Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 72313..72848 Replicon plasmid pK516_KPC
Accession NZ_CP022349
Organism Klebsiella michiganensis strain K516

Toxin (Protein)


Gene name relE Uniprot ID A0A6M4NRI2
Locus tag CF000_RS30500 Protein ID WP_032693963.1
Coordinates 72313..72600 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag CF000_RS30505 Protein ID WP_032693964.1
Coordinates 72597..72848 (-) Length 84 a.a.

Genomic Context

CF000_RS30470CF000_RS30475CF000_RS30480CF000_RS30485CF000_RS30520CF000_RS30525CF000_RS30530CF000_RS30535CF000_RS30540CF000_RS30490CF000_RS30495CF000_RS30500CF000_RS30505CF000_RS30510CF000_RS30515
Location: 67903..68535 (633 bp)
Type: Others
Protein ID: WP_080884176.1
Location: 68535..68909 (375 bp)
Type: Others
Protein ID: WP_088903436.1
Location: 69149..70123 (975 bp)
Type: Others
Protein ID: WP_080884175.1
Location: 70127..70519 (393 bp)
Type: Others
Protein ID: WP_080884174.1
Location: 74924..75154 (231 bp)
Type: Others
Protein ID: WP_032693967.1
Location: 75589..75822 (234 bp)
Type: Others
Protein ID: WP_080884170.1
Location: 75819..76154 (336 bp)
Type: Others
Protein ID: WP_080884169.1
Location: 76538..77239 (702 bp)
Type: Others
Protein ID: WP_080884168.1
Location: 77239..77460 (222 bp)
Type: Others
Protein ID: WP_053390281.1
Location: 70795..71295 (501 bp)
Type: Others
Protein ID: WP_080884173.1
Location: 72042..72230 (189 bp)
Type: Others
Protein ID: WP_080884172.1
Location: 72313..72600 (288 bp)
Type: Toxin
Protein ID: WP_032693963.1
Location: 72597..72848 (252 bp)
Type: Antitoxin
Protein ID: WP_032693964.1
Location: 73015..74289 (1275 bp)
Type: Others
Protein ID: WP_080884171.1
Location: 74289..74714 (426 bp)
Type: Others
Protein ID: WP_032693966.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CF000_RS3047067903..68535+633WP_080884176.1ParA family protein-
CF000_RS3047568535..68909+375WP_088903436.1hypothetical protein-
CF000_RS3048069149..70123+975WP_080884175.1StbA family protein-
CF000_RS3048570127..70519+393WP_080884174.1plasmid partitioning/stability family protein-
CF000_RS3049070795..71295-501WP_080884173.1hypothetical protein-
CF000_RS3049572042..72230-189WP_080884172.1hypothetical protein-
CF000_RS3050072313..72600-288WP_032693963.1type II toxin-antitoxin system RelE/ParE family toxinToxin
CF000_RS3050572597..72848-252WP_032693964.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
CF000_RS3051073015..74289-1275WP_080884171.1Y-family DNA polymerase-
CF000_RS3051574289..74714-426WP_032693966.1translesion error-prone DNA polymerase V autoproteolytic subunit-
CF000_RS3052074924..75154+231WP_032693967.1hypothetical protein-
CF000_RS3052575589..75822+234WP_080884170.1hypothetical protein-
CF000_RS3053075819..76154+336WP_080884169.1hypothetical protein-
CF000_RS3053576538..77239+702WP_080884168.1DNA methylase-
CF000_RS3054077239..77460+222WP_053390281.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideConjugative plasmidblaKPC-2-1..126877126877


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11133.12 Da        Isoelectric Point: 10.2246

>T78911 WP_032693963.1 NZ_CP022349:c72600-72313 [Klebsiella michiganensis]
MTYTVKFREDALKEWQKLDKAIQQQFAKKLKKCCDEPHIPSAKLRGIKDCYKIKLRASGFRLVYQVIDDQLIIAVVAVGK
RERSDVYNLASERMR

Download         Length: 288 bp

>T78911 NZ_CP022349:c72600-72313 [Klebsiella michiganensis]
ATGACTTATACGGTCAAATTCAGGGAAGATGCGCTGAAGGAATGGCAAAAGCTGGATAAGGCCATTCAGCAACAGTTTGC
GAAGAAGCTGAAGAAGTGCTGTGACGAACCACATATCCCCTCAGCAAAGCTGAGAGGGATAAAGGACTGCTATAAAATTA
AACTTCGCGCGTCAGGCTTTCGTCTGGTCTATCAGGTAATAGATGATCAACTGATTATTGCTGTTGTGGCTGTCGGAAAG
CGTGAACGTAGTGACGTGTACAATCTGGCCAGCGAACGGATGAGGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9202.49 Da        Isoelectric Point: 4.0785

>AT78911 WP_032693964.1 NZ_CP022349:c72848-72597 [Klebsiella michiganensis]
MPNIILSDTSASISELKKNPMATVSAGDGFPVAILNRNQPAFYCIPAELYEKMLDALDDQELAKLVSERSNQRLLDVDLD
TYL

Download         Length: 252 bp

>AT78911 NZ_CP022349:c72848-72597 [Klebsiella michiganensis]
ATGCCCAACATTATTCTGAGTGACACAAGCGCGAGCATCAGCGAACTTAAAAAAAACCCGATGGCGACGGTCAGTGCCGG
CGACGGCTTCCCGGTCGCTATTCTGAACCGTAATCAGCCCGCTTTTTACTGCATCCCGGCAGAGCTTTACGAGAAGATGC
TCGATGCCCTGGATGATCAGGAACTGGCAAAGCTGGTTTCAGAACGCAGTAACCAGCGACTGCTTGACGTGGATCTGGAC
ACATATCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A6M4NRI2

Antitoxin

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Source
ID
Structure
No matching records found

References