RS03990 Protein ID WP_089173403.1
Coordinates 489969..490223 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name relE Uniprot ID -
Locus tag CE453_RS03985 Protein ID WP_089173402.1
Coordinates 489718..489972 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CE453_RS03940 484752..485141 - 390 WP_089177691.1 MbcA/ParS/Xre antitoxin family protein -
CE453_RS03945 485284..485943 + 660 WP_089177692.1 multiubiquitin domain-containing protein -
CE453_RS03950 485918..487105 + 1188 WP_089173396.1 ThiF family adenylyltransferase -
CE453_RS03955 487105..487506 + 402 WP_089173397.1 hypothetical protein -
CE453_RS03965 488080..488670 - 591 WP_089173399.1 recombinase family protein -
CE453_RS03970 488846..489058 + 213 WP_089173400.1 hypothetical protein -
CE453_RS03975 489323..489445 + 123 WP_157732892.1 DUF2958 domain-containing protein -
CE453_RS03980 489467..489613 + 147 WP_089177693.1 DUF2958 domain-containing protein -
CE453_RS03985 489718..489972 + 255 WP_089173402.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
CE453_RS03990 489969..490223 + 255 WP_089173403.1 Txe/YoeB family addiction module toxin Toxin
CE453_RS03995 490249..491004 + 756 WP_089173404.1 metallophosphoesterase -
CE453_RS04000 491080..492174 + 1095 WP_089173405.1 HAD-IA family hydrolase -
CE453_RS04005 492487..493278 + 792 WP_089173406.1 metallophosphoesterase -
CE453_RS04010 493694..493960 + 267 WP_198302256.1 WGR domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 448947..504916 55969


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9931.45 Da        Isoelectric Point: 9.6855

>T78930 WP_089173403.1 NZ_CP022372:489969-490223 [Bosea sp. AS-1]
MKLVFHEQAWEDYLHWQATDPKLLVRLNGLIKECTRTPFNGTGKPEPLRGPLSGWWSRRITQEHRLVYRPSEGGLLIAQC
RFHY

Download         Length: 255 bp

>T78930 NZ_CP022372:489969-490223 [Bosea sp. AS-1]
ATGAAACTCGTCTTCCACGAACAGGCCTGGGAGGATTACCTGCATTGGCAGGCGACCGATCCCAAGCTGCTGGTCCGGCT
CAACGGGCTCATCAAAGAATGCACGCGCACGCCATTTAACGGCACCGGCAAGCCGGAGCCGTTGCGCGGTCCGCTGTCGG
GCTGGTGGTCGCGACGGATCACACAGGAGCACCGCCTGGTCTATCGGCCAAGTGAGGGCGGTCTATTGATCGCGCAATGC
CGGTTTCACTACTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9657.03 Da        Isoelectric Point: 7.0133

>AT78930 WP_089173402.1 NZ_CP022372:489718-489972 [Bosea sp. AS-1]
MRTTSYTDLRKNLATMLDRVTEDHAPMLITRDKGKPAAVLMSLEDYASYEETRYLLRNPRNADRLLKAVKELDEGKGTER
VLAE

Download         Length: 255 bp

>AT78930 NZ_CP022372:489718-489972 [Bosea sp. AS-1]
ATGCGAACAACGTCCTACACCGACCTGCGAAAGAATCTAGCCACCATGCTCGACAGGGTGACCGAGGATCACGCGCCGAT
GCTCATCACCCGGGATAAGGGAAAGCCTGCGGCGGTGCTGATGTCGCTCGAAGATTACGCCTCTTATGAGGAAACGCGCT
ATCTCCTCCGGAATCCGCGCAATGCTGACCGGCTGCTCAAGGCCGTAAAGGAGCTCGATGAAGGCAAAGGAACCGAACGC
GTCCTTGCCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References