Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1962787..1964612 Replicon chromosome
Accession NZ_CP022353
Organism Vibrio sp. 2521-89

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag CEQ48_RS14700 Protein ID WP_198301167.1
Coordinates 1962787..1964148 (+) Length 454 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag CEQ48_RS14705 Protein ID WP_198301168.1
Coordinates 1964145..1964612 (+) Length 156 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEQ48_RS14660 1957838..1959502 + 1665 WP_000879550.1 DNA repair protein RecN -
CEQ48_RS14665 1959661..1960020 + 360 WP_001160907.1 outer membrane protein assembly factor BamE -
CEQ48_RS14670 1960098..1960403 - 306 WP_001929603.1 RnfH family protein -
CEQ48_RS14675 1960406..1960840 - 435 WP_089071757.1 type II toxin-antitoxin system RatA family toxin -
CEQ48_RS14680 1961024..1961509 + 486 WP_000162689.1 SsrA-binding protein SmpB -
CEQ48_RS14690 1962128..1962388 + 261 Protein_1751 DUF4102 domain-containing protein -
CEQ48_RS14700 1962787..1964148 + 1362 WP_198301167.1 type II toxin-antitoxin system HipA family toxin Toxin
CEQ48_RS14705 1964145..1964612 + 468 WP_198301168.1 helix-turn-helix domain-containing protein Antitoxin
CEQ48_RS14715 1965211..1968351 - 3141 WP_089071761.1 DEAD/DEAH box helicase -
CEQ48_RS14725 1968776..1969459 + 684 WP_089071763.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-383)

Antitoxin

Cro/C1-type helix-turn-helix domain

(80-138)


Sequences

Toxin        


Download         Length: 454 a.a.        Molecular weight: 51404.31 Da        Isoelectric Point: 4.9785

>T78918 WP_198301167.1 NZ_CP022353:1962787-1964148 [Vibrio sp. 2521-89]
MEELTVQAFIRGEWIDIGIISFPKSSQHNFRVTELNYLSDYALEHYDKDDFHAVSLNHPVSFFFDDMGKPRWLKFLDDIM
PSGASRRYWVKHLDIEDLSSDEQDYVLLKFGTMSPIGNLRIKDSLPERYEVADNLYFSVDDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLILRCSFDHGSGSEKIWIDPYQDDNSNHDLHYLVKYPRGSRSTIDCNILRAEFYFYHELTEMGVETIS
TDGMRLEEGLNYPSLWLPRFDVQIIDQQIERFGMESVYSILNKGAGVTLDHETTIRTLIEKITESNMVKHQGYRFDTQAF
VIEWVKRDLLNILFGNSDNHGRNTSFLKGDGVIKLAPIYDFAPMKADPAGIPRTTKWKAPLEVGGTYDFVGIADTLSDLV
PKEVLLKELAITASKCVGLKQRLALRGVPEQILEMPAVGLNYLSEKLTKWGLL

