Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 114435..114979 Replicon plasmid pSHE-CTX-M
Accession NZ_CP022359
Organism Shewanella bicestrii strain JAB-1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag CF168_RS21640 Protein ID WP_089069034.1
Coordinates 114704..114979 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag CF168_RS21635 Protein ID WP_089069033.1
Coordinates 114435..114704 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CF168_RS21610 109480..110718 - 1239 WP_089069028.1 efflux RND transporter periplasmic adaptor subunit -
CF168_RS21615 110720..111997 - 1278 WP_089069029.1 TolC family protein -
CF168_RS21620 112045..112437 - 393 WP_089069030.1 hypothetical protein -
CF168_RS21625 112529..112879 - 351 WP_089069031.1 DUF3147 family protein -
CF168_RS21630 113177..114157 - 981 WP_089069032.1 DNA-binding protein -
CF168_RS21635 114435..114704 + 270 WP_089069033.1 ribbon-helix-helix protein, CopG family Antitoxin
CF168_RS21640 114704..114979 + 276 WP_089069034.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CF168_RS21645 114982..116169 + 1188 WP_089069035.1 hypothetical protein -
CF168_RS21650 116175..117113 + 939 WP_089069036.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaCTX-M-15 / aac(3)-IIa / blaOXA-1 / aac(6')-Ib-cr / tet(A) / blaSHV-12 / aph(6)-Id / aph(3'')-Ib / sul2 - 1..193338 193338
- flank IS/Tn - - 117217..120222 3005


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-44)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10757.47 Da        Isoelectric Point: 9.5571

>T78921 WP_089069034.1 NZ_CP022359:114704-114979 [Shewanella bicestrii]
MELKWTSKALSDIARLYEFLATDHPQAAARTVQSLTRAPTVLLINPQIGEQLFEFMPREVRRLLIGQYELRYELQGQTVY
LLRLWHTREAR

Download         Length: 276 bp

>T78921 NZ_CP022359:114704-114979 [Shewanella bicestrii]
ATGGAGTTGAAATGGACCAGTAAGGCTCTGTCAGATATCGCGCGACTCTACGAATTTCTCGCTACGGATCACCCGCAGGC
TGCGGCCCGAACGGTGCAGAGTCTGACGAGAGCGCCAACGGTTTTGTTGATCAACCCACAGATCGGTGAGCAGCTGTTCG
AGTTTATGCCGCGAGAAGTCCGCCGCTTGTTGATTGGCCAGTATGAACTACGCTATGAGCTGCAGGGGCAAACTGTCTAC
CTGTTACGATTGTGGCACACTCGAGAAGCACGATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9900.18 Da        Isoelectric Point: 5.0760

>AT78921 WP_089069033.1 NZ_CP022359:114435-114704 [Shewanella bicestrii]
MTQTATKVLTAHIPQPLAERLDQAAGRLDRSRGWIMKQALSAWLSQEEERERLTREALADVDAGQVIDHQAVLAWAESLS
SDTPLPVPR

Download         Length: 270 bp

>AT78921 NZ_CP022359:114435-114704 [Shewanella bicestrii]
ATGACACAAACGGCGACCAAAGTATTGACGGCGCACATTCCACAACCCTTGGCAGAGCGGCTTGATCAGGCCGCTGGCCG
GCTCGATCGTTCGCGTGGGTGGATCATGAAACAAGCCTTGTCGGCCTGGCTGTCGCAAGAAGAAGAACGTGAACGGCTGA
CACGGGAAGCCCTTGCCGATGTAGATGCAGGCCAGGTGATTGATCATCAGGCTGTGCTCGCCTGGGCAGAGAGTCTTAGC
AGCGACACGCCCTTGCCGGTGCCGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References