Detailed information of TA system TA078914

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 92524..93062
• Replicon: chromosome
• Accession: NZ_CP022352
• Organism: Vibrio sp. 2521-89

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: CEQ48_RS00555
• Protein ID: WP_000802134.1
• Coordinates: 92763..93062 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: CEQ48_RS00550
• Protein ID: WP_089069870.1
• Coordinates: 92524..92766 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CEQ48_RS00490	87526..88389	-	864	WP_000030909.1	hypothetical protein	-
CEQ48_RS00495	88588..88767	-	180	WP_089069867.1	DUF645 family protein	-
CEQ48_RS00510	89606..89740	-	135	WP_161803507.1	DUF645 family protein	-
CEQ48_RS00525	90141..90323	-	183	WP_198301103.1	DUF645 family protein	-
CEQ48_RS00530	90641..91006	-	366	WP_061051366.1	hypothetical protein	-
CEQ48_RS00540	91186..91575	-	390	WP_055032899.1	VOC family protein	-
CEQ48_RS00545	91780..92361	-	582	WP_198301104.1	nucleotidyltransferase family protein	-
CEQ48_RS00550	92524..92766	+	243	WP_089069870.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
CEQ48_RS00555	92763..93062	+	300	WP_000802134.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CEQ48_RS00560	93180..93620	-	441	WP_089069871.1	GNAT family N-acetyltransferase	-
CEQ48_RS00565	93761..94099	-	339	Protein_100	hypothetical protein	-
CEQ48_RS00575	94297..94476	-	180	WP_071193265.1	DUF645 family protein	-
CEQ48_RS20010	94554..94715	-	162	Protein_102	acetyltransferase	-
CEQ48_RS00585	94772..94882	-	111	Protein_103	GNAT family N-acetyltransferase	-
CEQ48_RS00590	94916..95767	-	852	WP_089069862.1	IS3 family transposase	-
CEQ48_RS00595	95851..96072	-	222	Protein_105	transposase	-
CEQ48_RS00600	96263..96649	-	387	WP_001015086.1	MmcQ/YjbR family DNA-binding protein	-
CEQ48_RS19790	96848..96904	-	57	WP_157724687.1	DUF645 family protein	-
CEQ48_RS00605	96905..97030	-	126	WP_089069872.1	DUF645 family protein	-
CEQ48_RS00620	97324..97812	-	489	WP_000110029.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	78239..171673	93434
	-	inside	Integron	-	-	85142..168415	83273

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-92)

Antitoxin

• Antitoxin ParD (4-71)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11601.34 Da
• Isoelectric Point: 9.9232

>T78914 WP_000802134.1 NZ_CP022352:92763-93062 [Vibrio sp. 2521-89]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQIGSQQ
IRVIRILHKSMDVNPIFGA

Nucleotide

• Length: 300 bp

>T78914 NZ_CP022352:92763-93062 [Vibrio sp. 2521-89]
ATGAAACCATTTAATCTTACTGTCGCCGCTAAAGCCGATTTACGGGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATCGGTAAATCAT
GCGATGAAATTCGAGAGGGATACAGAAAATTTCCCCAAGGGAGCCACGTCATCTTTTATCAGCAAATCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTTGGCGCATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8992.90 Da
• Isoelectric Point: 4.1677

>AT78914 WP_089069870.1 NZ_CP022352:92524-92766 [Vibrio sp. 2521-89]
MAKNTSITLGEHFDVFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLVEGEQSGDADYDLDSFINELDSENIR

Nucleotide

• Length: 243 bp

>AT78914 NZ_CP022352:92524-92766 [Vibrio sp. 2521-89]
ATGGCTAAAAACACAAGTATCACTCTTGGTGAACACTTCGATGTCTTTATTACAAGCCAAATACAAAGTGGACGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAGAACCAAGAAACCAAACTACAGTCACTCCGTCAATTAC
TCGTTGAAGGTGAGCAAAGTGGTGATGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA