Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/-
Location 133114..133898 Replicon chromosome
Accession NZ_CP022352
Organism Vibrio sp. 2521-89

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag CEQ48_RS01045 Protein ID WP_001114075.1
Coordinates 133629..133898 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID Q9KM84
Locus tag CEQ48_RS01040 Protein ID WP_000921691.1
Coordinates 133114..133635 (-) Length 174 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEQ48_RS00990 128799..129035 + 237 WP_000772125.1 RNA-binding protein -
CEQ48_RS01000 129210..129674 - 465 WP_089069904.1 GNAT family N-acetyltransferase -
CEQ48_RS01010 129814..130554 - 741 WP_089069905.1 NYN domain-containing protein -
CEQ48_RS01015 130709..131890 - 1182 WP_089069906.1 helix-hairpin-helix domain-containing protein -
CEQ48_RS01025 132146..132338 - 193 Protein_163 DUF645 family protein -
CEQ48_RS01040 133114..133635 - 522 WP_000921691.1 DUF2442 domain-containing protein Antitoxin
CEQ48_RS01045 133629..133898 - 270 WP_001114075.1 DUF4160 domain-containing protein Toxin
CEQ48_RS01055 134098..135300 - 1203 WP_198301105.1 DUF3644 domain-containing protein -
CEQ48_RS01065 135446..135934 - 489 WP_089069910.1 GNAT family N-acetyltransferase -
CEQ48_RS01075 136125..136370 + 246 WP_043990290.1 type II toxin-antitoxin system CcdA family antitoxin -
CEQ48_RS01080 136370..136687 + 318 WP_089069911.1 CcdB family protein -
CEQ48_RS01085 136804..137340 - 537 WP_089069912.1 nucleotidyltransferase family protein -
CEQ48_RS01090 137489..137908 - 420 WP_089069913.1 ClbS/DfsB family four-helix bundle protein -
CEQ48_RS01095 137969..138820 - 852 WP_089069862.1 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 78239..171673 93434
- inside Integron - - 85142..168415 83273


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Protein of unknown function DUF2442

(4-59)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T78916 WP_001114075.1 NZ_CP022352:c133898-133629 [Vibrio sp. 2521-89]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T78916 NZ_CP022352:c133898-133629 [Vibrio sp. 2521-89]
ATGCCAGAGATTGATGCCCTATTAGGCCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTGCCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 174 a.a.        Molecular weight: 19409.01 Da        Isoelectric Point: 6.7342

>AT78916 WP_000921691.1 NZ_CP022352:c133635-133114 [Vibrio sp. 2521-89]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Download         Length: 522 bp

>AT78916 NZ_CP022352:c133635-133114 [Vibrio sp. 2521-89]
ATGTTGAAAGTCATAGATGTTGATTTTGTCTCAGACCATACATTAGAACTGACGTTCAATGATGGTTACCAAGGCTATGC
CGACTTGTCGGTATACTTTAAAAAAGCACCGTTTTCAGAAATTAAGGACTTTAAACGCTTTTCCTTGACTCGTGATGGCT
CATTAAATTGGGATGGTAATGAGTTAACGGCCGCGACACTCCGTGACATAACCAAGGGCTCACAAAAGTCGGTGGAGTTA
AGTTTTAATGTTCAAGAAATGGAAGCCGTCATCAAACAGGCCTCATGGGAATCGATGATGGAGGGGCGTCCCGACATCTT
GCAAGCGGCTATTCGTTCTTACGTAGAGCAGTTTGGTCATGGTCAAGTTATTGCAAAGGCGGGTATAAAAAGTCGTACGA
GTGCTTATCGCTCCTTGAAGCCAGAAACAACGCCAAACTTTGGCACACTAGTTCAGTTAGGGCACGCCGTCATCGAACTA
GCGAAAGATAGAACAGTGGCAAACAAGGAACCGCGCATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086SLD6

Antitoxin

Source ID Structure
AlphaFold DB Q9KM84

References