Download         Length: 1362 bp

>T78918 NZ_CP022353:1962787-1964148 [Vibrio sp. 2521-89]
ATGGAAGAGCTAACCGTACAAGCTTTTATCAGAGGTGAATGGATAGATATTGGTATCATCTCATTCCCTAAAAGTAGCCA
ACATAATTTCCGAGTGACTGAACTCAACTACCTCAGCGACTATGCGCTAGAACATTACGATAAAGATGACTTTCACGCTG
TTTCACTAAACCACCCTGTCTCATTCTTTTTTGATGACATGGGTAAGCCTAGATGGTTAAAGTTTCTAGACGATATTATG
CCTAGTGGCGCTAGTAGACGATACTGGGTCAAACACCTAGATATTGAAGATCTTAGTTCTGATGAACAAGACTATGTTTT
GCTCAAGTTTGGCACGATGTCGCCTATTGGTAACTTAAGAATAAAAGACTCCCTTCCTGAACGCTACGAAGTCGCAGACA
ACCTCTACTTCTCTGTTGATGATGTTAAAAATCGAGCTGGTGATTTCCTCGACTACGCACAACAAAGAGGGGCAGCCGCA
GGTGGTGCAACTGGGGCTGGAGGTGAAGCGCCAAAACTGATCCTCCGATGTAGTTTCGATCATGGATCTGGCAGCGAAAA
AATATGGATTGATCCATACCAAGATGACAATAGCAACCACGACTTACATTACTTAGTAAAGTACCCTAGAGGCTCAAGAA
GCACCATCGACTGTAATATTCTAAGAGCTGAGTTCTACTTCTACCACGAGCTAACTGAAATGGGAGTTGAAACGATCTCC
ACCGACGGTATGCGCTTGGAGGAAGGATTAAACTACCCTTCCTTATGGCTTCCTCGATTTGATGTTCAAATTATTGATCA
ACAAATAGAGAGATTTGGCATGGAATCTGTGTATTCCATTTTGAACAAAGGCGCTGGGGTCACTCTTGATCACGAAACAA
CAATCCGAACTCTCATAGAAAAAATTACTGAAAGTAATATGGTTAAACACCAAGGGTATAGGTTCGATACCCAAGCTTTC
GTTATTGAATGGGTGAAGAGAGATCTACTCAACATCTTGTTTGGTAATAGTGATAACCATGGCAGAAATACTTCATTCTT
AAAGGGTGATGGAGTCATAAAGCTTGCTCCCATTTACGATTTCGCACCAATGAAAGCCGATCCTGCAGGAATTCCAAGAA
CAACAAAATGGAAAGCCCCACTAGAGGTTGGTGGAACTTACGACTTTGTCGGCATTGCAGACACCTTATCTGATCTGGTG
CCAAAGGAAGTGTTATTAAAAGAGCTAGCAATTACTGCAAGTAAATGCGTAGGCCTAAAGCAGAGACTCGCTTTACGAGG
AGTACCAGAACAAATCTTGGAGATGCCAGCCGTTGGACTTAATTATTTATCAGAAAAGCTCACTAAATGGGGGCTACTAT
GA

Antitoxin


Download         Length: 156 a.a.        Molecular weight: 17115.64 Da        Isoelectric Point: 10.7497

>AT78918 WP_198301168.1 NZ_CP022353:1964145-1964612 [Vibrio sp. 2521-89]
MKPSNKESVQDTIARLRANRNQQQPKVGKNATHSIKEQTPLDTPTRSKASKNAKAVSAAERKTEANKIIRHLLLGELTQG
QALKSLRINILGLKQDVFARLVDVSRKTLSDIENDRGSYNTEILNKVFKPFSLKIGLLPSSPDALKSLLMDGEDG

Download         Length: 468 bp

>AT78918 NZ_CP022353:1964145-1964612 [Vibrio sp. 2521-89]
ATGAAGCCAAGCAATAAAGAGTCCGTACAAGATACGATAGCTCGTCTAAGAGCAAACCGAAATCAACAGCAGCCCAAGGT
TGGGAAGAATGCAACTCATTCGATCAAAGAGCAAACACCACTCGATACTCCAACGAGATCGAAAGCCTCAAAAAACGCCA
AAGCAGTAAGTGCAGCAGAGCGCAAAACCGAGGCAAACAAAATCATCAGACACTTGTTGCTTGGAGAGCTAACACAGGGC
CAAGCGCTGAAAAGTCTACGCATTAATATACTGGGACTCAAACAGGATGTATTCGCAAGACTTGTCGATGTCTCAAGAAA
AACACTCTCAGACATAGAGAATGATCGGGGCAGCTACAATACAGAGATTCTCAACAAGGTATTCAAACCATTTAGCTTAA
AAATCGGGCTACTGCCTTCTTCTCCCGATGCGTTAAAATCGCTCTTAATGGATGGTGAGGATGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References