Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4986666..4987285 Replicon chromosome
Accession NZ_CP022348
Organism Klebsiella michiganensis strain K516

Toxin (Protein)


Gene name Hha Uniprot ID H3N9D8
Locus tag CF000_RS24255 Protein ID WP_004099646.1
Coordinates 4986666..4986884 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID H3N7X7
Locus tag CF000_RS24260 Protein ID WP_004129911.1
Coordinates 4986911..4987285 (-) Length 125 a.a.

Genomic Context

CF000_RS24225CF000_RS24230CF000_RS24240CF000_RS24235CF000_RS24245CF000_RS24250CF000_RS24255CF000_RS24260CF000_RS24265CF000_RS24270
Location: 4982711..4982974 (264 bp)
Type: Others
Protein ID: WP_004848323.1
Location: 4982974..4983114 (141 bp)
Type: Others
Protein ID: WP_003859006.1
Location: 4983911..4985365 (1455 bp)
Type: Others
Protein ID: WP_014837606.1
Location: 4983111..4983809 (699 bp)
Type: Others
Protein ID: WP_014228203.1
Location: 4985340..4985810 (471 bp)
Type: Others
Protein ID: WP_014228205.1
Location: 4985937..4986503 (567 bp)
Type: Others
Protein ID: WP_014837607.1
Location: 4986666..4986884 (219 bp)
Type: Toxin
Protein ID: WP_004099646.1
Location: 4986911..4987285 (375 bp)
Type: Antitoxin
Protein ID: WP_004129911.1
Location: 4987765..4990911 (3147 bp)
Type: Others
Protein ID: WP_014228207.1
Location: 4990934..4992127 (1194 bp)
Type: Others
Protein ID: WP_004136054.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CF000_RS242254982711..4982974+264WP_004848323.1type B 50S ribosomal protein L31-
CF000_RS242304982974..4983114+141WP_003859006.1type B 50S ribosomal protein L36-
CF000_RS242354983111..4983809-699WP_014228203.1GNAT family N-acetyltransferase-
CF000_RS242404983911..4985365+1455WP_014837606.1PLP-dependent aminotransferase family protein-
CF000_RS242454985340..4985810-471WP_014228205.1YlaC family protein-
CF000_RS242504985937..4986503-567WP_014837607.1maltose O-acetyltransferase-
CF000_RS242554986666..4986884-219WP_004099646.1hemolysin expression modulator HhaToxin
CF000_RS242604986911..4987285-375WP_004129911.1Hha toxicity modulator TomBAntitoxin
CF000_RS242654987765..4990911-3147WP_014228207.1multidrug efflux RND transporter permease subunit-
CF000_RS242704990934..4992127-1194WP_004136054.1multidrug efflux RND transporter periplasmic adaptor subunit AcrA-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8640.05 Da        Isoelectric Point: 8.9008

>T78910 WP_004099646.1 NZ_CP022348:c4986884-4986666 [Klebsiella michiganensis]
MSDKTLTKIDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPPSVWKFIR

Download         Length: 219 bp

>T78910 NZ_CP022348:c4986884-4986666 [Klebsiella michiganensis]
ATGTCTGATAAAACATTAACCAAAATAGACTATTTGATGCGTTTACGACGCTGTCAGACAATTGATACGCTGGAGCGCGT
AATTGAAAAAAATAAATATGAACTTTCCGATAATGAACTGGCGGTATTTTACTCTGCGGCCGATCATCGTCTTGCAGAGC
TGACGATGAATAAACTGTATGACAAGATCCCCCCTTCAGTCTGGAAATTTATCCGCTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14350.09 Da        Isoelectric Point: 4.8989

>AT78910 WP_004129911.1 NZ_CP022348:c4987285-4986911 [Klebsiella michiganensis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIAAFALNYKIKYAEDNKLITQIDEYL
DDTFVLFSNYGINSADLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT78910 NZ_CP022348:c4987285-4986911 [Klebsiella michiganensis]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCGCAGCTTAAATTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTGGAAGAGAGCAACCACGGCTGGGTTAATGATCCAACCTCGGCTGTCAATCTTCAACTTAATGAATTGATCGAGC
ACATTGCCGCGTTTGCACTTAATTATAAAATTAAGTACGCAGAGGATAATAAGCTGATTACCCAGATTGACGAATATCTG
GATGACACTTTCGTCTTGTTCAGCAACTACGGCATTAACAGCGCAGATCTGCAGAAATGGCGTAAATCTGGCAATCGGTT
ATTCCGCTGCTTTGTCAACGCCAGTCGGGAAAACCCGGCCAGTCTTTCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0H3H713

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0H3HD25

References